Hyperpigmentation clinical trials

The registry lists 102 studies for Hyperpigmentation across more than 10 countries. 19 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-16.

Studies

Recruiting first, then most recently updated. Showing 50 of 102 — search for more.

• Efficacy Evaluation of a Cosmetic Product for Facial HyperpigmentationRecruitingNCT07769268Not applicable1 country
• Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of ColorRecruitingNCT05362929Not applicable1 country
• A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult ParticipantsRecruitingNCT07679945Not applicable1 country
• Study on the Functional Impact of Cosmetics on Improving Self-Esteem and Quality of Life in Black WomenRecruitingNCT07618572Not applicable1 country
• Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of MelasmaNot yet recruitingNCT07604844Not applicable1 country
• Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation ConditionsNot yet recruitingNCT07429786Not applicable
• Clinical Study to Assess Safety, Effectiveness and In-Use Tolerability of Saffron Extract Capsules for Improving Skin Health and Reducing Signs of Aging on Healthy Adult Male and Female Subjects.Not yet recruitingNCT07324759Not applicable
• An 18-week Study to Evaluate a Test Product With a Marketed Prescription ProductEnrolling by invitationNCT07136766Phase 31 country
• COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYSRecruitingNCT07071363Not applicable1 country
• The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip HyperpigmentationRecruitingNCT07067879Not applicable1 country
• Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 OriginsRecruitingNCT06253468Not applicable1 country
• Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 OriginsRecruitingNCT06268496Not applicable1 country
• Evaluation of the Tolerance (Main Objective) and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) on the FaceNot yet recruitingNCT06305897Not applicable
• Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 OriginsRecruitingNCT06320314Not applicable1 country
• Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 OriginsNot yet recruitingNCT06234527Not applicable1 country
• Efficacy and Safety Assessment of Niacinamide Cosmetic Preparation: a Randomized Controlled TrialRecruitingNCT06189105Not applicable1 country
• Comparison Of Aesthetic Techniques For Rejuvenation Of Genital Region: A Randomized Clinical TrialRecruitingNCT04998578Not applicable1 country
• Performance and Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in th Treatment of Brown Spots (Solar and Senile Lentigines, Post-Inflammatory Hyperpigmentation) on the Face and Hands of Asian Ethnicity SkinsNot yet recruitingNCT05886010Not applicable1 country
• Partial Breast Versus no Irradiation for Women With Early Breast CancerRecruitingNCT03646955Not applicable4 countries
• Apple Peptide Complex for Post-Surgical and Aesthetic Skin RecoveryCompletedNCT07807085Not applicable1 country
• Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and TelangiectasiasActive, not recruitingNCT07793630Phase 41 country
• Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Oziva Bioactive Gluta Fizzy Effervescent Tablets on Subjects With Facial Dark Spots Such as Pimple Marks, Sunspots, Age Spots and Uneven Skin ToneCompletedNCT07162623Not applicable1 country
• Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With MelasmaCompletedNCT07727954Not applicable1 country
• Clinical Efficacy and Safety of MB LuxuryⓇ Product Containing Epigallocathecin Gallate (EGCG) on Erythema, Melanin, and Skin HydrationCompletedNCT07725900Phase 2/31 country
• Homocysteic Acid Biostimulator for Photoaged Facial SkinCompletedNCT07722351Not applicable1 country
• A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face HyperpigmentationCompletedNCT07644871Not applicable1 country
• Evaluation of the Safety and Tolerability of a Brightening Treatment Paired With a Skincare RegimenCompletedNCT07501000Not applicable1 country
• Efficacy of Cosmetic Products in Preventing Pigmentation Induced by High Energy Visible Light (HEVL) [400-450nm]CompletedNCT075375951 country
• A 16-week Clinical Study Investigating a Dark Spot Corrector Serum in Women With Moderate Discrete HyperpigmentationCompletedNCT07468175Not applicable1 country
• Safety and Efficacy of Topical Cream for Post-inflammatory Hyperpigmentation Skin Among MalaysiansCompletedNCT05986123Not applicable1 country
• Safety of Serum for Post-Inflammatory on Hyperpigmentation SkinCompletedNCT05998200Not applicable1 country
• Azelaic Acid 20% vs Hydroquinone 4% in Epidermal MelasmaCompletedNCT07327983Not applicable1 country
• Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VICompletedNCT05493280Not applicable1 country
• Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial HyperpigmentationActive, not recruitingNCT07263841Phase 21 country
• Efficacy of the SALFOAM 3% Method Compared to the Conventional Polidocanol Foam Method (Tessari Method) for Treating Lower Limb Varicose VeinsCompletedNCT06667570Not applicable1 country
• A Novel Regimen for Treatment and Prevention of Post-Inflammatory Hyperpigmentation in Skin of ColorCompletedNCT06938815Not applicable1 country
• Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of HyperpigmentationCompletedNCT07133204Not applicable1 country
• Effectiveness of Omega-3 Poly Unsaturated Fatty Acids on The Treatment of Gingival HyperpigmentationActive, not recruitingNCT07067515Phase 1/21 country
• Annurca Apple Peel Oleolite for the Treatment of Skin HyperpigmentationCompletedNCT07040345Not applicable1 country
• Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of MelasmaActive, not recruitingNCT07034560Phase 41 country
• Melanin Recurrence in Scalpel and LASER Gingival Depigmentation in Thin and Thick Phenotypes.CompletedNCT06886100Not applicable1 country
• Brightening Cream and Lasers in Post-sclerotherapy HyperpigmentationCompletedNCT05165524Not applicable1 country
• Evaluation of Effects on Skin Quality of a Centella Asiatica Extracellular Vesicle-based Skin Care Formulation.CompletedNCT06850935Not applicable1 country
• The Efficacy of Bakuchiol in Treating PIHCompletedNCT06833996Not applicable1 country
• Clinical Efficacy of the Product in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP) SubjectsCompletedNCT068223351 country
• Efficacy of La Roche Posay Routine in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP)CompletedNCT067701271 country
• Open-label, Single-arm, Proof of Concept Study in Subjects with Mild-to-moderate Facial HyperpigmentationWithdrawnNCT06473974Phase 21 country
• The Effects of Cetyl Tranexamate Mesylate on the Appearance of Acne-Related HyperpigmentationCompletedNCT06080035Not applicable1 country
• Incidence of Hyperpigmentation in Black Patients With Multiple Myeloma Treated With Immunomodulatory DrugsCompletedNCT061601671 country
• The Efficacy Tretinoin Cream in the Treatment of Axillary Hyperpigmentation Associated With Acanthosis NigricansCompletedNCT06213987Phase 31 country