Giant Cell Tumor of Tendon Sheath clinical trials
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The registry lists 22 studies for Giant Cell Tumor of Tendon Sheath across more than 10 countries. 5 are recruiting or about to start. 11 of them are mainly about Giant Cell Tumor of Tendon Sheath (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Synovitis, Pigmented Villonodular too: 30 studies, 7 open.
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· Sites: 4 added, including Seoul and Busan
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Who runs them
Daiichi Sankyo (4) · AmMax Bio, Inc. (3) · Deciphera Pharmaceuticals, LLC (3) · Daiichi Sankyo Co., Ltd. (2) · Plexxikon (2) · Abbisko Therapeutics Co, Ltd (2) · Ono Pharmaceutical Co., Ltd. (1) · Novartis Pharmaceuticals (1)
Who develops what
Add to watchlistEvery program with a company-led study here in the last two years, whatever its size: 2 programs from 2 companies, 2 with this as their studies’ main aim; 1 with a live phase 3 study; 0 primary completions in the next 12 months.
Stage, biomarker and line of therapy are not read yet: these programs are in development here, not all in the same competitive position.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
None given by two companies or more yet.
Programs
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
The 2 programs — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.
Primary completion in the next 12 months (0)
Live phase 2 and 3 studies of these programs. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
None in the next 12 months.
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. US and EU rights, and Approved: from the regulators’ records (FDA’s Drugs@FDA via openFDA; EMA’s medicines data) — the holder of a marketed or authorized original, generics and other companies’ versions; not rights elsewhere, nor approval for this condition. Phase 4 trial recorded, where neither lists it: a phase 4 study exists somewhere. Not read yet: labels by indication, exclusivity, licenses, line of therapy, academic comparators, sales.
What is being tested here
Drugs under test in Giant Cell Tumor of Tendon Sheath studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Pimicotinib | 2 | 1 | 3 |
| Vimseltinib | 1 | 1 | 3 |
| Indocyanine Green | 1 | 0 | 1 |
| Pexidartinib | 0 | 2 | 5 |
| Anti-CSF1R Monoclonal Antibody AMB-05X | 0 | 0 | 3 |
| Nilotinib | 0 | 0 | 1 |
| Cabiralizumab | 0 | 0 | 1 |
| Lacnotuzumab | 0 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Dec 2026Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Tenosynovial Giant Cell Tumor Surgery · Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- Sep 2027MOVE: Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib · Deciphera Pharmaceuticals, LLC
Who these studies take
Of the 4 Giant Cell Tumor of Tendon Sheath studies recruiting now, 3 (75%) set no upper age limit and 1 (25%) stop at 75 or younger. 1 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 4 (100%) | 4 (100%) |
| 30 | 4 (100%) | 4 (100%) |
| 40 | 4 (100%) | 4 (100%) |
| 50 | 4 (100%) | 4 (100%) |
| 65 | 4 (100%) | 4 (100%) |
| 75 | 4 (100%) | 4 (100%) |
| 85 | 3 (75%) | 3 (75%) |
Across all 22 studies, recruiting or not: 9% stop at 75 or younger and 0% at 65; 9% take children; 0% are for women only and 0% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 16, 2026.
Stopped1
- A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) TreatmentWithdrawnNov 4, 2026NCT04635111
Studies
Recruiting first, then most recently updated. Showing 22 of 22. search them.
- A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in Patients With Advanced Solid TumorRecruitingNCT04192344Phase 12 countries
- Study of Pimicotinib in Japanese Participants With Tenosynovial Giant Cell Tumor (TGCT) (J-MANEUVER)RecruitingNCT07499362Phase 21 country
- A Study of DCC-3014 to Evaluate the Efficacy, Safety, and Pharmacokinetics in Subjects With TGCTNot yet recruitingNCT07832747Phase 21 country
- MOVE: Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With VimseltinibRecruitingNCT070754711 country
- Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Tenosynovial Giant Cell Tumor SurgeryRecruitingNCT07315841Phase 41 country
- Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorCompletedNCT01207492Phase 21 country
- A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) TreatmentWithdrawnNCT046351111 country
- A Study of the Efficacy and Safety of Pexidartinib in Adult Subjects With TGCTActive, not recruitingNCT04488822Phase 32 countries
- Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell TumorActive, not recruitingNCT03069469Phase 1/29 countries
- A Study of Pexidartinib in Tenosynovial Giant Cell Tumor in JapanCompletedNCT04703322Phase 21 country
- Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)Active, not recruitingNCT05804045Phase 37 countries
- Study of Vimseltinib for Tenosynovial Giant Cell TumorActive, not recruitingNCT05059262Phase 313 countries
- Study to Evaluate Discontinuation and Re-Treatment in Participants With Tenosynovial Giant Cell Tumor (TGCT) Previously Treated With PexidartinibCompletedNCT04526704Phase 47 countries
- A Study to Evaluate Safety and Efficacy of AMB-05X Injections in Subjects With TGCTCompletedNCT05349643Phase 23 countries
- An Open-Label Study of Intra-articular AMB-05X Injections in Subjects With Tenosynovial Giant Cell Tumor of the KneeCompletedNCT04731675Phase 24 countries
- A Phase 2 Study of Intravenous AMB-05X in Tenosynovial Giant Cell Tumor PatientsTerminatedNCT04938180Phase 23 countries
- Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)CompletedNCT02371369Phase 312 countries
- Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorCompletedNCT02471716Phase 1/26 countries
- Study of Pexidartinib in Participants With Moderate Hepatic Impairment Compared With Healthy ParticipantsCompletedNCT04223635Early Phase 11 country
- MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS)CompletedNCT01643850Phase 22 countries
- Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid TumorsTerminatedNCT01804530Phase 11 country
- A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorTerminatedNCT02673736Phase 11 country