Retinal Diseases clinical trials
The registry lists 333 studies for Retinal Diseases across more than 10 countries. 60 are recruiting or about to start. 99 of them are mainly about Retinal Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 26 narrower conditions too, such as Macular Degeneration: 4,401 studies, 696 open.
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Status
Who runs them
National Eye Institute (NEI) (19) · Novartis Pharmaceuticals (8) · Duke University (7) · Laboratoires Thea (7) · Optos, PLC (7) · Kodiak Sciences Inc (7) · Bayer (5) · Gyroscope Therapeutics Limited (5)
What is being tested here
Drugs under test in Retinal Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sepofarsen | 1 | 3 | 4 |
| IRX-101 | 1 | 1 | 2 |
| Minocycline | 1 | 1 | 2 |
| Montelukast | 1 | 0 | 1 |
| Semaglutide | 1 | 1 | 1 |
| Dapagliflozin | 1 | 0 | 1 |
| Ranibizumab | 0 | 6 | 18 |
| Tarcocimab tedromer | 0 | 6 | 6 |
| Aflibercept | 0 | 2 | 4 |
| Brolucizumab | 0 | 3 | 4 |
Drug classes tested here Angiogenesis inhibitors 23 · Corticosteroids 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD · Phase 3 · AbbVie
- Jan 2027Safety and Tolerability of IRX-101 in Patients Receiving Intravitreal Injections · Phase 3 · iRenix Medical, Inc.
- Nov 2027Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION) · Phase 3 · Laboratoires Thea
- Nov 2026CHOPXE - Analysis of Choriocapillaris Flow Deficits in Patients With Pseudoxanthoma Elasticum · University Hospital, Angers
- Dec 2026COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease · University of Wisconsin, Madison
- Dec 2026Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium · MediBeacon
- Dec 2026Vascular Reparative Mechanism in Diabetes · University of Alabama at Birmingham
- Dec 2026Intraoperative OCT Guidance of Intraocular Surgery II · Duke University
- Feb 2027Promising ROd-cone DYstrophy Gene therapY · SparingVision
- Feb 2027Study of the Involvement of Fatty Acids in Retinopathy of Prematurity: Relationship Between Retinopathy of Prematurity and the Rate of Expression of Transplacental Fatty Acid Receptors. · Centre Hospitalier Universitaire Dijon
Who these studies take
Of the 44 Retinal Diseases studies recruiting now, 30 (68%) set no upper age limit and 4 (9%) stop at 75 or younger. 16 (36%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 19 (43%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 14 (32%) | 14 (32%) |
| 18 | 33 (75%) | 33 (75%) |
| 30 | 35 (80%) | 35 (80%) |
| 40 | 38 (86%) | 38 (86%) |
| 50 | 42 (95%) | 42 (95%) |
| 65 | 41 (93%) | 41 (93%) |
| 75 | 41 (93%) | 41 (93%) |
| 85 | 39 (89%) | 39 (89%) |
Across all 333 studies, recruiting or not: 16% stop at 75 or younger and 12% at 65; 28% take children; <1% are for women only and 1% for men only; 29% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Retinal Diseases studies take
Of 18 phase 2 interventional studies under Retinal Diseases, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 24 mo19–38 · 18 studies | — | — |
| Interventional, no phase | 18 mo8–66 · 42 studies | — | — |
| Observational | 53 mo19–… · 53 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Studies
Recruiting first, then most recently updated. Showing 50 of 333. Browse all 333 → or search them.
- Cell Collection to Study Eye DiseasesRecruitingNCT014328471 country
- Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 GeneRecruitingNCT011451961 country
- Safety and Efficacy Study of IVB103 Injection in Subjects With Neovascular (Wet) Agerelated Macular Degeneration (nAMD).RecruitingNCT06737354Phase 11 country
- 4D Duke Microscope Integrated Optical Coherence Tomography in a Zeiss Artevo 800RecruitingNCT07024719Not applicable1 country
- National Eye Institute Biorepository for Retinal DiseasesRecruitingNCT014966251 country
- Longitudinal Observational Study of Diabetic Retinopathy Progression in Type 2 Diabetes PatientsRecruitingNCT074585161 country
- COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal DiseaseRecruitingNCT06380075Not applicable1 country
- Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)RecruitingNCT06891443Phase 310 countries
- Intraoperative OCT Guidance of Intraocular Surgery IIRecruitingNCT037132681 country
- ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent StudyEnrolling by invitationNCT05481827Phase 26 countries
- Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve CareRecruitingNCT07738874Not applicable1 country
- New Non-invasive Modalities for Assessing Retinal Structure and FunctionRecruitingNCT03475173Not applicable1 country
- Open-Label Study to Evaluate the Safety, Tolerability, and Efficacy of Gene Therapy (SPVN20) in Subjects With Rod-Cone DystrophyRecruitingNCT07807111Phase 1/23 countries
- Morpho-functional Evaluation of the Retina and Choroid Using Multimodal Imaging in Healthy Subjects and Patients With Retino-choroidal DiseasesNot yet recruitingNCT07615699
- Safety and Preliminary Efficacy of VG801 in Patients With ABCA4 Mutation-associated Retinal Dystrophy (Stargardt Disease)RecruitingNCT07002398Phase 1/21 country
- Study to Evaluate the Long-Term Safety of Ultevursen in Participants With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A GeneNot yet recruitingNCT07796646Phase 2
- SGLT2 Inhibitors in Geographic AtrophyRecruitingNCT07174687Phase 21 country
- Optimize Pediatric OCT ImagingRecruitingNCT061395231 country
- AOSLO Imaging for the Study of Cellular Alterations in Retinal NeurodegenerationNot yet recruitingNCT07725055Not applicable
- MIRACLE-T2D Montelukast Intervention for Renal, Cardiovascular and Eye Health in Type 2 DiabetesNot yet recruitingNCT07685886Phase 41 country
- Stem Cell Ophthalmology Treatment Study IIRecruitingNCT03011541Not applicable3 countries
- The Genetics Navigator: Evaluating a Digital Platform for Genomics Health ServicesRecruitingNCT06455384Not applicable1 country
- Collecting Data on Retinal Blood Blood Flow and Blood Vessel Shape/Appearance Using an Investigational Device, XyCAM CRE, and to Then Compare Those Images With Images Collected From a Patient's Routine Clinical Examination.Not yet recruitingNCT076417381 country
- Establishment of a Multimodal Standard Database for Inflammation-related OphthalmopathyRecruitingNCT076289461 country
- Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)RecruitingNCT07290244Phase 11 country
- Inherited Retinal Degenerative Disease RegistryRecruitingNCT024359401 country
- Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual PerformanceRecruitingNCT075489441 country
- Defining Retinal Structures Using Hyperspectral Retinal ImagingRecruitingNCT07555574Not applicable1 country
- Safety and Tolerability of IRX-101 in Patients Receiving Intravitreal InjectionsNot yet recruitingNCT05750589Phase 31 country
- Advancing Pediatric Retinal Imaging With Auto-aligned OCTRecruitingNCT06841575Not applicable1 country
- A Multimodal AI Agent for Ophthalmic Clinical Decision SupportNot yet recruitingNCT07401459Not applicable1 country
- Data Gathering for A10900RecruitingNCT071497401 country
- Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)RecruitingNCT068371811 country
- Reversal to Normoglycemia by Treating PrediabetesNot yet recruitingNCT07392151Phase 31 country
- Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein SodiumRecruitingNCT04008121Early Phase 11 country
- Longitudinal Prospective Natural History Study of Retinopathy in Zellweger Spectrum DisorderRecruitingNCT061906262 countries
- Wide Field OCTA in Ocular DiseasesNot yet recruitingNCT07298174
- CHOPXE - Analysis of Choriocapillaris Flow Deficits in Patients With Pseudoxanthoma ElasticumRecruitingNCT07006649Not applicable1 country
- Study of the Involvement of Fatty Acids in Retinopathy of Prematurity: Relationship Between Retinopathy of Prematurity and the Rate of Expression of Transplacental Fatty Acid Receptors.RecruitingNCT048198931 country
- Evaluation of Retinal Parameters in Patients With Epiretinal Membrane After VitrectomyEnrolling by invitationNCT07165626Not applicable1 country
- A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis PigmentosaNot yet recruitingNCT07082855Phase 31 country
- Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical ApplicationRecruitingNCT05724641Not applicable1 country
- An Interpretable Fundus Diseases Report Generating System Based On Weakly LabelingsNot yet recruitingNCT069180281 country
- A Long-Term Follow-Up Study in Subjects Who Received vMCO-I Administered Via Intravitreal InjectionEnrolling by invitationNCT059211621 country
- Retina BioBank: Retina Biomarkers for a Deeper Understanding of Vitreoretinal and Systemic DiseasesEnrolling by invitationNCT067966731 country
- Safety & Efficacy of Eyecyte-RPE™ in Patients With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration.RecruitingNCT06394232Phase 1/21 country
- Novel Glaucoma DiagnosticsRecruitingNCT002866371 country
- Safety and Efficacy of 18 mm Short Vitrectomy Probe for Pediatric Vitreoretinal SurgeriesRecruitingNCT06520410Phase 41 country
- Perfluorooctyl Bromide Which Empowers the Liquid to Flat the Detached Retina and Displace the Underneath Fluids AnteriorlyRecruitingNCT056990961 country
- Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid MetabolomicsEnrolling by invitationNCT064085711 country