ClinicalTrials.gg
RecruitingNCT07335211Updated Jan 13, 2026

Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

A Phase 3 interventional study of HUC3-637 and HUC3-637-R in Primary Open Angle Glaucoma (POAG) and Ocular Hypertension, sponsored by Huons Co., Ltd.. Recruiting at 1 site in South Korea. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-01-13.

Sponsored by Huons Co., Ltd. (part of Huons Global) · Phase 3, Interventional, and Treatment

Phase
Phase 3
Study type
Interventional
Enrollment
206
Allocation
Randomized
Ages
19 Years and older
Sex
All
01

Study summary

A multicenter, randomized, single-blind, active controlled, phase III clinical trial to evaluate the efficacy and safety of HUC3-637 in patients with primary open angle glaucoma or ocular hypertension

02

Conditions studied

  • Primary Open Angle Glaucoma (POAG)
  • Ocular Hypertension
03

In context

Glaucoma, Open-Angle

924 studies on the registry are indexed under Glaucoma, Open-Angle; 117 are open to participants now.

This study's planned enrollment of 206 is above the median of 80 across 692 interventional studies indexed under Glaucoma, Open-Angle.

Browse Glaucoma, Open-Angle studies →

Lead sponsor

Huons Co., Ltd. is the lead sponsor of 29 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adults aged 19 years and older
  • Participants diagnosed with POAG or OH
  • Have fully explained and understood the study and have voluntarily given written .

Exclusion criteria

Exclusion Criteria:

  • Acute or chronic angle-closure glaucoma
  • Congenital glaucoma, secondary glaucoma (open-angle glaucoma)
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Investigator)
Enrollment
206 participants (estimated)

Study arms

  • Experimental
    HUC3-637

    Dorzolamide, Timolol

    Drug: HUC3-637

  • Active comparator
    HUC3-637-R

    Dorzolamide, Timolol

    Drug: HUC3-637-R

Interventions

  • DrugHUC3-637

    Ophthalmic solution instilled directly into the eye (topical ocular administration)

  • DrugHUC3-637-R

    Ophthalmic solution instilled directly into the eye (topical ocular administration)

06

What researchers measure

Primary outcomes

  1. Mean change in diurnal IOP

    Time frame: 12 week

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Jan 2026; primary completion for Nov 2027, 22 months later.

Of 47 industry-sponsored phase 3 interventional studies under Glaucoma, Open-Angle, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 39. This study's planned 22 months is below that.

Counting every sponsor, half of 49 studies reached it within 25 months; a quarter within 12 and three quarters within 39.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 5, 2026
First posted
Jan 13, 2026
StartEst.
Jan 2026
Primary completionEst.
Nov 2027
CompletionEst.
Dec 2027
Last update
Jan 13, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jan 13, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07335211
Lead sponsor
Huons Co., Ltd.
Responsible party
Sponsor
First posted
Jan 13, 2026
Start date
Jan 2026 (estimated)
Primary completion
Nov 2027 (estimated)
Completion
Dec 2027 (estimated)
Last update
Jan 13, 2026

Study contacts

Rang Lee
Contact
rlee@huons.com
07074926091

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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