Optic Neuritis clinical trials
The registry lists 88 studies for Optic Neuritis across more than 10 countries. 16 are recruiting or about to start. 47 of them are mainly about Optic Neuritis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28. Counting its narrower condition Neuromyelitis Optica too: 249 studies, 88 open.
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Who runs them
Fondation Ophtalmologique Adolphe de Rothschild (7) · Alexion Pharmaceuticals, Inc. (4) · University Hospital, Lille (3) · Hospices Civils de Lyon (3) · First Affiliated Hospital of Guangxi Medical University (3) · National Eye Institute (NEI) (3) · Medical University of Vienna (2) · University of Calgary (2)
What is being tested here
Drugs under test in Optic Neuritis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6, phase 3 first
- Dec 2026Azathioprine in MOGAD · Phase 3 · Hospices Civils de Lyon
- Dec 2026Modified Zipper Therapy for AQP4-IgG Positive Neuromyelitis Optica Spectrum Disorder · Phase 3 · Tianjin Medical University General Hospital
- Dec 2026Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis · Technical University of Munich
- Apr 2027VIsual Pathways Model in Neuro-inflammatory Disorders · University Hospital, Lille
- Jun 2027Efgartigimod for the Treatment of Acute Optic Neuritis · Anastasia Vishnevetsky, MD, MPH
- Nov 2027Evaluation of Optic Neuritis Using Synthetic Quantitative MRI · Fondation Ophtalmologique Adolphe de Rothschild
Who these studies take
Of the 14 Optic Neuritis studies recruiting now, 7 (50%) set no upper age limit and 6 (43%) stop at 75 or younger. 2 (14%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (14%) | 2 (14%) |
| 18 | 14 (100%) | 14 (100%) |
| 30 | 14 (100%) | 14 (100%) |
| 40 | 13 (93%) | 13 (93%) |
| 50 | 13 (93%) | 13 (93%) |
| 65 | 10 (71%) | 10 (71%) |
| 75 | 8 (57%) | 8 (57%) |
| 85 | 7 (50%) | 7 (50%) |
Across all 88 studies, recruiting or not: 53% stop at 75 or younger and 49% at 65; 16% take children; 0% are for women only and 0% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.TerminatedOct 23, 2026NCT05353413
Studies
Recruiting first, then most recently updated. Showing 50 of 88. Browse all 88 → or search them.
- Efgartigimod for the Treatment of Acute Optic NeuritisRecruitingNCT06453694Phase 21 country
- Prospective Evaluation of the 2022 Optic Neuritis Criteria When Optic Neuritis Is SuspectedRecruitingNCT076232521 country
- Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)RecruitingNCT07100990Phase 31 country
- Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation ResearchRecruitingNCT07623668Phase 31 country
- Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic ToolNot yet recruitingNCT077042941 country
- Modified Zipper Therapy for AQP4-IgG Positive Neuromyelitis Optica Spectrum DisorderRecruitingNCT07420296Phase 31 country
- Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)RecruitingNCT02521311Phase 21 country
- VIsual Pathways Model in Neuro-inflammatory DisordersRecruitingNCT054879891 country
- Retinal Neuro-vascular Coupling in Patients With Multiple SclerosisRecruitingNCT03401879Not applicable1 country
- Evaluation of Optic Neuritis Using Synthetic Quantitative MRINot yet recruitingNCT06916182
- Edaravone in the Treatment of Optic NeuritisRecruitingNCT05540262Not applicable1 country
- Azathioprine in MOGADRecruitingNCT05349006Phase 31 country
- Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)RecruitingNCT050171421 country
- Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple SclerosisRecruitingNCT06389968Not applicable1 country
- Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic NerveRecruitingNCT0560595117 countries
- Optic Neuritis Differential Diagnosis StudyRecruitingNCT03370965Not applicable1 country
- Biobank For MS And Other Demyelinating DiseasesActive, not recruitingNCT004453671 country
- Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.TerminatedNCT05353413Not applicable1 country
- Adjunctive Gypenosides for Acute Optic NeuritisTerminatedNCT02976766Phase 21 country
- Visual (Path)Ways in Multiple Sclerosis - Part IICompletedNCT06776224Not applicable1 country
- Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS)CompletedNCT04289909Not applicable1 country
- The Longitudinal CONQUER Study of Rare Neuroimmunologic DisordersActive, not recruitingNCT016230761 country
- Linking Optic Nerve MRI and the Retinal Axonal Loss After Optic NeuritisCompletedNCT036513621 country
- An Efficacy and Safety Study of Ravulizumab in Adult Participants With NMOSDCompletedNCT04201262Phase 313 countries
- OCS-05 in Patients With Optic NeuritisCompletedNCT04762017Phase 21 country
- Building Research With Artificial Intelligence in Neuro-OphthalmologyCompletedNCT063905791 country
- CHRONIC OPTIC NEUROPATHY IN MULTIPLE SCLEROSISCompletedNCT02543788Not applicable1 country
- Optical Coherence Tomography and Optic Neuritis Not Related to Multiple SclerosisCompletedNCT039633101 country
- A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum DisorderTerminatedNCT04155424Phase 2/37 countries
- High-Dose Vitamin D Induction in Optic NeuritisTerminatedNCT03302585Phase 21 country
- A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple SclerosisCompletedNCT04626921Phase 2/31 country
- A Trial of Neuroprotection With ACTH in Acute Optic NeuritisTerminatedNCT01838174Phase 41 country
- The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CISCompletedNCT03451955Not applicable1 country
- Diagnosis of ON With or Without MS or NMOSDTerminatedNCT041317641 country
- Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?CompletedNCT03570385Not applicable1 country
- Natural History of Optic NeuritisTerminatedNCT018514342 countries
- Fampridine-SR and Optic Neuritis RecoveryStatus unknownNCT04148781Early Phase 11 country
- Initial Clinical Presentation of Inflammatory Optic Neuritis Associated or Not With Autoantibodies Anti-Myelin-oligodendrocyte-glycoproteinCompletedNCT033455371 country
- An Open Label Extension Trial of Eculizumab in Relapsing NMO PatientsCompletedNCT02003144Phase 320 countries
- Ocular Manifestations in Rheumatic DiseasesCompletedNCT03753893
- The French Cohort and Biobank of Devic's Neuromyelitis Optica and Related Neurological Disorders (NMOSD) (NOMADMUS)CompletedNCT028507051 country
- Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic NeuritisStatus unknownNCT03586557Not applicable1 country
- Visual Reconstitution Therapy After Optic NeuritisCompletedNCT01274702Phase 21 country
- Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis TrialStatus unknownNCT04942002Phase 2/31 country
- Repetitive Transorbital Alternating Current Stimulation in Acute Autoimmune Optic NeuritisTerminatedNCT03862313Not applicable1 country
- Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)CompletedNCT047930871 country
- 3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON)CompletedNCT047928661 country
- Epidemiologic and Clinical Characteristics of Optic Neuritis in ChinaStatus unknownNCT042577341 country
- Ampyra for Optic Neuritis in Multiple SclerosisCompletedNCT01337986Phase 2/31 country
- Electric Stimulation of the Eye to Improve Vision After TraumaCompletedNCT02019927Not applicable1 country