Synovitis clinical trials
The registry lists 53 studies for Synovitis across more than 10 countries. 12 are recruiting or about to start. 9 of them are mainly about Synovitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-14. Counting its 3 narrower conditions too, such as Jacobs syndrome: 108 studies, 21 open.
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Who runs them
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (5) · Assiut University (2) · University of Alexandria (2) · Laboratorios Silanes S.A. de C.V. (1) · The Cleveland Clinic (1) · Professor of Rheumatology, MD, DMSci, Kim Horslev-Petersen (1) · Zhujiang Hospital (1) · Swedish Orphan Biovitrum (1)
What is being tested here
Drugs under test in Synovitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Methotrexate | 1 | 0 | 4 |
| Emactuzumab | 0 | 1 | 1 |
| Efanesoctocog alfa | 0 | 0 | 1 |
| Secukinumab | 0 | 1 | 1 |
| Lutikizumab | 0 | 0 | 1 |
| Etanercept | 0 | 0 | 1 |
| Fludarabine | 0 | 0 | 1 |
| Fluorodeoxyglucose F18 | 0 | 0 | 1 |
Drug classes tested here Antimetabolites 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Nov 2026A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis · Swedish Orphan Biovitrum
- Feb 2027Prevalence of Synovitis in Patients With Haemophilia A · University Hospital, Bonn
- Jul 2027Musculoskeletal Ultrasound for Differentiating Rheumatoid and Gouty Arthritis · Assiut University
- Sep 2027Musculoskeletal Ultrasound in Patients With Hematologic Malignancies · Assiut University
Who these studies take
Of the 7 Synovitis studies recruiting now, 4 (57%) set no upper age limit and 1 (14%) stop at 75 or younger. 1 (14%) take children under 18. 0 (0%) are for women only and 1 (14%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (14%) | 1 (14%) |
| 18 | 3 (43%) | 4 (57%) |
| 30 | 4 (57%) | 5 (71%) |
| 40 | 6 (86%) | 7 (100%) |
| 50 | 6 (86%) | 7 (100%) |
| 65 | 6 (86%) | 7 (100%) |
| 75 | 5 (71%) | 6 (86%) |
| 85 | 3 (43%) | 4 (57%) |
Across all 53 studies, recruiting or not: 19% stop at 75 or younger and 9% at 65; 25% take children; 2% are for women only and 4% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 53. Browse all 53 → or search them.
- Transarterial Embolization Versus Sham Procedure in Adults With Treatment-Resistant Inflammatory Arthritis of a Single Large JointNot yet recruitingNCT07873892Not applicable
- Musculoskeletal Ultrasound in Patients With Hematologic MalignanciesNot yet recruitingNCT07785505
- Musculoskeletal Ultrasound for Differentiating Rheumatoid and Gouty ArthritisNot yet recruitingNCT07657156
- Rheumatoid Arthritis Remission Screening and Prospective SurveillanceRecruitingNCT075719931 country
- Light Therapy on Pain and SynovitisRecruitingNCT07057063Not applicable2 countries
- Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OARecruitingNCT07161336Phase 21 country
- Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and KneeRecruitingNCT057006821 country
- Cellular and Molecular Analysis of Synovial Tissue of Patients With ArthritisNot yet recruitingNCT06737952
- A Real-World Study of Biologic Therapy for Subclinical Psoriatic ArthritisEnrolling by invitationNCT066860821 country
- Efficacy Of Upadacitinib In Psoriatic Arthritis And Comparison To Rheumatoid Arthritis.RecruitingNCT066307151 country
- Prevalence of Synovitis in Patients With Haemophilia ARecruitingNCT063522161 country
- Embolization in Hereditary CoagulopathiesRecruitingNCT05629130Not applicable1 country
- Corticosteroid Meniscectomy Randomized TrialActive, not recruitingNCT04641351Phase 41 country
- Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)Active, not recruitingNCT05417789Phase 312 countries
- A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa ProphylaxisActive, not recruitingNCT06752850Phase 44 countries
- Efficacy and Safety of Etoricoxib/Betamethasone Combination in Acute Bursitis, Tendinitis and SynovitisCompletedNCT07328022Phase 31 country
- Intensive Replacement Treatment in Haemophilia Patients With SynovitisCompletedNCT04784988Phase 41 country
- Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitisCompletedNCT03815448Not applicable1 country
- Pragmatic Study Comparing the Clinical Evlauation Methods ( C) and / or Ultrasound Method ( B or D) in Rheumatoid Arthritis to Adapt TreatmentCompletedNCT02410304Not applicable1 country
- Corticosteroid Therapy for Persistent Synovitis in Acute Septic Arthritis on Native JointStatus unknownNCT055312271 country
- Longitudinal ULtrasonographic Study of Patients With Spondylarthritis Starting Biological TherapyCompletedNCT012192571 country
- Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA)CompletedNCT02662985Phase 317 countries
- Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic SynovitisTerminatedNCT02060305Phase 11 country
- Comparison of the Frequency of Subclinic Synovitis in the Distal Interphalangeal Joints of the Hand in Psoriasis PatientsCompletedNCT047509931 country
- Hand OA AND Methotrexate UseTerminatedNCT01927484Not applicable1 country
- Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity PatientsCompletedNCT03022513Not applicable1 country
- Elbow Arthroscopy Data AnalysisStatus unknownNCT036561851 country
- A Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee OsteoarthritisCompletedNCT02087904Phase 2
- Synovitis and Therapy Response in Inflammatory Arthritis With Contrast Enhanced UltrasoundCompletedNCT02902562Not applicable1 country
- A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorTerminatedNCT02673736Phase 11 country
- Role of Ultrasound for Evaluating Rheumatoid Arthritis in RemissionCompletedNCT02618954Not applicable1 country
- Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in ChildrenStatus unknownNCT035079331 country
- Prospective Analgesic Compound Efficacy (PACE) StudyCompletedNCT02403687
- Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint ReplacementsCompletedNCT01272830Phase 21 country
- An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid ArthritisCompletedNCT01656278Not applicable1 country
- A Case Control Study to Define Clinical, Immunologic and Radiographic Features of the Aromatase Inhibitor Arthralgia SyndromeCompletedNCT008900581 country
- Rheumatoid Arthritis Patients on Adalimumab to Evaluate Its Effect on Synovitis Using Ultrasonography in an Egyptian PopulationTerminatedNCT01782469
- The Use of PET/CT to Evaluate Synovitis in the Temporomandibular Joint (TMJ)WithdrawnNCT01471418Phase 21 country
- A Clinical Study of Subclinical Enthesitis and Synovitis in Patients With Vulgaris PsoriasisStatus unknownNCT023396361 country
- Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid ArthritisStatus unknownNCT01731262
- Joint Ultrasound Evaluation of Asymptomatic Rheumatic FeetCompletedNCT016774161 country
- Methotrexate in Symptomatic Knee OsteoarthritisCompletedNCT01654575Not applicable1 country
- Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the KneeCompletedNCT00604539Phase 31 country
- The Relation Between Dedicated Extremity MRI Synovitis and Structural Deterioration Radiographic in Patients With Rheumatoid Arthritis in Clinical Remission. Preliminary StudyStatus unknownNCT01050010Not applicable1 country
- Study to Evaluate the Use of Ultrasound in the Diagnosis of Hemophilic Joint DiseaseCompletedNCT00212485Not applicable1 country
- Targeting Synovitis in Early Rheumatoid ArthritisStatus unknownNCT00920478Phase 41 country
- Computer-Assisted Quantification of the Synovial Perfusion in Patients With Arthritis Using Two-Dimensional and Three-Dimensional Power Doppler UltrasonographyStatus unknownNCT009039031 country
- Evaluation of The Efficacy And Safety of Intra-Articular Etanercept in Patients With Refractory Knee Joint SynovitisCompletedNCT00678782Phase 21 country
- Genetic and Immune Studies of Rheumatoid Arthritis and Related ConditionsCompletedNCT000012911 country
- Methotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and EfficacyCompletedNCT00001677Phase 21 country