An interventional study of MRI in Rheumatoid Arthritis, sponsored by Centre Hospitalier Universitaire de Nice. Status unknown at 2 sites in France. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2011-12-09.
Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Screening
The major aim of treatment for rheumatoid arthritis is remission. Nevertheless, structural radiographic progression is observed in 15 to 20% of patient getting remission. Numerous definitions of the remission proposed by literature remain imperfect.
Recently ultrasonography and MRI seem to be helpful in diagnosis and follow-up of rheumatoid arthritis.
Studies in patients with clinical remission are reporting 75 to 90% of persistent MRI and ultrasonography synovitis, 45% of cases with synovial activity.
To our knowledge, in such case few studies showed correlation between persistent imaging synovitis and structural radiographic progression.
On the other hand, no studies with extremity dedicated RMI in patients with remission are reported.
In this preliminary study, the investigators propose to evaluate in patients with rheumatoid arthritis remission and persistent dedicated MRI synovitis the structural radiographic progression at one year.
Exclusion Criteria:
Structural deterioration radiographic assessed by dedicated extremity MRI
Other: MRI
dedicated extremity MRI
Dedicated extremity MRI (hand and wrist)/ X-Ray (hand, wrist and foot)
Time frame: at Month 0 (first visit) and Month 12 (last visit)
Ultrasonography (hand, wrist and foot)
Time frame: at Month 0 (first vist) and Month 12 (last visit)
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Centre Hospitalier Universitaire de Nice