ClinicalTrials.gg
TerminatedNCT05509088Updated Oct 30, 2026

Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical Trial

An interventional study of high flow nasal cannula in Traumatic Lung Injury, sponsored by Ain Shams University. Terminated at 1 site in Egypt. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-30.

Sponsored by Ain Shams University · Not applicable, Interventional, and Prevention

Why this study was terminated
not able to het the target subject number
Updated Oct 30, 2026Now TerminatedPrimary completion moved+3 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Early and continuous administration of oxygen via high flow nasal cannula in patients with lung contusion and non-severe acute lung injury might reduce the incidence of intubation and hold the deterioration of pulmonary functions.

02

Conditions studied

  • Traumatic Lung Injury

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03

In context

Lung Injury

114 studies on the registry are indexed under Lung Injury; 33 are open to participants now.

This study's enrollment of 120 is above the median of 62 across 75 interventional studies indexed under Lung Injury.

Browse Lung Injury studies →

Lead sponsor

Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.

Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

The criteria were revised on the registry on Oct 30, 2026. See what changed

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Willing and able to provide written prior to performing study procedures,
  • currently hospitalized and requiring medical care for blunt chest trauma, within 24h of trauma
  • chest computed tomography (CT) scan confirming the presence of lung contusion.
  • Hypoxemia, indicated by a PaO2/FiO2 ratio of 100 and 200 while breathing oxygen at an FGF rate of 10 L/min via an oxygen mask, or oxygen saturation (SpO2) \< 90% while on 10 L/min of oxygen, with a PaCO2 ≤ 45 mm Hg.

Exclusion criteria

Exclusion Criteria:

  • face trauma or surgery, airway obstruction, known to have chronic chest condition
  • hemodynamic instability.
  • Impaired consciousness, the need for emergency surgery, or the presence of a flail chest.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
120 participants (actual)

Study arms

  • Experimental
    high flow nasal cannula

    will receive oxygen through high flow nasal cannula

    Device: high flow nasal cannula

  • No intervention
    oxygen mask

    will receive oxygen through oxygen mask

Interventions

  • Devicehigh flow nasal cannula

    Patients in the intervention group receive oxygen through HFNC with a flow rate of set initially at 40 L / min, FiO2 adjusted to maintain SpO2 ≥ 92%, and will be humidified, heated to 34-37 °C, disconnection will be allowed only when ambulation is required, patients will be instructed to practice mouth closing throughout the HFNC therapy as much as possible

06

What researchers measure

Primary outcomes

  1. need for intubation and mechanical ventilation within 28 days of randomization.

    the incidence of intubation in patients with lung contusion who receive oxygen through high flow nasal cannula

    Time frame: 3 months

07

Study locations

1 site
  • Ain Shams University hospitals
    Cairo, 11591, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Status
Status unknown→Terminated not able to het the target subject number
changed Oct 30, 2026
Primary completion
Dec 28, 2022→Dec 28, 2024 (actual)
Oct 30, 2026
Study completion
Dec 28, 2022→Dec 28, 2024 (actual)
Oct 30, 2026
Eligibility
1 inclusion criterion edited, 3 added; 2 exclusion criteria added
What changed in the criteria
Inclusion criteria
  • AddedWilling and able to provide written informed consent prior to performing study procedures,
  • EditedWilling and able to provide written informed consent prior to performing study procedures, currently hospitalized and requiring medical care for blunt chest trauma, within 24h of trauma
  • Addedchest computed tomography (CT) scan confirming the presence of lung contusion.
  • AddedHypoxemia, indicated by a PaO2/FiO2 ratio of 100 and 200 while breathing oxygen at an FGF rate of 10 L/min via an oxygen mask, or oxygen saturation (SpO2) < 90% while on 10 L/min of oxygen, with a PaCO2 ≤ 45 mm Hg.
Exclusion criteria
  • Addedhemodynamic instability.
  • AddedImpaired consciousness, the need for emergency surgery, or the presence of a flail chest.
Oct 30, 2026
Show all 1 update
  1. Oct 30, 2026
    Status unknown→Terminated
    Why stopped not able to het the target subject number
    Primary completion Dec 28, 2022→Dec 28, 2024 (now actual)
    Study completion Dec 28, 2022→Dec 28, 2024 (now actual)
    Eligibility 1 inclusion criterion edited, 3 added; 2 exclusion criteria added
    What changed in the criteria
    Inclusion criteria
    • AddedWilling and able to provide written informed consent prior to performing study procedures,
    • EditedWilling and able to provide written informed consent prior to performing study procedures, currently hospitalized and requiring medical care for blunt chest trauma, within 24h of trauma
    • Addedchest computed tomography (CT) scan confirming the presence of lung contusion.
    • AddedHypoxemia, indicated by a PaO2/FiO2 ratio of 100 and 200 while breathing oxygen at an FGF rate of 10 L/min via an oxygen mask, or oxygen saturation (SpO2) < 90% while on 10 L/min of oxygen, with a PaCO2 ≤ 45 mm Hg.
    Exclusion criteria
    • Addedhemodynamic instability.
    • AddedImpaired consciousness, the need for emergency surgery, or the presence of a flail chest.
    + 4 other changes: index terms, description, contact details and site details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT05509088
Responsible party
Sponsor
First posted
Aug 19, 2022
Start date
Jul 28, 2022
Primary completion
Dec 28, 2024
Completion
Dec 28, 2024
Last update
Oct 30, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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