Retinal Vein Occlusion clinical trials
The registry lists 289 studies for Retinal Vein Occlusion across more than 10 countries. 32 are recruiting or about to start. 156 of them are mainly about Retinal Vein Occlusion (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Status
Who runs them
Novartis Pharmaceuticals (19) · Allergan (16) · Bayer (9) · National Eye Institute (NEI) (7) · Shahid Beheshti University of Medical Sciences (5) · Hoffmann-La Roche (4) · Clearside Biomedical, Inc. (4) · Assiut University (4)
What is being tested here
Drugs under test in Retinal Vein Occlusion studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Faricimab | 1 | 3 | 3 |
| Chloroprocaine | 1 | 0 | 2 |
| Apraclonidine | 1 | 0 | 1 |
| Oxygen | 1 | 0 | 1 |
| Remigromig | 1 | 0 | 1 |
| Mecobalamin | 1 | 0 | 1 |
| Ranibizumab | 0 | 14 | 46 |
| Aflibercept | 0 | 4 | 18 |
| Dexamethasone | 0 | 4 | 14 |
| Bevacizumab | 0 | 7 | 13 |
Drug classes tested here Angiogenesis inhibitors 1 open · Local anesthetics 1 open · Corticosteroids 28
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jul 2027Efficacy and Safety Evaluation of SMO1 in Patients With Retinal Vein Occlusive Macular Edema · Phase 3 · SANGMYUNG innovation
- Nov 2027Combination of Ranibizumab and Targeted Laser Photocoagulation · Phase 3 · University of Giessen
- Nov 2026A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products · Hoffmann-La Roche
- Dec 2026Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium · MediBeacon
- Dec 2026Iopidine to Decrease Intraocular Pressure Rise After Injections · Retina Consultants of Delmarva
- Dec 2026Minimally Invasive Suprachoroidal Drainage for the Treatment of Neovascular Glaucoma · Zhongnan Hospital
- Dec 2026DATA-INSIGHT is a Project That Looks at Health Data in Germany to Find Out How Many Patients Suffer From Eye Disease. The Project Also Explores New Ways to Collect and Use Publicly Available Healthcare Information. · Bayer
- Mar 2027Robotic RVO Trial: Robot-assisted Retinal Vein Cannulation in Patients With Retinal Vein Occlusions · University of Oxford
- May 2027Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion Treatment · First Affiliated Hospital of Chongqing Medical University
- Jun 2027Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease · Johns Hopkins University
Who these studies take
Of the 18 Retinal Vein Occlusion studies recruiting now, 13 (72%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (6%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (22%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (6%) | 1 (6%) |
| 18 | 15 (83%) | 15 (83%) |
| 30 | 16 (89%) | 16 (89%) |
| 40 | 16 (89%) | 16 (89%) |
| 50 | 18 (100%) | 18 (100%) |
| 65 | 18 (100%) | 18 (100%) |
| 75 | 18 (100%) | 18 (100%) |
| 85 | 16 (89%) | 16 (89%) |
Across all 289 studies, recruiting or not: 3% stop at 75 or younger and 1% at 65; 10% take children; 0% are for women only and 0% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Retinal Vein Occlusion studies take
Of 19 phase 4 interventional studies under Retinal Vein Occlusion, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 22 mo14–29 · 14 studies | — | — |
| Phase 3 | 26 mo17–41 · 18 studies | — | — |
| Phase 4 | 35 mo19–47 · 19 studies | — | — |
| Interventional, no phase | 37 mo11–… · 22 studies | — | — |
| Observational | 52 mo18–69 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 289. Browse all 289 → or search them.
- A Case-Control Study Revealing Intraocular Microenvironment Characteristics in Patients With Ocular Diseases Based on Multi-Omics AnalysisNot yet recruitingNCT07897513
- National Eye Institute Biorepository for Retinal DiseasesRecruitingNCT014966251 country
- Iopidine to Decrease Intraocular Pressure Rise After InjectionsNot yet recruitingNCT07891910Phase 41 country
- Robotic RVO Trial: Robot-assisted Retinal Vein Cannulation in Patients With Retinal Vein OcclusionsRecruitingNCT07820761Not applicable1 country
- A Dose-masked Study of Intravitreal Remigromig (EYE103) in Participants With NVAMD or Macular Edema Following BRVORecruitingNCT07205887Phase 21 country
- Changes in Intraocular Pressure After Intravitreal InjectionNot yet recruitingNCT07826286
- A Phase I Study of GenSci148 Intravitreal Injection for Neovascular Age-related Macular Degeneration, Diabetic Macular Edema and Retinal Vein OcclusionNot yet recruitingNCT07817615Phase 11 country
- Emerging Indications for Hyperbaric Oxygen TreatmentNot yet recruitingNCT07240649Phase 4
- A Study on the Combination of Tongluo Huayu Formula in Treating RVO of Phlegm-Stasis Intertwinement Type: Based on the Mechanism of Systemic Metabolic Regulation Mediated by Gut MicrobiotaNot yet recruitingNCT07718503Not applicable1 country
- Efficacy and Safety Evaluation of SMO1 in Patients With Retinal Vein Occlusive Macular EdemaRecruitingNCT07708142Phase 31 country
- DATA-INSIGHT is a Project That Looks at Health Data in Germany to Find Out How Many Patients Suffer From Eye Disease. The Project Also Explores New Ways to Collect and Use Publicly Available Healthcare Information.RecruitingNCT073086391 country
- Optical Coherence Tomography Angiography in Subjects With Retinal Vascular DiseaseRecruitingNCT04505618Not applicable1 country
- AI vs. Physician for Anti-VEGF Decision-Making: An RCTNot yet recruitingNCT07328776Not applicable1 country
- Soluble Cluster of Differentiation 160 (sCD160) in Sera and Intra-ocular Fluids: Association With Ischaemic RetinopathiesRecruitingNCT03680794Not applicable1 country
- Retinal Clinical Assessment With AI-derived Quantitative InformationNot yet recruitingNCT07291960
- Serum Cholinesterases, Paraoxonase, and Cardiovascular Risk After Intravitreal BevacizumabRecruitingNCT075507771 country
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal InjectionsEnrolling by invitationNCT07456826Phase 41 country
- Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion TreatmentRecruitingNCT07133438Phase 41 country
- Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein SodiumRecruitingNCT04008121Early Phase 11 country
- Wide Field OCTA in Ocular DiseasesNot yet recruitingNCT07298174
- Safety and Proof of Concept Study of ANXV (Annexin A5) in Patients With Diabetic Retinopathy or Retinal Vein OcclusionRecruitingNCT07259928Phase 21 country
- High-throughput Large-model-based AI-assisted Diagnosis Using OCTNot yet recruitingNCT07249307
- Effect of Video Viewing on Intravitreal Injection ExperienceRecruitingNCT07002372Not applicable1 country
- Implementation of the Intravitreal Injection Administered by NursesEnrolling by invitationNCT065117001 country
- Optical Coherence Tomography in Retinal Vein OcclusionNot yet recruitingNCT06886893
- Evaluation of Therapeutic Efficacy of Faricimab for Clinical AMD, DME, and RVO PatientsRecruitingNCT06572553Phase 2/31 country
- Intraoperative Application of Fluorescein Sodium Angiography in Vascular RetinopathyNot yet recruitingNCT06343961Not applicable
- OCT and OCT-Angiography Biomarkers of Treatment Response to Dexamethasone Implant in Macular Edema Due to Retinal Vascular Diseases - DME and RVORecruitingNCT063326901 country
- Single-center Study Measuring OSDI Dry Eye Score in Patients Undergoing an Anti-VEGF Induction ProtocolRecruitingNCT062627371 country
- Ultra-wide-field Fluorescein Angiography in Patients With Macular Edema Secondary to Retinal Vein OcclusionRecruitingNCT041404481 country
- Ultra-wide-field Fluorescein Angiography in Patients With Retinal Vein OcclusionRecruitingNCT040756951 country
- NIR Fluorescence Molecular Imaging of ANXV-800CW in RVO PatientsRecruitingNCT05133791Phase 11 country
- Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study)Active, not recruitingNCT064395761 country
- A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology ProductsActive, not recruitingNCT0547692629 countries
- Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: Pain, Procedure Time, Patient Satisfaction, and SafetyActive, not recruitingNCT07481500Not applicable1 country
- Effectiveness of Intravitreal Injection of Aflibercept 8 mg in Resistant Diabetic Macular Edema, Retinal Vein Occlusion and Myopic Choroidal Neovascularisation PatientsCompletedNCT06879301Early Phase 11 country
- A 2-part Study Consisting of a Multiple Ascending Dose Safety Study in Participants With Macular Edema Following Branch Retinal Vein Occlusion and a Dose-finding Safety and Preliminary Efficacy Study in Participants With Either Diabetic Macular Edema or Neovascular Age-related Macular DegenerationCompletedNCT06664502Phase 1/22 countries
- Patient Comfort Following Intravitreal Injections Using Iheezo Versus Standard AnesthesiaCompletedNCT07779356Phase 41 country
- Near-Infrared Light Photobiomodulation Treatment for Retinal Vein Occlusion Macular OedemaTerminatedNCT04847869Not applicable1 country
- A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal DisordersCompletedNCT04516278Phase 31 country
- AI-Assisted Detection of Posterior Segment Diseases: DR, AMD, RVO, and GlaucomaCompletedNCT07318428Not applicable1 country
- A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)CompletedNCT05850520Phase 327 countries
- Study of the SCD411 Prefilled Syringe for Treating Adults With Wet Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema, or Diabetic RetinopathyCompletedNCT07501052Phase 21 country
- Combination of Ranibizumab and Targeted Laser PhotocoagulationActive, not recruitingNCT04444492Phase 32 countries
- A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal DisordersActive, not recruitingNCT05112861Phase 31 country
- Comparison of Intravitreal Anti-VEGF Treatment Burden in Different Retinal DiseasesCompletedNCT075145591 country
- A Phase III Study for 601 Versus Ranibizumab in Patients With Vision LossCompletedNCT05520177Phase 31 country
- Minimally Invasive Suprachoroidal Drainage for the Treatment of Neovascular GlaucomaActive, not recruitingNCT07201415Not applicable1 country
- Effect of Ozurdex® 0.7 mg on Improvement of Efficacy of Bevacizumab for Central Retinal Vein OcclusionCompletedNCT01295112Phase 2/31 country
- Clinical Characteristics of Neovascular GlaucomaCompletedNCT071778071 country