An interventional study of Neuroimaging and VEP - visual evoked potential in Ischemic Optic Neuropathy, Optic Neuritis and Compressive Optic Neuropathy, sponsored by Medical University of Bialystok. Terminated at 1 site in Poland. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-23.
Sponsored by Medical University of Bialystok · Not applicable, Interventional, and Diagnostic
Study terminated prematurely due to lack of funding. Seven patients with optic neuropathies were enrolled; no healthy volunteers were enrolled.
The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging
Original planned protocol:
In this study, it is planned to find twenty volunteers for each of the neuropathies and twenty healthy volunteers. Each volunteer will undergo clinical tests such as visual acuity, color vision, intraocular pressure measurement, assessment of the anterior chamber and fundus using a slit lamp and Volk lens, macular optical coherence tomography examination and examination of the optic nerve disc (OCT), neurological field vision and visual evoked potential (VEP) testing. Each of the volunteers will undergo magnetic resonance imaging. During active scanning, patients will be asked for not blinking or moving their heads by staring at the red dot on the outside of the camera reflected in the coil mirror. The obtained diffusion tensor data will be used for further analysis.
Actual study conduct:
The study was terminated prematurely due to lack of funding. Seven patients with optic neuropathies were enrolled; no healthy volunteers were enrolled. All participant measurements, including those for the primary outcome, were completed on March 6, 2026. Data analysis continued after the completion of participant measurements.
55 studies on the registry are indexed under Optic Neuropathy, Ischemic; 11 are open to participants now.
This study's enrollment of 7 is below the median of 40 across 35 interventional studies indexed under Optic Neuropathy, Ischemic.
Browse Optic Neuropathy, Ischemic studies →Medical University of Bialystok is the lead sponsor of 72 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The criteria were revised on the registry on Oct 23, 2026. See what changed
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
- Common to MRI (presence of pacemaker, non-MRI-safety or claustrophobia).
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with various types of optic neuropathy.
Device: Neuroimaging · Diagnostic Test: VEP - visual evoked potential · Diagnostic Test: Ophthalmology examination.
Healthy volunteers
Device: Neuroimaging · Diagnostic Test: VEP - visual evoked potential · Diagnostic Test: Ophthalmology examination.
Magnetic resonance diffusion tensor imaging of the brain
Electrophysiology of the visual pathway.
Full ophthalmological examination (visual acuity, color vision, measurement of intraocular pressure, evaluation of the anterior chamber and the fundus of the eye using a slit lamp and the Volk lens, optical coherence tomography examination of the macula and optic nerve disc (OCT), neurological field vision)
sigma parameter
sigma parameter in our algorithm provides a quantitative measure of nerve atrophy
Time frame: Periprocedural (single MRI examination)
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2020 to primary completion in Mar 2026, 74 months.
Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 23, 2026: primary completion Jan 2024 → Mar 2026 and completion Jan 2024 → Mar 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
Study terminated prematurely due to lack of funding. Seven patients with optic neuropathies were enrolled; no healthy volunteers were enrolled.
Study terminated prematurely due to lack of funding. Seven patients with optic neuropathies were enrolled; no healthy volunteers were enrolled.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is terminated, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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Medical University of Bialystok