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CompletedNCT03963310OCTON2Updated Jun 25, 2025

Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis

An observational study in Optic Neuritis, sponsored by Fondation Ophtalmologique Adolphe de Rothschild. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-25.

Sponsored by Fondation Ophtalmologique Adolphe de Rothschild · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
38
Ages
18 Years and older
Sex
All
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Study summary

The visual prognosis of optic neuritis not related to multiple sclerosis is unknown, both in terms of functional recovery and evolution.

This prospective cohort study aim to assess the ophthalmological evolution of patients presenting an episode of optic neuritis (NO) not related to a multiple sclerosis or to a clinically isolated syndrome.

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Conditions studied

  • Optic Neuritis

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03

In context

Optic Neuritis

88 studies on the registry are indexed under Optic Neuritis; 16 are open to participants now.

This study's enrollment of 38 is below the median of 150 across 25 observational studies indexed under Optic Neuritis.

Browse Optic Neuritis studies →

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild is the lead sponsor of 316 studies on the registry; 78 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients seen at the Adolphe de Rothschild Foundation for the first onset of an optic neuritis not related to multiple sclerosis and clinically isolated syndrome

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • First onset of an optic neuritis lasting for less than 1 month
  • With a brain MRI that does not meet the MS criteria

Exclusion criteria

Exclusion Criteria:

  • to MRI
  • Pregnant or lactating woman
  • History of known ipsilateral optic neuritis
  • Ophthalmologic comorbidity in the ipsilateral eye that may interfere with the interpretation of the examinations
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
38 participants (actual)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Visual acuity (ETDRS scale)

    Evolution over 1 year of the ophthalmological parameters of patients treated for an episode of optic neuritis not related to multiple sclerosis or a clinically isolated syndrome

    Time frame: 1 year

  2. Thickness of the layers of the retina with Optical Coherent Tomography(OCT),

    Time frame: 1 year

  3. Standard Humphrey Visual Field Test

    Time frame: 1 year

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Study locations

1 site
  • Fondation A. de Rothschild
    Paris, 75019, France
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03963310
Responsible party
Sponsor
First posted
May 24, 2019
Start date
Sep 14, 2020
Primary completion
May 23, 2024
Completion
May 23, 2024
Last update
Jun 25, 2025

Study contacts

Romain DESCHAMPS, MD
principal investigator · Fondation A. de Rothschild

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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