Retinal Perforations clinical trials
The registry lists 139 studies for Retinal Perforations across more than 10 countries. 22 are recruiting or about to start. 100 of them are mainly about Retinal Perforations (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28.
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Who runs them
Helse Stavanger HF (7) · Kyorin University (7) · Vienna Institute for Research in Ocular Surgery (5) · Samsung Medical Center (4) · Federal University of São Paulo (4) · Centre Hospitalier Universitaire Dijon (3) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (3) · Assistance Publique - Hôpitaux de Paris (3)
What is being tested here
Drugs under test in Retinal Perforations studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Platelet rich plasma | 1 | 0 | 1 |
| Microplasmin | 0 | 1 | 2 |
| Dexamethasone | 0 | 0 | 1 |
| Dorzolamide | 0 | 0 | 1 |
| Nepafenac | 0 | 1 | 1 |
| Bromfenac | 0 | 1 | 1 |
| Denufosol tetrasodium | 0 | 0 | 1 |
| OT-551 | 0 | 0 | 1 |
| Ranibizumab | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Autologous Tenon's Capsule Graft for Refractory Macular Holes · Benha University
- Dec 2026Intraoperative OCT Guidance of Intraocular Surgery II · Duke University
- Feb 2027Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes · The Filatov Institute of Eye Diseases and Tissue Therapy
- May 2027Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques · Kazakh Eye Research Institute
- Jun 2027Surgical Procedure Efficiency Evaluation stuDy · Alcon Research
Who these studies take
Of the 17 Retinal Perforations studies recruiting now, 15 (88%) set no upper age limit and 1 (6%) stop at 75 or younger. 5 (29%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (24%) | 4 (24%) |
| 18 | 15 (88%) | 15 (88%) |
| 30 | 15 (88%) | 15 (88%) |
| 40 | 15 (88%) | 15 (88%) |
| 50 | 16 (94%) | 16 (94%) |
| 65 | 17 (100%) | 17 (100%) |
| 75 | 16 (94%) | 16 (94%) |
| 85 | 16 (94%) | 16 (94%) |
Across all 139 studies, recruiting or not: 7% stop at 75 or younger and 1% at 65; 17% take children; 0% are for women only and 0% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Retinal Perforations studies take
Of 45 interventional studies with no phase under Retinal Perforations, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 28 mo12–31 · 45 studies | — | 28 mo12–31 · 45 studies |
| Observational | 26 mo7–144 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 139. Browse all 139 → or search them.
- Surgical Procedure Efficiency Evaluation stuDyRecruitingNCT072280911 country
- Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)RecruitingNCT07146516Not applicable1 country
- Intraoperative OCT Guidance of Intraocular Surgery IIRecruitingNCT037132681 country
- Autologous Tenon's Capsule Graft for Refractory Macular HolesRecruitingNCT07318961Not applicable1 country
- Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular HolesRecruitingNCT06433284Not applicable1 country
- Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)RecruitingNCT07633457Not applicable1 country
- Full-Thickness Macular Hole Surgery: A Comparison of Ten TechniquesRecruitingNCT07606404Not applicable1 country
- Retinal Clinical Assessment With AI-derived Quantitative InformationNot yet recruitingNCT07291960
- No Endotamponade for Macular Hole Repair: the NEMAR StudyRecruitingNCT06908824Not applicable3 countries
- Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular HolesEnrolling by invitationNCT06927544Not applicable1 country
- Comparison of Efficacy Between ILM ForcepsNot yet recruitingNCT06536569Phase 41 country
- Duration of Face Down Positioning for Full-Thickness Macular Hole RepairRecruitingNCT06000111Not applicable1 country
- Minimal Vitrectomy and ILM Flap with Sodium Hyaluronate Gel for MHEnrolling by invitationNCT06685328Not applicable1 country
- Small Macular Holes Treated With AirRecruitingNCT06211907Not applicable3 countries
- Novel Glaucoma DiagnosticsRecruitingNCT002866371 country
- PEELED INTERNAL LIMITING MEMBRANE REPOSITIONRecruitingNCT06359548Not applicable1 country
- Multimodal Imaging in Vitreo-retinal Surgery and Macular DystrophiesRecruitingNCT057471441 country
- Macular Micro Vascular Changes Following Macular Hole Repair : Optical Coherence Tomography Angiography StudyRecruitingNCT06233500Not applicable1 country
- GaslEss Macular Hole SurgeryNot yet recruitingNCT06079593Not applicable
- Treatment of Challenging Macular Holes Using Plasma Rich in Growth FactorsRecruitingNCT06115005Phase 21 country
- Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macular HoleRecruitingNCT06063005Not applicable1 country
- To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular Holes.RecruitingNCT05396209Not applicable1 country
- Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade AgentCompletedNCT07129798Not applicable1 country
- Outcomes of Macular Hole Surgery With Inverted Flap With vs Without Post op Posturing With SF6 in Macular Hole More Than 400 MicrometresActive, not recruitingNCT07787390Not applicable1 country
- Anatomical and Functional Outcomes of Pneumatic Retinopexy for Retinal Detachment: A 2-Year Case SeriesCompletedNCT077941631 country
- Autologous Tenon's Capsule Autograft for Large and Recurrent Full-Thickness Macular HolesCompletedNCT07760259Not applicable1 country
- DISCOVER Study: Microscope-integrated Intraoperative OCT StudyCompletedNCT024232131 country
- DEXTENZA in Pediatric Patients Following Retinal Surgery or Laser Treatment Under AnesthesiaCompletedNCT05620901Early Phase 11 country
- Early VItrectomy in DENse Spontaneous Vitreous HEmorrhageCompletedNCT04676256Not applicable1 country
- UNITY VCS Vitreoretinal SurgeryWithdrawnNCT07054281Not applicable1 country
- Evaluation of a New Surgical Technique for Macular Hole Which Was Not Closed After a Previous SurgeryTerminatedNCT02946372Not applicable1 country
- Head Position Monitoring After Pars Planar VitrectomyActive, not recruitingNCT069850301 country
- The Use of Amniotic Membrane or Internal Limiting Membrane for Large or Refractory Macular Holes: A Prospective StudyActive, not recruitingNCT04904679Not applicable1 country
- Postoperative Same Day Closure of Giant Macular Hole With Silicone OilCompletedNCT069159481 country
- Visual Acuity and Optical Coherence Tomography One Year After ILM-flap TranspositionCompletedNCT034658651 country
- Zeiss RESIGHT Disposable Lenses Evaluation StudyCompletedNCT05860985Not applicable1 country
- PIONEER: Intraoperative and Perioperative OCT StudyCompletedNCT024231611 country
- Clinical Characteristics and Surgical Outcomes of Full-thickness Macular Hole Without Focal Vitreomacular Traction.CompletedNCT06560710
- The (Flip and Fix) Internal Limiting Flap Technique Versus the Classic Temporal Flap for Macular Hole RepairCompletedNCT06441656Not applicable1 country
- Safety and Efficacy of Double Staining With Brilliant Blue G for Macular SurgeryTerminatedNCT01820520Phase 31 country
- Autologous Platelet-rich Plasma as a Treatment for Macular HolesCompletedNCT063239021 country
- Platelet-rich Fibrin(PRF) Membrane in Ophthalmic DiseasesActive, not recruitingNCT06200727Not applicable1 country
- Position Related Changes in Macular Hole Morphology Before and After SurgeryCompletedNCT04676217Not applicable1 country
- Ocular Coherence Tomography During Cataract AssessmentCompletedNCT052872691 country
- Optical Coherence Tomography Angiography Characteristics of Patients With Surgically Closed Full-thickness Idiopathic Macular Holes < 600 μm With Air Versus 10% SF6 TamponadeCompletedNCT05223205Not applicable1 country
- Corneal Flap Transplantation for Macular Hole Repair of High MyopiaActive, not recruitingNCT05875909Not applicable1 country
- Amniotic Membrane Visio-AMTRIX in Recurrent Macular HoleTerminatedNCT05191628Phase 21 country
- Double Flap Technique for Macular HoleCompletedNCT05269563Not applicable1 country
- Performance Comparison of the 25 Gauge 20,000cpm HYPERVIT Dual Blade vs. 10,000cpm ULTRAVIT Vitrectomy CutterCompletedNCT05710458Not applicable1 country
- Damages From Macular Grasping During Vitrectomy Comparing Traditional and 3D MicroscopeCompletedNCT05113212Not applicable1 country