ClinicalTrials.gg
CompletedNCT03753893Updated Apr 12, 2022

Ocular Manifestations in Rheumatic Diseases

An observational study in Uveitis, Conjunctivitis and Keratoconjunctivitis Sicca, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. Completed. Per ClinicalTrials.gov, last updated 2022-04-12.

Primary conditionIridocyclitisRegistry: UveitisReclassifiedWhy we changed it
Registry
Uveitis — the first condition term the registry derived for this study.
ClinicalTrials.gg
Iridocyclitis
Why
  1. The study's listed conditions name Iridocyclitis, a narrower term within Uveitis.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Observational

Study type
Observational
Model
Ecologic or community
Time perspective
Retrospective
Enrollment
5,000
Sex
All
01

Study summary

This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis.

Read the detailed description

For the purposes of determining the prevalence of ocular complications in inflammatory rheumatic diseases, the following search terms were used: conjunctivitis, keratoconjunctivitis sicca, xerophthalmia, uveitis, eye hemorrhage, optic neuritis, papilledema, orbital disease, retinal artery/vein occlusion, macular edema, retinitis, chorioretinitis, scleritis, iridocyclitis, choroid hemorrhage, blindness and amaurosis fugax.

These terms were searched in the context of a corresponding inflammatory disease on Medline, Cochrane and Web of Science from their inception (1966, 1991 and 1990 respectively) until the point of study completion.

Studies were included if they provided numerical data of the prevalence or incidence of ocular manifestations in an inflammatory rheumatic disease. Studies were excluded if they were review articles, case reports where all patients experienced the same ocular comorbidity, if different comorbidities were not grouped independently, and if the study reported on fewer than 20 patients. When the same study cohort was used in more than one analysis, the most recent or largest sample-size study was included. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was used to assess the quality of cohort, case-control, and cross-sectional studies.

02

Conditions studied

  • Uveitis
  • Conjunctivitis
  • Keratoconjunctivitis Sicca
  • Xerophthalmia
  • Eye Hemorrhage
  • Optic Neuritis
  • Papilledema
  • Orbital Diseases
  • Retinal Vein Occlusion
  • Retinal Artery Occlusion
  • Macular Edema
  • Retinitis
  • Chorioretinitis
  • Iridocyclitis
  • Scleritis
  • Choroid Hemorrhage
  • Blindness
  • Amaurosis Fugax
03

In context

Iridocyclitis Reclassified

4 studies on the registry are indexed under Iridocyclitis; 1 is open to participants now.

Browse Iridocyclitis studies →

Lead sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's is the lead sponsor of 331 studies on the registry; 137 are open to participants now.

Compared within Iridocyclitis, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Uveitis. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Patients with ocular involvement in inflammatory rheumatic disease

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Studies were included if they provided numerical data of the prevalence or incidence of ocular manifestations in inflammatory rheumatic disease

Exclusion criteria

Exclusion Criteria:

  • review articles,
  • case reports where all patients experienced the same ocular comorbidity
  • if different comorbidities were not grouped independently
  • if the study reported on fewer than 20 patients
05

Study design

Observational model
Ecologic or community
Time perspective
Retrospective
Enrollment
5,000 participants (actual)
Patient registry
No

Interventions

  • OtherNo intervention used

    no intervention used

06

What researchers measure

Primary outcomes

  1. Prevalence of ocular manifestations of inflammatory rheumatic diseases

    Prevalence of ocular manifestations of inflammatory rheumatic diseases

    Time frame: data is collected once per year up to 2020

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from May 2013 to primary completion in Apr 2021, 95 months.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 31, 2018
First posted
Nov 27, 2018
StartActual
May 1, 2013
Primary completionActual
Apr 1, 2021
CompletionActual
Nov 1, 2021
Last update
Apr 12, 2022
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 12, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03753893
Responsible party
Janet Pope (Professor of Medicine, London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's) — Principal investigator
First posted
Nov 27, 2018
Start date
May 1, 2013
Primary completion
Apr 1, 2021
Completion
Nov 1, 2021
Last update
Apr 12, 2022

Study contacts

Janet Pope, MD
principal investigator · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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