Melanosis clinical trials
The registry lists 170 studies for Melanosis across more than 10 countries. 46 are recruiting or about to start. 144 of them are mainly about Melanosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05. Counting its 2 narrower conditions too, such as Peutz-Jeghers Syndrome: 217 studies, 56 open.
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Who runs them
Assiut University (11) · Cosmetique Active International (9) · Centre Hospitalier Universitaire de Nice (6) · Universidad Autonoma de San Luis Potosí (6) · Indonesia University (5) · Combined Military Hospital Abbottabad (5) · Northwestern University (4) · Galderma R&D (4)
What is being tested here
Drugs under test in Melanosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tranexamic Acid | 6 | 5 | 16 |
| Metformin | 2 | 0 | 3 |
| Melatonin | 1 | 0 | 2 |
| Niacinamide | 1 | 0 | 2 |
| Ascorbic Acid | 1 | 0 | 1 |
| Resveratrol | 1 | 0 | 1 |
| Isotretinoin | 1 | 0 | 1 |
| Tretinoin | 0 | 1 | 4 |
| Azelaic acid | 0 | 0 | 3 |
| Platelet rich plasma | 0 | 1 | 3 |
Drug classes tested here Corticosteroids 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Feb 2027Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma · Phase 3 · Assiut University
- Nov 2026Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma · Hayatabad Medical Complex
- Nov 2026Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis · Nanjing First Hospital, Nanjing Medical University
- Dec 2026Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma · Foundation University Islamabad
- Dec 2026Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma · Foundation University Islamabad
- Jan 2027Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma · Combined Military Hospital Abbottabad
- Jan 2027Topical Metformin Versus Triple Regimen for Epidermal Melasma · Combined Military Hospital, Pakistan
- Jan 2027Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation · Brainfarma Industria Química e Farmacêutica S/A
- Feb 2027New Treatment in Melasma · Sohag University
- Jun 2027Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma · Allied Hospital Faisalabad
Who these studies take
Of the 19 Melanosis studies recruiting now, 8 (42%) set no upper age limit and 11 (58%) stop at 75 or younger. 1 (5%) take children under 18. 6 (32%) are for women only and 0 (0%) for men only; 13 (68%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (5%) | 1 (5%) |
| 18 | 13 (68%) | 11 (58%) |
| 30 | 19 (100%) | 13 (68%) |
| 40 | 19 (100%) | 13 (68%) |
| 50 | 18 (95%) | 12 (63%) |
| 65 | 11 (58%) | 9 (47%) |
| 75 | 8 (42%) | 7 (37%) |
| 85 | 8 (42%) | 7 (37%) |
Across all 170 studies, recruiting or not: 67% stop at 75 or younger and 54% at 65; 4% take children; 34% are for women only and 0% for men only; 38% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Melanosis studies take
Of 53 interventional studies with no phase under Melanosis, half reached primary completion within 9 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 9 mo5–18 · 53 studies | — | 9 mo5–18 · 33 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered5
- Efficacy and Safety of Triple-Combination Cream Plus Microneedling Along With Tranexamic Acid Versus Platelet-Rich Plasma in the Treatment of Moderate-to-Severe Melasma: A Randomized Comparative StudyOct 23, 2026NCT07893067
- COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMAOct 22, 2026NCT07890571
- New Treatment in MelasmaOct 21, 2026NCT07887399
- Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial MelasmaOct 19, 2026NCT07881328
- To Evaluate the Effectiveness of Topical Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% as Compared to Topical Tretinoin 0.05% + Hydroquinone 4% + Fluocinolone 0.01% for the Treatment of MelasmaOct 15, 2026NCT07876323
Studies
Recruiting first, then most recently updated. Showing 50 of 170. Browse all 170 → or search them.
- Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for MelasmaEnrolling by invitationNCT07696806Phase 41 country
- COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMANot yet recruitingNCT07890571Not applicable1 country
- New Treatment in MelasmaNot yet recruitingNCT07887399Not applicable1 country
- Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial MelasmaNot yet recruitingNCT07881328Phase 41 country
- Efficacy Evaluation of a Cosmetic Product for Facial HyperpigmentationRecruitingNCT07769268Not applicable1 country
- Topical Metformin Versus Triple Regimen for Epidermal MelasmaNot yet recruitingNCT07779811Phase 21 country
- Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in MelasmaNot yet recruitingNCT07732192Phase 4
- A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult ParticipantsRecruitingNCT07679945Not applicable1 country
- Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of MelasmaNot yet recruitingNCT07604844Not applicable1 country
- Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for MelasmaRecruitingNCT07540702Not applicable1 country
- Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of MelasmaNot yet recruitingNCT07530016Not applicable
- Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of MelasmaNot yet recruitingNCT07522788Phase 4
- Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in MelasmaNot yet recruitingNCT07495748Not applicable1 country
- Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With MelasmaNot yet recruitingNCT07485777Not applicable1 country
- Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of MelasmaNot yet recruitingNCT07448415Phase 2/3
- Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation ConditionsNot yet recruitingNCT07429786Not applicable
- Expert Consensus on the Clinical Management of Melasma: A Delphi Method StudyEnrolling by invitationNCT072965491 country
- Ultrasound-Enhanced Delivery of Compound TXA Solution in MelasmaRecruitingNCT07202156Not applicable1 country
- Oral Melatonin Versus Oral Tranexamic Acid in the Management of MelasmaEnrolling by invitationNCT07169383Phase 21 country
- Secretome TGF Beta 3Not yet recruitingNCT07137130Not applicable1 country
- COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYSRecruitingNCT07071363Not applicable1 country
- Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPESNot yet recruitingNCT07121439Not applicable1 country
- Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face StudyNot yet recruitingNCT07060157Not applicable1 country
- Topical Metformin Versus Topical Ketotifen in Melasma TreatmentNot yet recruitingNCT06942390Phase 2
- Oral Metformin for Treating Melasma in Latin American WomenRecruitingNCT06845540Phase 1/21 country
- Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in the Treatment of MelasmaNot yet recruitingNCT06780644Not applicable1 country
- Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic DermatosisNot yet recruitingNCT06763367Not applicable1 country
- Randomized Study Using SM-030 Gel for Adults With MelasmaRecruitingNCT06454747Phase 21 country
- The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic DermatitisRecruitingNCT05942248Not applicable1 country
- Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 OriginsRecruitingNCT06253468Not applicable1 country
- Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic AcidRecruitingNCT06522984Not applicable1 country
- Development of Products Based on Secretom From Stem Cell Conditioned Medium for Melasma TherapyRecruitingNCT06516419Not applicable1 country
- Anti-pigmenting Effect of a Routine of Facial Products in Subjects With MelasmaNot yet recruitingNCT06516224Not applicable1 country
- Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 OriginsRecruitingNCT06268496Not applicable1 country
- Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of MelasmaRecruitingNCT06418568Not applicable1 country
- Sylfirm X Radiofrequency Microneedling for the Treatment of MelasmaRecruitingNCT06415435Not applicable1 country
- Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 OriginsRecruitingNCT06320314Not applicable1 country
- Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal MelasmaRecruitingNCT06278948Not applicable1 country
- Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 OriginsNot yet recruitingNCT06234527Not applicable1 country
- Oral Isotretinoin in Melasma a Randomized Controlled TrialRecruitingNCT06201624Phase 11 country
- Effectiveness and Safety of Pigment Solution Program (PSP) as Adjuvant Therapy in MelasmaRecruitingNCT06174545Not applicable1 country
- Curcuma Xanthorriza Roxb. 10% Cream for MelasmaRecruitingNCT06153134Early Phase 11 country
- Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma.Not yet recruitingNCT05911698Not applicable
- Comparative Evaluation of Microsurgery vs Conventional Surgical Technique of Gingival DepigmentationNot yet recruitingNCT05930392Not applicable1 country
- Comparative Evaluation of Microsurgery vs Diode Laser Technique of Gingival DepigmentationNot yet recruitingNCT05930366Not applicable1 country
- Tranexamic Acid With Microneedling in MelasmaNot yet recruitingNCT05909072Phase 2
- To Evaluate the Effectiveness of Topical Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% as Compared to Topical Tretinoin 0.05% + Hydroquinone 4% + Fluocinolone 0.01% for the Treatment of MelasmaCompletedNCT07876323Phase 21 country
- Efficacy and Safety of Triple-Combination Cream Plus Microneedling Along With Tranexamic Acid Versus Platelet-Rich Plasma in the Treatment of Moderate-to-Severe Melasma: A Randomized Comparative StudyActive, not recruitingNCT07893067Phase 41 country
- Treatment and Prevention of Melasma Relapses by Using 1064nm 650 Microsecond LaserActive, not recruitingNCT06644157Not applicable1 country
- Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous PenetrationCompletedNCT06221787Not applicable1 country