Melanosis: all 159 studies

Page 1 of 2. Open to participants first (42), then studies with results posted, then the rest; newest registration first within each.

• COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMANot yet recruitingNCT07890571Not applicable
• New Treatment in MelasmaNot yet recruitingNCT07887399Not applicable
• Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial MelasmaNot yet recruitingNCT07881328Phase 4
• Topical Metformin Versus Triple Regimen for Epidermal MelasmaNot yet recruitingNCT07779811Phase 2
• Efficacy Evaluation of a Cosmetic Product for Facial HyperpigmentationRecruitingNCT07769268Not applicable
• Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in MelasmaNot yet recruitingNCT07732192Phase 4
• Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for MelasmaEnrolling by invitationNCT07696806Phase 4
• A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult ParticipantsRecruitingNCT07679945Not applicable
• Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of MelasmaNot yet recruitingNCT07604844Not applicable
• Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for MelasmaRecruitingNCT07540702Not applicable
• Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of MelasmaNot yet recruitingNCT07530016Not applicable
• Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of MelasmaNot yet recruitingNCT07522788Phase 4
• Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in MelasmaNot yet recruitingNCT07495748Not applicable
• Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With MelasmaNot yet recruitingNCT07485777Not applicable
• Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of MelasmaNot yet recruitingNCT07448415Phase 2/3
• Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation ConditionsNot yet recruitingNCT07429786Not applicable
• Expert Consensus on the Clinical Management of Melasma: A Delphi Method StudyEnrolling by invitationNCT07296549
• Ultrasound-Enhanced Delivery of Compound TXA Solution in MelasmaRecruitingNCT07202156Not applicable
• Oral Melatonin Versus Oral Tranexamic Acid in the Management of MelasmaEnrolling by invitationNCT07169383Phase 2
• Secretome TGF Beta 3Not yet recruitingNCT07137130Not applicable
• Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPESNot yet recruitingNCT07121439Not applicable
• COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYSRecruitingNCT07071363Not applicable
• Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face StudyNot yet recruitingNCT07060157Not applicable
• Topical Metformin Versus Topical Ketotifen in Melasma TreatmentNot yet recruitingNCT06942390Phase 2
• Oral Metformin for Treating Melasma in Latin American WomenRecruitingNCT06845540Phase 1/2
• Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in the Treatment of MelasmaNot yet recruitingNCT06780644Not applicable
• Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic AcidRecruitingNCT06522984Not applicable
• Development of Products Based on Secretom From Stem Cell Conditioned Medium for Melasma TherapyRecruitingNCT06516419Not applicable
• Anti-pigmenting Effect of a Routine of Facial Products in Subjects With MelasmaNot yet recruitingNCT06516224Not applicable
• A Cryotherapy With Tranexamic Acid Versus Normal Saline in the Treatment of MelasmaNot yet recruitingNCT06491771Not applicable
• Randomized Study Using SM-030 Gel for Adults With MelasmaRecruitingNCT06454747Phase 2
• Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of MelasmaRecruitingNCT06418568Not applicable
• Sylfirm X Radiofrequency Microneedling for the Treatment of MelasmaRecruitingNCT06415435Not applicable
• Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal MelasmaRecruitingNCT06278948Not applicable
• Oral Isotretinoin in Melasma a Randomized Controlled TrialRecruitingNCT06201624Phase 1
• Effectiveness and Safety of Pigment Solution Program (PSP) as Adjuvant Therapy in MelasmaRecruitingNCT06174545Not applicable
• Curcuma Xanthorriza Roxb. 10% Cream for MelasmaRecruitingNCT06153134Early Phase 1
• The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic DermatitisRecruitingNCT05942248Not applicable
• Comparative Evaluation of Microsurgery vs Conventional Surgical Technique of Gingival DepigmentationNot yet recruitingNCT05930392Not applicable
• Comparative Evaluation of Microsurgery vs Diode Laser Technique of Gingival DepigmentationNot yet recruitingNCT05930366Not applicable
• Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma.Not yet recruitingNCT05911698Not applicable
• Tranexamic Acid With Microneedling in MelasmaNot yet recruitingNCT05909072Phase 2
• Lutronic PicoPlus Exploratory Clinical TrialTerminatedNCT03415685Not applicableResults posted
• Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With Moderate Facial MelasmaCompletedNCT02977507Not applicableResults posted
• Topical Composition Therapy (2013-MCN-333) for the Treatment of MelasmaCompletedNCT02730819Phase 2Results posted
• A Pilot Study Testing 1064nm Q-switch Laser Versus Glycolic Acid Peels for the Treatment of MelasmaCompletedNCT01976273Not applicableResults posted
• Study of Laser Treatment of MelasmaCompletedNCT01335581Not applicableResults posted
• Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in MelasmaTerminatedNCT00669071Phase 4Results posted
• Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic WomenCompletedNCT00616239Phase 4Results posted
• Efficacy and Safety of Triple-Combination Cream Plus Microneedling Along With Tranexamic Acid Versus Platelet-Rich Plasma in the Treatment of Moderate-to-Severe Melasma: A Randomized Comparative StudyActive, not recruitingNCT07893067Phase 4
• Randomized Split-Face Controlled Study to Evaluate the Effectiveness of Topical Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% as Compared to Topical Tretinoin 0.05% + Hydroquinone 4% + Fluocinolone 0.01% for the Treatment of MelasmaCompletedNCT07876323Phase 2
• Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With MelasmaCompletedNCT07727954Not applicable
• Homocysteic Acid Biostimulator for Photoaged Facial SkinCompletedNCT07722351Not applicable
• Efficacy of New Trio Combination for MelasmaCompletedNCT07676994Phase 4
• Microfocused Ultrasound for Facial Pigmentary Diseases and RosaceaActive, not recruitingNCT07667972Not applicable
• A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face HyperpigmentationCompletedNCT07644871Not applicable
• Comparison of Efficacy of Topical Westerhoff Formula Cream Vs Topical 4% Hydroquinone for the Treatment of MelasmaCompletedNCT07508098Phase 4
• A Novel 532-nm Picosecond Laser for Freckle Treatment in Chinese PatientsCompletedNCT07352631Not applicable
• Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital KarachiCompletedNCT07345507Not applicable
• Azelaic Acid 20% vs Hydroquinone 4% in Epidermal MelasmaCompletedNCT07327983Not applicable
• Comparison of Intradermal Microinjections of Tanexamic Acid and Oral Tranexamic Acid in the Management of Melasma.CompletedNCT07280234Early Phase 1
• Efficacy and Safety of 30% Salicylic Acid and 10% Nicotinamide Combined Therapy in MelasmaCompletedNCT07062120Not applicable
• Annurca Apple Peel Oleolite for the Treatment of Skin HyperpigmentationCompletedNCT07040345Not applicable
• Comparative Effects Of Trichloroacetic Chemical Peel And Fractional LaserActive, not recruitingNCT07036302Not applicable
• Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of MelasmaActive, not recruitingNCT07034560Phase 4
• Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled StudyCompletedNCT06957834Phase 2
• EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMACompletedNCT06787846Not applicable
• Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of MelasmaCompletedNCT06677931Not applicable
• Treatment and Prevention of Melasma Relapses by Using 1064nm 650 Microsecond LaserActive, not recruitingNCT06644157Not applicable
• Efficacy of Radiofrequency Micro Needling for the Treatment of Melasma in Skin of Color.CompletedNCT06616311Not applicable
• The Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R AntagonistCompletedNCT06313307Not applicable
• Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous PenetrationCompletedNCT06221787Not applicable
• Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma.Active, not recruitingNCT06013540Phase 2
• The Effectiveness of 3% Topical Tranexamic Acid Compared to 4% Topical Hydroquinone as Therapy of MelasmaActive, not recruitingNCT06010810Phase 3
• Cysteamine Compared to Hydroquinone in MelasmaCompletedNCT05969587Phase 3
• Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in MelasmaCompletedNCT05887219Phase 1
• Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of MelasmaCompletedNCT05884151Phase 1
• A Study to Assess Effect of Two Facial Sunscreens in Improving Wrinkles, Fine Lines and Melasma in Adult ParticipantsCompletedNCT05864417Not applicable
• Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of MelasmaCompletedNCT05790577Phase 2
• Tissue-resident Memory T Cells Expression in MelasmaCompletedNCT05698342
• Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial MelasmaStatus unknownNCT05656833Not applicable
• Efficacy of Intralesional PRP +/- Topical Silymarin in the Treatment of MelasmaStatus unknownNCT05626881Not applicable
• Comparison of Chemical Peeling Agent With Transamine for Treatment of MelasmaCompletedNCT05362500Phase 1
• Treatment of Melasma With Yellow Light Compared to Tranexamic AcidTerminatedNCT05326997Not applicable
• Effectiveness and Safety of Intradermal Tranexamic Acid Injection as An Adjunctive Treatment for Melasma in Skin Type IV - VCompletedNCT05236569Not applicable
• Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of MelasmaCompletedNCT05119413Phase 2
• Silymarin Cream Versus Combined Silymarin Cream and Microneedling in Treatment of MelasmaStatus unknownNCT05099601Phase 4
• Green Banana Peel Extract for Melasma TreatmentCompletedNCT05031689Phase 1
• A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate MelasmaCompletedNCT05013801Not applicable
• OneDoc Picopulse™ for the Treatment of Melasma Among Malaysian WomenCompletedNCT04834167Not applicable
• Trichloroacetic Acid (TCA) Combined With Microdermabrasion in Treatment of MelasmaStatus unknownNCT04823520Phase 4
• Combined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in MelasmaStatus unknownNCT04765930Not applicable
• Photoaging Reversing After Picosecond Laser With DLA Assessed by Cellular Resolution OCT in Asian Patient With MelasmaCompletedNCT04602819Not applicable
• Evaluation of Laser and Tranexamic Acid in Treatment of MelasmaStatus unknownNCT04599205Phase 2/3
• Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared With 2% Hydroquinone Alone for the Treatment of Melasma: a Randomized Split-face Controlled TrialStatus unknownNCT04597203Not applicable
• Opsin Receptors in MelasmaCompletedNCT04417348Not applicable
• Comparison Between Free Thyroxine and Thyroid Stimulating Hormone Levels on Melasma SeverityCompletedNCT04359719
• Atypical MOLes and Melanoma Early Detection Study (MoleMed)Status unknownNCT04353050Not applicable
• Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With MelasmaCompletedNCT04346901Phase 1
• Efficacy of Red Light in the Treatment of Pigmentary DisordersStatus unknownNCT04308421Not applicable

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