Diabetic Retinopathy clinical trials
The registry lists 778 studies for Diabetic Retinopathy across more than 10 countries. 142 are recruiting or about to start. 588 of them are mainly about Diabetic Retinopathy (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 1,065 studies for Diabetic Retinopathy. How that becomes 778 here
This page counts the studies the registry files under Diabetic Retinopathy, and those it files under no condition that list Diabetic Retinopathythemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,065Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −63List Diabetic Retinopathy as a condition, but the registry did not file them under itMost often written as “Proliferative Diabetic Retinopathy” (41), “Non-Proliferative Diabetic Retinopathy” (9), and “Non Proliferative Diabetic Retinopathy” (2). The registry filed them under other conditions only, most often Vitreous Hemorrhage (13) and Macular Edema (9).
- −224Match it another way52 name it in the title, 8 in a keyword, and 164 by a synonym or other text the search reads.
- 778The count on this page94 of them list Diabetic Retinopathy in their own words; the registry filed them under no condition.
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Status
Who runs them
National Eye Institute (NEI) (25) · Association for Innovation and Biomedical Research on Light and Image (18) · University of Sao Paulo (14) · Novartis Pharmaceuticals (12) · National Taiwan University Hospital (11) · Jaeb Center for Health Research (11) · Zhongshan Ophthalmic Center, Sun Yat-sen University (10) · Sun Yat-sen University (10)
What is being tested here
Drugs under test in Diabetic Retinopathy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ranibizumab | 2 | 7 | 28 |
| Bevacizumab | 2 | 8 | 27 |
| Aflibercept | 2 | 3 | 16 |
| Dexamethasone | 2 | 1 | 8 |
| Faricimab | 2 | 0 | 2 |
| OLN324 | 2 | 2 | 2 |
| Chloroprocaine | 1 | 0 | 2 |
| Melatonin | 1 | 1 | 2 |
| Dexamethasone Intravitreal Implant | 1 | 1 | 2 |
| Insulin Glargine | 1 | 0 | 2 |
Drug classes tested here Angiogenesis inhibitors 8 open · Corticosteroids 2 open · NSAIDs 3 · Diuretics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027A Study to Evaluate the Efficacy and Safety of OTX-TKI (Axitinib Implant) in Participants With Non-Proliferative Diabetic Retinopathy · Phase 3 · Ocular Therapeutix, Inc.
- Nov 2026Analysis of DR Progression to Identify Risks and Need for Treatment · Association for Innovation and Biomedical Research on Light and Image
- Nov 2026Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling · Hejiang Ye
- Dec 2026Pre-operative Vabysmo in Patients With Non-clearing Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy · University of Colorado, Denver
- Dec 2026Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Supply Side · Orbis
- Dec 2026Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Demand Side · Orbis
- Dec 2026Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium · MediBeacon
- Dec 2026Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema · Carmen Clapp
- Dec 2026To Investigate the Feasibility and Acceptability of Trained Non-medical Professionals Performing Laser Treatment for Proliferative Diabetic Retinopathy (PDR), and the Potential Impact on Service Capacity. Assess Feasibility of Conducting a Full Trial Comparing Trained ECPs With Ophthalmologists · Swansea Bay University Health Board
- Dec 2026Iopidine to Decrease Intraocular Pressure Rise After Injections · Retina Consultants of Delmarva
Who these studies take
Of the 92 Diabetic Retinopathy studies recruiting now, 60 (65%) set no upper age limit and 10 (11%) stop at 75 or younger. 8 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 29 (32%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (8%) | 7 (8%) |
| 18 | 59 (64%) | 59 (64%) |
| 30 | 77 (84%) | 77 (84%) |
| 40 | 85 (92%) | 85 (92%) |
| 50 | 87 (95%) | 87 (95%) |
| 65 | 89 (97%) | 89 (97%) |
| 75 | 85 (92%) | 85 (92%) |
| 85 | 71 (77%) | 71 (77%) |
Across all 778 studies, recruiting or not: 15% stop at 75 or younger and 5% at 65; 11% take children; 0% are for women only and <1% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Diabetic Retinopathy studies take
Of 43 phase 2 interventional studies under Diabetic Retinopathy, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 31 mo17–37 · 43 studies | 30 mo16–37 · 30 studies | — |
| Phase 3 | 28 mo25–41 · 21 studies | — | — |
| Phase 4 | 24 mo14–37 · 32 studies | — | — |
| Interventional, no phase | 29 mo11–60 · 126 studies | — | 36 mo12–60 · 111 studies |
| Observational | 28 mo13–61 · 90 studies | — | 32 mo14–… · 73 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting2
- Leveraging Artificial Intelligence to Prevent Vision Loss From DiabetesOct 22, 2026NCT06763952
- A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic RetinopathyOct 15, 2026NCT06321302
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 778. Browse all 778 → or search them.
- A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)RecruitingNCT07705555Phase 34 countries
- A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic RetinopathyRecruitingNCT06321302Phase 29 countries
- A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)RecruitingNCT07705607Phase 34 countries
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic RetinopathyRecruitingNCT07588100Phase 11 country
- To Investigate the Feasibility and Acceptability of Trained Non-medical Professionals Performing Laser Treatment for Proliferative Diabetic Retinopathy (PDR), and the Potential Impact on Service Capacity. Assess Feasibility of Conducting a Full Trial Comparing Trained ECPs With OphthalmologistsRecruitingNCT07923292Not applicable1 country
- Implementing AI-based Glaucoma Screening Within Federally Qualified Health CentersRecruitingNCT06629649Not applicable1 country
- Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular EdemaRecruitingNCT07592273Phase 2/32 countries
- A Randomized, Phase 2 Study of Oral BGE-102 in Participants With Center-Involved Diabetic Macular EdemaRecruitingNCT07812090Phase 21 country
- A Case-Control Study Revealing Intraocular Microenvironment Characteristics in Patients With Ocular Diseases Based on Multi-Omics AnalysisNot yet recruitingNCT07897513
- Human iPSC for Repair of Vasodegenerative Vessels in Diabetic RetinopathyRecruitingNCT034036991 country
- National Eye Institute Biorepository for Retinal DiseasesRecruitingNCT014966251 country
- Longitudinal Observational Study of Diabetic Retinopathy Progression in Type 2 Diabetes PatientsRecruitingNCT074585161 country
- Iopidine to Decrease Intraocular Pressure Rise After InjectionsNot yet recruitingNCT07891910Phase 41 country
- Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Demand SideRecruitingNCT06968611Not applicable1 country
- Leveraging Artificial Intelligence to Prevent Vision Loss From DiabetesRecruitingNCT06763952Not applicable1 country
- Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Supply SideRecruitingNCT06968637Not applicable1 country
- Intraoperative OCT Guidance of Intraocular Surgery IIRecruitingNCT037132681 country
- Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAIONRecruitingNCT05147701Phase 12 countries
- Continuous Delivery of Ranibizumab Via the Port Delivery System for Proliferative Diabetic Retinopathy-related Vitreous Hemorrhage With Pars Plana Vitrectomy and Limited PRP.Not yet recruitingNCT07864480Phase 41 country
- Pivotal Trial for an Automated AI-based System for Detection of Diabetic RetinopathyRecruitingNCT078443171 country
- Corticosteroid for Diabetic Macular Edema (DME) StudyRecruitingNCT07843849Phase 41 country
- Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)RecruitingNCT034036861 country
- Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-03)Not yet recruitingNCT07842016Phase 3
- Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-02)Not yet recruitingNCT07841899Phase 3
- ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2RecruitingNCT05463289Not applicable1 country
- A Multicenter Randomized Double-Blind Trial of Chrocare CDSS for Integrated Management of Type 2 DiabetesNot yet recruitingNCT07833228Not applicable1 country
- A Study Intravitreal THN391 in Diabetic Macular Oedema Secondary to Non-Proliferative Diabetic Retinopathy.RecruitingNCT06701721Phase 12 countries
- Screening for Diabetic RETINopathy Using a Non-mydriatic Retinograph Funduscope in Occupational MEDicineNot yet recruitingNCT07828821Not applicable1 country
- Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDRRecruitingNCT06790784Phase 31 country
- Clinical Applications of Advanced Ophthalmic ImagingRecruitingNCT03135327Not applicable1 country
- Patients With Type 2 DiabetesRecruitingNCT072450821 country
- Glycemic Velocity and Early Retinal Microvascular Change With GLP-1RA Versus SGLT2i Initiation in Type 2 Diabetes (GLIDE)Not yet recruitingNCT077238201 country
- Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General PracticeRecruitingNCT07015034Not applicable1 country
- High Resolution Imaging OCT StudyRecruitingNCT07338461Not applicable1 country
- Validation of the Artificial Intelligence Subsystem of the DDART Medical Device for the Automated Detection of Lesions Compatible With Diabetic Retinopathy in a Random Sample of Retinal Fundus PhotographsRecruitingNCT077585821 country
- Assessment of Retinal Microvascular Changes by OCT Angiography in Diabetic RetinopathyRecruitingNCT077474281 country
- Observation of Iris Blood Flow Via OCTA in Diabetic Neovascular GlaucomaRecruitingNCT077229101 country
- Relation Between Glycemic Control and Retinal Microvascular Changes in Diabetic Patients Using OCTANot yet recruitingNCT07726381
- Biomarker of Diabetic RetinopathyRecruitingNCT050793991 country
- Effectiveness and Cost-Effectiveness Evaluations of AI-Assisted Diagnostic Software (VeriSee) for Ophthalmic Disease ScreeningRecruitingNCT06843499Not applicable1 country
- Artificial Intelligence-Aided Screening for Patients With Diabetic Retinopathy and Age-related Macular Degeneration in Family Medicine and Geriatric Medicine Outpatient ClinicsRecruitingNCT07069647Not applicable1 country
- Video Intervention to Improve Understanding of Diabetic Retinopathy at Zuckerberg San Francisco General Hospital and Trauma CenterNot yet recruitingNCT07519707Not applicable1 country
- Pediatric Artificial Intelligence for Retinopathy Screening in Children With Type 1 DiabetesRecruitingNCT07149142Not applicable1 country
- Optical Coherence Tomography Angiography in Subjects With Retinal Vascular DiseaseRecruitingNCT04505618Not applicable1 country
- To Evaluate the Efficacy and Safety of N-acetyl Cysteine Administration in Patients With Diabetic RetinopathyRecruitingNCT07634991Phase 41 country
- Village-Integrated Eye Worker Trial IIRecruitingNCT03752840Not applicable1 country
- Home- vs Hospital-based Care of Anti-VEGF Treatment for Diabetic Macular Edema: Non-inferiority RCTRecruitingNCT06610747Not applicable1 country
- Community-Based Eye Screening With Structured Referral Tracking for Preventing Avoidable Blindness in Adults in Rawalpindi, PakistanNot yet recruitingNCT07611682Not applicable1 country
- Proteomic Biomarker Identification in Age-Related Macular Degeneration, Diabetic Retinopathy and Retinal DetachmentRecruitingNCT07500324Not applicable1 country
- Pre-operative Vabysmo in Patients With Non-clearing Vitreous Hemorrhage Secondary to Proliferative Diabetic RetinopathyEnrolling by invitationNCT06191094Phase 41 country