Drug
Tretinoin clinical trials
Also written ATRA, Vesanoid, Retin-A and Ro 5488.
Includes 2 studies of Tretinoin Liposome.
- studies test it
- 143
- open now
- 25
- in phase 3
- 27
- first study started
- 1991
Keep track of what changes. Save the Tretinoin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Other names
- ATRA
- 41
Studies by the year they started
143 studies that test it; most in 2025 (11)
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1993 | 2 |
| 1995 | 1 |
| 1996 | 1 |
| 1997 | 1 |
| 1998 | 1 |
| 1999 | 5 |
| 2000 | 2 |
| 2004 | 6 |
| 2005 | 2 |
| 2006 | 2 |
| 2007 | 9 |
| 2008 | 7 |
| 2009 | 10 |
| 2010 | 6 |
| 2011 | 7 |
| 2012 | 4 |
| 2013 | 4 |
| 2014 | 2 |
| 2015 | 7 |
| 2016 | 3 |
| 2017 | 6 |
| 2018 | 4 |
| 2019 | 6 |
| 2020 | 7 |
| 2021 | 5 |
| 2022 | 3 |
| 2023 | 2 |
| 2024 | 10 |
| 2025 | 11 |
| 2026 | 6 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 10
- Phase 1
- 32
- Phase 2
- 76
- Phase 3
- 27
- Phase 4
- 14
- No phase
- 8
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 22 · Other 121
Peking University People's Hospital (7) · Bausch Health Americas, Inc. (5) · Gruppo Italiano Malattie EMatologiche dell'Adulto (4) · M.D. Anderson Cancer Center (4) · Johns Hopkins University (3) · Memorial Sloan Kettering Cancer Center (3) · Taro Pharmaceuticals USA (3) · Spear Pharmaceuticals (3)
Often tested with
Tested in the same studies.
Arsenic Trioxide (10) · Azacitidine (6) · Adapalene (5) · Valproic Acid (5) · Pembrolizumab (4) · Venetoclax (3) · Benzoyl Peroxide (3) · Tranylcypromine (3)
Studies
Open first, then newest update. How each study uses Tretinoin is read from its arms, and is right about nine times in ten.
Testing it · 143
- Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic LeukemiaRecruitingPhase 3Quetzal TherapeuticsNCT07504458Written as QTX-2101 + ATRA
- Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced LeiomyosarcomaRecruitingPhase 2Gabriel TinocoNCT06528769Written as all-trans retinoic acid
- Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of EpendymomaNot yet recruitingPhase 1/2Children's Oncology GroupNCT07848568Written as Tretinoin
- Phase 1 Study of ATRA Plus a PD-1 Inhibitor in EGFR-Mutant NSCLC After Third-Generation EGFR-TKI ResistanceNot yet recruitingPhase 1Cancer Institute and Hospital, Chinese Academy of Medical SciencesNCT07842887Written as All-trans retinoic acid
- All-Trans Retinoic Acid for the Treatment of Hemophagocytic LymphohistiocytosisNot yet recruitingPhase 2/3Beijing Anzhen HospitalNCT07626398Written as ATRA
- Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic LeukemiaRecruitingPhase 2M.D. Anderson Cancer CenterNCT01409161Written as Tretinoin
- ATRA for Management of Primary ITPNot yet recruitingPhase 3Peking University People's HospitalNCT07597395Written as all-trans retinoic acid (ATRA)
- Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gastrointestinal Solid TumorsRecruitingPhase 2Peking University People's HospitalNCT07586813Written as All-trans retinoic acid
- Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gynecologic, Breast, or Lung Solid TumorsRecruitingPhase 2Peking University People's HospitalNCT07586826Written as All-trans retinoic acid
- Lymphocyte-Sparing And Radio-Immunotherapy in Head and Neck CarcinomaRecruitingPhase 3Centre Leon BerardNCT06706401Written as Vesanoid
- ATRA and Carfilzomib in Plasma Cell Myeloma PatientsRecruitingPhase 1/2The Methodist Hospital Research InstituteNCT06536413Written as All-Trans Retinoic Acid (ATRA) Dose 0
- All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant GliomaRecruitingPhase 2Stephen Bagley, MD, MSCENCT05345002Written as All-trans retinoic acid
- Topical Tretinoin Prophylaxis for Anti-EGFR Induced Skin Toxicity in Patients With Solid TumorsRecruitingPhase 2University of UtahNCT06358677Written as Topical Tretinoin
- A Phase II Study of the Combination of Pembrolizumab and ATRA Combination Treatment of Relapsed HL and B-NHLRecruitingPhase 2Rita AssiNCT06484920Written as ATRA
- ATRA and SDK002 in Combination With Chemotherapy and Anti-PD-1 Inhibitor in Patients With Advanced Pancreatic Ductal Adenocarcinoma.Not yet recruitingPhase 1Daniel BreadnerNCT07348107Written as ATRA
- Avatrombopag Combined With All-trans Retinoic Acid in the Treatment of Primary Immune ThrombocytopeniaNot yet recruitingPhase 2/3Institute of Hematology & Blood Diseases Hospital, ChinaNCT07278908Written as Avatrombopag+All trans retinoic acid
- Lymphocyte Support to SBRT in Patients With Oligo-metastatic Solid CancerRecruitingPhase 1/2Gustave Roussy, Cancer Campus, Grand ParisNCT06439888Written as all-trans retinoic acid
- Reverse HER2-negative Immune Resistant Breast CancerRecruitingPhase 2Fudan UniversityNCT06731140Written as Retinoic Acid
- Investigating the Therapeutic Efficacy of All-trans Retinoic Acid in Autism Spectrum Disorder Patients With 15q11-13 Duplication SyndromeNot yet recruitingPhase 2Second Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT07079696Written as ATRA
- Efficacy and Safety of ATO Plus ATRA in Nucleophosmin-1 Mutated Acute Myeloid LeukemiaEnrolling by invitationPhase 1/2Institute of Hematology & Blood Diseases Hospital, ChinaNCT03031249Written as all-trans retinoic acid
See all 143 studies that test Tretinoin →
Given in every arm · 26 — Tretinoin is usual care beside what is tested
- Early Use of Realgar-Indigo Naturalis Formula (RIF) Combined With All-trans Retinoic Acid (ATRA) for Treating Acute Promyelocytic Leukemia (APL).RecruitingPhase 3First Affiliated Hospital Xi'an Jiaotong UniversityNCT07503730Written as ATRA
- A Trial to Investigate Whether Oral Arsenic Trioxide Is Similar to Intravenous Arsenic Trioxide in Pharmacokinetics, Safety, and Efficacy (LATITUDE/SDKARS-301)Not yet recruitingPhase 3SDK Therapeutics, Inc.NCT07296445Written as all-trans retinoic acid (ATRA)
- A Study on the Efficacy and Safety of Oral All-trans Retinoic Acid Combined With Toripalimab in TNBC.RecruitingNot applicableFirst Affiliated Hospital of Zhejiang UniversityNCT06371274Written as ATRA
- Treatment Study for Children and Adolescents With Acute Promyelocytic LeukemiaRecruitingPhase 2Associazione Italiana Ematologia Oncologia PediatricaNCT04793919Written as All-trans retinoic acid
- Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)CompletedPhase 1/2Merck Sharp & Dohme LLCNCT04305041Written as ATRA
- Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)CompletedPhase 1/2Merck Sharp & Dohme LLCNCT04303169Written as ATRA
- Sirolimus Combined With ATRA for the Treatment of Auto-Immune AnemiaWithdrawnPhase 4Peking Union Medical College HospitalNCT04324411Written as sirolimus and ATRA
- Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic LeukemiaCompletedPhase 3Technische Universität DresdenNCT02688140Written as Tretinoin
- Evaluation of ATRA Activity in Combination With Anastrozole in Pre-operative Phase of Operable Early Breast CancerTerminatedPhase 2Mario Negri Institute for Pharmacological ResearchNCT04113863Written as all-trans retinoic acid
- An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced MalignanciesTerminatedPhase 1/2Incyte CorporationNCT02712905Written as all-trans retinoic acid (ATRA)
- The Combination of ATRA and Eltrombopag as the Treatment of Steroid-resistant/Relapse ITP Based on MSC-C5b-9CompletedPhase 3Peking University People's HospitalNCT05438875Written as all-trans retinoic acid
- A Study of Daratumumab With Pomalidomide, Dexamethasone, and All-Transretinoic Acid in Patients With Multiple MyelomaTerminatedPhase 2Hackensack Meridian HealthNCT04700176Written as All-trans retinoic acid
- Ipilimumab and All-Trans Retinoic Acid Combination Treatment of Advanced MelanomaCompletedPhase 2University of Colorado, DenverNCT02403778Written as VESANOID
- S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic LeukemiaCompletedPhase 2SWOG Cancer Research NetworkNCT00551460Written as tretinoin
- NB2013-HR German (GPOH) / Dutch (DCOG) TrialTerminatedPhase 2University of CologneNCT02641782Written as Retinoic acid
- Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic LeukemiaCompletedPhase 3Children's Oncology GroupNCT00866918Written as Tretinoin
- A Study for Improving the Outcome of Childhood Acute Promyeloid LeukemiaCompletedPhase 4South China Children's Leukemia GroupNCT02200978Written as ATRA
- Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)Status unknownPhase 3First Affiliated Hospital Xi'an Jiaotong UniversityNCT02899169Written as all-trans retinoic acid
- Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer.Status unknownPhase 3Mahmoud Ramadan mohamed ElkazzazNCT05016349Written as All trans-retinoic acid
- A Phase I Dose Escalation Study of GSK2879552 in Subjects With Acute Myeloid Leukemia (AML)TerminatedPhase 1GlaxoSmithKlineNCT02177812Written as ATRA
Showing 20 of 26.
As the comparator · 10 — what is tested is compared with Tretinoin
- Topical Application of Engineered Lactobacillus Reuteri With a Zinc Sulfate-Tannic Acid MPN Coating for AcneRecruitingPhase 2Shenzhen People's HospitalNCT07366229Written as Tretinoin cream 0.1%
- A Study Comparing Tretinoin Gel Microsphere, 0.04% and RETIN-A MICRO ® Gel Microsphere, 0.04% in the Treatment of Acne VulgarisCompletedPhase 1Sun Pharmaceutical Industries, Inc.NCT07469228Written as RETIN-A MICRO® (Tretinoin) Gel Microsphere, 0.04%
- Treatment of Striae Distensae With Fractional Radiofrequency and Topical TretinoinCompletedPhase 2Merete HaedersdalNCT05461755Written as Topical Tretinoin
- Retinyl Palmitate-loaded Ethosomes in Acne VulgarisCompletedPhase 2Assiut UniversityNCT04080869Written as Tretinoin
- A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne VulgarisCompletedEarly Phase 1Taro Pharmaceuticals USANCT04883736Written as RETIN-A MICRO® (Tretinoin) Gel Microsphere, 0.1%
- MUSE Study to Evaluate the Pharmacokinetics, Safety and Tolerability of S6G5T-3CompletedPhase 1Sol-Gel Technologies, Ltd.NCT04059523Written as Retin-A® 0.1% Cream
- Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne VulgarisCompletedPhase 4Wake Forest UniversityNCT01047189Written as tretinoin 0.025% cream
- A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT GelCompletedPhase 3Stiefel, a GSK CompanyNCT00689117Written as Tretinoin Gel (tretinoin)
- Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of AgingCompletedNot applicableCosmetique Active InternationalNCT00974480Written as Tretinoin (Rejuva-A)
- Comparison of Two Treatments in Intermediate and High-risk Acute Promyelocytic Leukemia (APL) Patients to Assess Efficacy in 1st Hematological Complete Remission and Molecular RemissionCompletedPhase 3Wyeth is now a wholly owned subsidiary of PfizerNCT00962767Written as ATRA plus 6-MP and MTX
Codes
What other systems call Tretinoin · ClinicalTrials.gg INT008346
- MeSH (NLM) D014212TretinoinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 5688UTC01RTRETINOINConfirmed FDA, NLM, Wikidata
- RxNorm 10753Confirmed FDA, Wikidata
- Wikidata Q29417tretinoinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C900TretinoinOne source FDA
- DrugBank DB00755One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D014212 | Tretinoin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 5688UTC01R | TRETINOIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 10753 | — | Confirmed FDA, Wikidata |
| Wikidata | Q29417 | tretinoin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C900 | Tretinoin | One source FDA |
| DrugBank | DB00755 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.