An observational study in Arthritis, Rheumatoid, Neovascularization, Pathologic and Synovitis, sponsored by Third Affiliated Hospital, Sun Yat-Sen University. Status unknown. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-11-21.
Sponsored by Third Affiliated Hospital, Sun Yat-Sen University · Observational
Rheumatoid arthritis(RA) with a high incidence and high morbidity, the pathogenesis has not been fully elucidated. Fibroblast-like synovial cells excessive proliferation and synovial angiogenesis is the most important cause of RA synovitis and joint destruction. Our study was to find the role of Sonic Hedgehog(SHH) pathway in regulating proliferation of fibroblast-like synovial cells and modulating excess angiogenesis of synovial tissue.
4ml blood from active RA patients(n=35) and healthy volunteers (n=35) will be collected
Synovial tissues from 4 RA patients and 4 patients with traumatic or meniscal injury who need to carry out knee joint replacement operation will be collected
3,332 studies on the registry are indexed under Arthritis, Rheumatoid; 443 are open to participants now.
This study's planned enrollment of 78 is below the median of 176 across 1,016 observational studies indexed under Arthritis, Rheumatoid.
Browse Arthritis, Rheumatoid studies →Third Affiliated Hospital, Sun Yat-Sen University is the lead sponsor of 133 studies on the registry; 35 are open to participants now.
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residents of south China
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Exclusion Criteria:
expression of Shh pathway associated factors from peripheral blood mononuclear cells or synovial tissues will be detected
expression of Shh pathway associated factors from peripheral blood mononuclear cells or synovial tissues will be detected
mRNA expression
Time frame: 1 day (December 15, 2012)
No study locations are listed for this record.
The record gives a start of Nov 2012, a primary completion of Dec 2012 and a completion of Jan 2013. It does not say whether these dates are actual or estimated.
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This study is status unknown, as verified in Nov 2012. You cannot join it, but the record below documents what was studied.
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Third Affiliated Hospital, Sun Yat-Sen University →