Ventilator-Induced Lung Injury clinical trials
The registry lists 121 studies for Ventilator-Induced Lung Injury across more than 10 countries. 39 are recruiting or about to start. 61 of them are mainly about Ventilator-Induced Lung Injury (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Bronchopulmonary Dysplasia too: 476 studies, 123 open.
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Who runs them
Centre hospitalier de l'Université de Montréal (CHUM) (4) · Başakşehir Çam & Sakura City Hospital (3) · Assistance Publique - Hôpitaux de Paris (3) · Canadian Critical Care Trials Group (3) · Unity Health Toronto (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · Lungpacer Medical Inc. (3) · University of California, San Diego (3)
What is being tested here
Drugs under test in Ventilator-Induced Lung Injury studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ascorbic Acid | 1 | 0 | 1 |
| Furosemide | 0 | 0 | 1 |
| Rocuronium | 0 | 0 | 1 |
| Midazolam | 0 | 0 | 1 |
| Propofol | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Electrical Impedance Tomography for Identification of Optimal Positive End-expiratory Pressure in Newborn Infants · University Children's Hospital Basel
- Dec 2026Open Lung Protective Extubation Following General Anesthesia · Centre hospitalier de l'Université de Montréal (CHUM)
- Dec 2026Phrenic Identification in the ICU · Unity Health Toronto
- Dec 2026Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study) · Peking Union Medical College Hospital
- Jan 2027Physiological Effects of Controlled vs. Assisted Ventilation During Moderate-to-severe ARDS (PEARL Study) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Jan 2027Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial · Capital Medical University
- Feb 2027Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury · Peninsula Health
- Apr 2027Ventilation of the Extremely Premature Infants Optimized by Dead Space Washout · Centre Hospitalier Intercommunal Creteil
- Apr 2027Development and Prospective Validation of the AutoEIT Foundation Model for ARDS · Ruijin Hospital
- May 2027Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients · Assiut University
Who these studies take
Of the 22 Ventilator-Induced Lung Injury studies recruiting now, 15 (68%) set no upper age limit and 5 (23%) stop at 75 or younger. 5 (23%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (14%) | 3 (14%) |
| 18 | 21 (95%) | 21 (95%) |
| 30 | 20 (91%) | 20 (91%) |
| 40 | 20 (91%) | 20 (91%) |
| 50 | 20 (91%) | 20 (91%) |
| 65 | 19 (86%) | 19 (86%) |
| 75 | 19 (86%) | 19 (86%) |
| 85 | 16 (73%) | 16 (73%) |
Across all 121 studies, recruiting or not: 23% stop at 75 or younger and 12% at 65; 18% take children; 0% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ventilator-Induced Lung Injury studies take
Of 40 interventional studies with no phase under Ventilator-Induced Lung Injury, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo13–54 · 40 studies | — | — |
| Observational | 27 mo12–… · 30 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Results posted1
Newly registered1
- Development and Prospective Validation of the AutoEIT Foundation Model for ARDSOct 27, 2026NCT07898319
Studies
Recruiting first, then most recently updated. Showing 50 of 121. Browse all 121 → or search them.
- Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDSNot yet recruitingNCT07790133Not applicable1 country
- Personalized Ventilator Settings for Patients on ECMOEnrolling by invitationNCT07673250Not applicable1 country
- Development and Prospective Validation of the AutoEIT Foundation Model for ARDSNot yet recruitingNCT078983191 country
- Mechanical Power and Mortality in Mechanically Ventilated AdultsNot yet recruitingNCT078361531 country
- Open Lung Protective Extubation Following General AnesthesiaRecruitingNCT06296173Not applicable1 country
- A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress SyndromeNot yet recruitingNCT07629973Not applicable
- Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.RecruitingNCT07603310Not applicable1 country
- Mechanical Power During Different Ventilation Modes in Laparoscopic SurgeryRecruitingNCT07670494Not applicable1 country
- Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDSRecruitingNCT07595926Not applicable1 country
- Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)RecruitingNCT07307066Not applicable1 country
- Electrical Impedance Tomography for Identification of Optimal Positive End-expiratory Pressure in Newborn InfantsRecruitingNCT056122561 country
- Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese PatientsNot yet recruitingNCT07542093
- Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision SupportRecruitingNCT056686375 countries
- Clinical Decision Support Tool in PARDS Pilot StudyRecruitingNCT04068012Not applicable3 countries
- Prevention of Postoperative Respiratory ComplicationsNot yet recruitingNCT068992951 country
- Physiological Effects of Controlled vs. Assisted Ventilation During Moderate-to-severe ARDS (PEARL Study)Not yet recruitingNCT07315815
- Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) TrialRecruitingNCT06526598Not applicable1 country
- A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICURecruitingNCT034057791 country
- Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVARecruitingNCT05689476Not applicable1 country
- Biphasic Positive Airway Pressure Ventilation Versus Flow-Controlled Ventilation in Burn PatientsNot yet recruitingNCT07041957Not applicable1 country
- Inspiratory Work of Breathing Before and After ExtubationRecruitingNCT070176081 country
- Electrical Impedance Tomography-Based Prognostic Model for ARDSRecruitingNCT069672071 country
- EIT-Guided Ventilator Settings in AHRFRecruitingNCT06936618Not applicable1 country
- Prevention of Lung Injury Induced by Mechanical Ventilation in Acute Respiratory Distress Syndrome ARDS PatientsNot yet recruitingNCT068358811 country
- Pleural Strain by Speckle-Tracking Ultrasound: Feasibility and Driving Pressure AssociationsRecruitingNCT069114501 country
- "Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"RecruitingNCT044847271 country
- Ventilation of the Extremely Premature Infants Optimized by Dead Space WashoutNot yet recruitingNCT06334523Not applicable1 country
- Evaluation of Respiratory Mechanics in Supine and PARK-bench Positions (SPARK)Enrolling by invitationNCT064489881 country
- Non-invasive Phrenic Nerve Stimulation in ARDS PatientRecruitingNCT06572280Not applicable1 country
- Optimizing the Assessment of Mechanical Ventilation by Integrating Advanced Monitoring Techniques [AVIM]Enrolling by invitationNCT06236685Not applicable1 country
- Effects of Individualized PEEP Guided by Driving Pressure on Postoperative Atelectasis in Patients With Morbid ObesityRecruitingNCT06181279Not applicable1 country
- Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor SurgeryNot yet recruitingNCT06421688Phase 21 country
- Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.RecruitingNCT063679461 country
- Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress SyndromeNot yet recruitingNCT06322758Not applicable
- Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung InjuryRecruitingNCT063214971 country
- Efficacy and Safety of Automated Closed-loop Ventilator vs Conventional Open-loop Ventilator in the Emergency DepartmentNot yet recruitingNCT06157073Not applicable
- Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal DeformationsRecruitingNCT04697498Not applicable1 country
- Mechanical Ventilation in Patients With Lung Impairment Controlled by the Mechanical Energy of the Respiratory SystemRecruitingNCT06035146Not applicable1 country
- The Effect of Two Different Intra-abdominal Pressure Applications on "Mechanical Power" in Laparoscopic CholecystectomyNot yet recruitingNCT058599061 country
- A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical VentilationTerminatedNCT03783884Not applicable3 countries
- Phrenic Identification in the ICUActive, not recruitingNCT058758831 country
- CT for Personalized Mechanical VentilationActive, not recruitingNCT05977153Not applicable1 country
- Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.Active, not recruitingNCT06737432Not applicable1 country
- Pragmatic Research on Diuretic Management in Early BPD PilotCompletedNCT05898022Phase 41 country
- Dynamic Compliance-Guided Ventilation in Lumbar SurgeryCompletedNCT07349719Not applicable1 country
- Effect of End-inspiratory Airway Pressure Measurements on the Risk of VILI in Ventilated PatientsCompletedNCT059912581 country
- Assessing Ventilator Safety in Patients on Pressure-Support VentilationCompletedNCT05125952Not applicable1 country
- Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress SyndromeTerminatedNCT04012073Phase 31 country
- Comparing Mechanical Power in Different Inspiratory TimesCompletedNCT064134721 country
- Long Term Follow up of Children Enrolled in the REDvent StudyActive, not recruitingNCT037091991 country