Drug

Aflibercept clinical trials

Also written Eylea, Zaltrap, VEGF Trap and AVE0005.

studies test it: 271
open now: 12
in phase 3: 58
first study started: 2001

Keep track of what changes. Save the aflibercept studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.

Watch these studies

How studies write it

Studies that test it under each name

Studies by the year they started

270 studies that test it; most in 2015 (30)

Studies that test aflibercept, by start year
Year	Studies
2001	1
2002	1
2004	2
2005	1
2006	11
2007	14
2008	7
2009	7
2010	2
2011	5
2012	21
2013	28
2014	27
2015	30
2016	24
2017	15
2018	13
2019	14
2020	10
2021	8
2022	7
2023	2
2024	8
2025	4
2026	8

By phase

A phase 1/2 study counts in both.

Early Phase 1: 2
Phase 1: 41
Phase 2: 98
Phase 3: 58
Phase 4: 78
No phase: 16

What it is tested for

Each study’s main condition, where its own words name it.

Macular Degeneration: 53
Macular Edema: 50
Colorectal Neoplasms: 20
Diabetic Retinopathy: 14
Polypoidal Choroidal Vasculopathy: 9
Wet Macular Degeneration: 7
Retinal Vein Occlusion: 7
Rectal Neoplasms: 6
Neoplasms: 6
Carcinoma: 4
Choroidal Neovascularization: 4
Lymphoma: 4

Who runs them

Industry 92 · Other 179

Regeneron Pharmaceuticals (26) · Bayer (21) · National Cancer Institute (NCI) (19) · Sanofi (19) · Unity Health Toronto (4) · Kim's Eye Hospital (3) · Amgen (3) · Hospices Civils de Lyon (3)

Often tested with

Tested in the same studies.

Ranibizumab (14) · Bevacizumab (6) · FOLFIRI-Ziv-aflibercept Regimen (3) · FOLFIRI Regimen (3) · Fluorouracil (2) · Capecitabine (2) · Docetaxel (2) · Verteporfin (2)

Studies

Open first, then newest update. How each study uses aflibercept is read from its arms, and is right about nine times in ten.

Testing it · 271

See all 271 studies that test aflibercept →

Given in every arm · 38 — aflibercept is usual care beside what is tested

Showing 20 of 38.

As the comparator · 94 — what is tested is compared with aflibercept

Showing 20 of 94.

Codes

What other systems call aflibercept · ClinicalTrials.gg INT005352

MeSH (NLM) C533178afliberceptConfirmed ClinicalTrials.gov, NLM
UNII (FDA) 15C2VL427DAFLIBERCEPTConfirmed FDA, NLM
RxNorm 1304475One source FDA
NCI Thesaurus C2682Ziv-AfliberceptOne source FDA

System	Code	Name there	Checked by
MeSH (NLM)	C533178	aflibercept	Confirmed ClinicalTrials.gov, NLM
UNII (FDA)	15C2VL427D	AFLIBERCEPT	Confirmed FDA, NLM
RxNorm	1304475	—	One source FDA
NCI Thesaurus	C2682	Ziv-Aflibercept	One source FDA

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.

Aflibercept clinical trials

How studies write it

Name

Brand

Development codes

Other names

Combined with it in one product