ClinicalTrials.gg
Status unknownNCT05531227SYNOVITISUpdated May 11, 2023

Corticosteroid Therapy for Persistent Synovitis in Acute Septic Arthritis on Native Joint

An observational study in Arthritis, Septic, sponsored by University Hospital, Strasbourg, France. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-05-11.

Sponsored by University Hospital, Strasbourg, France · Observational

The sponsor has not verified this record recently (last verified Jun 2022), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
100
Ages
18 Years and older
Sex
All
01

Study summary

Acute septic arthritis is a rare but life-threatening and functionally serious disease. The improvement or disappearance of pain and functional recovery are sometimes difficult to obtain, with in some cases the persistence of synovitis due to a prolonged local inflammatory response, despite early and effective treatment. The consequences are significant for patients with often significant chronic pain, repercussions on autonomy and/or profession. An unfavorable evolution with joint destruction and need for replacement by a prosthesis is not uncommon.

Corticosteroid therapy is widely used in rheumatology in similar tables, for the purpose of drug synovectomy, with good results. The risk of infection remains the main contraindication to its use.

There are very few studies on its use in septic arthritis, either fundamentally or in humans, for which there are no data in adults. However, these have shown results encouraging the investigators not to neglect this therapy.

02

Conditions studied

  • Arthritis, Septic

Keywords

  • Arthritis, Septic
  • synovitis
  • Corticosteroid therapy
  • Inflammatory response
  • Native joint
03

In context

Arthritis, Infectious

51 studies on the registry are indexed under Arthritis, Infectious; 12 are open to participants now.

This study's planned enrollment of 100 is close to the median of 100 across 30 observational studies indexed under Arthritis, Infectious.

Browse Arthritis, Infectious studies →

Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 999 studies on the registry; 358 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Adult patient (≥18 years old) having presented with septic arthritis and treated at the Strasbourg University Hospital between January 1, 2012 and December 31, 2021

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult patient (≥18 years old)
  • having presented with septic arthritis and treated at the Strasbourg University Hospital between January 1, 2012 and December 31, 2021
  • clinical finding of persistent synovitis, defined by the presence of pain, effusion or joint stiffness despite well-conducted treatment
  • having had a diagnosis of joint infection proven by a positive culture of the joint fluid to a pathogenic germ
  • having had treatment with local or systemic .

Exclusion criteria

Exclusion criteria:

  • Patient who has expressed his opposition to the reuse of his data for scientific research purposes.
  • Absence of treatment
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
100 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Complete regression of the pain in a fast way

    Time frame: 6 months after treatment with corticosteroids

07

Study locations

1 of 1 sites recruiting
  • Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France
    Strasbourg, 67091, France
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 11, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05531227
Responsible party
Sponsor
First posted
Sep 7, 2022
Start date
Jun 20, 2022
Primary completion
Dec 13, 2023 (estimated)
Completion
Dec 13, 2023 (estimated)
Last update
May 11, 2023

Study contacts

Jeannot GAUDIAS, MD
Contact
jeannot.gaudias@chru-strasbourg.fr
33 3 68 76 50 64
Saïd CHAYER, PhD, HDR
Contact
said.chayer@chru-strasbourg.fr
Jeannot GAUDIAS, MD
principal investigator · Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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