ClinicalTrials.gg
Enrolling by invitationNCT03853772Updated Aug 26, 2026

The Johns Hopkins Heartburn Center Registry

An observational study in Gastroesophageal Reflux Disease, Barrett Esophagus and Laryngopharyngeal Reflux, sponsored by Johns Hopkins University. Enrolling by invitation at 9 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-26.

Primary conditionLaryngopharyngeal RefluxRegistry: Gastroesophageal RefluxReclassifiedWhy we changed it
Registry
Gastroesophageal Reflux — the first condition term the registry derived for this study.
ClinicalTrials.gg
Laryngopharyngeal Reflux
Why
  1. The study's listed conditions name Laryngopharyngeal Reflux, a narrower term within Gastroesophageal Reflux.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by Johns Hopkins University · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
2,000
Ages
18 Years and older
Sex
All
01

Study summary

A multi-center, multi-year registry of patients with gastroesophageal reflux disease (GERD) undergoing diagnostic evaluation and/or treatment of GERD and associated diseases and complications.

Read the detailed description

This registry is a prospective, multicenter registry of patients undergoing diagnostic evaluation and/or treatment of gastroesophageal reflux disease and associated diseases and complications.

Patients who are eligible will have disease and therapy-specific data collected throughout treatment and long-term (5-year) follow-up.

Electronic data capture via REDCap will be utilized for all sites.

02

Conditions studied

  • Gastroesophageal Reflux Disease
  • Barrett Esophagus
  • Laryngopharyngeal Reflux
  • Esophagitis
03

In context

Laryngopharyngeal Reflux Reclassified

56 studies on the registry are indexed under Laryngopharyngeal Reflux; 8 are open to participants now.

Browse Laryngopharyngeal Reflux studies →

Lead sponsor

Johns Hopkins University is the lead sponsor of 1,815 studies on the registry; 315 are open to participants now.

Of its 208 completed or terminated interventional studies of FDA-regulated products, 144 (69%) have results posted.

Compared within Laryngopharyngeal Reflux, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Gastroesophageal Reflux. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients referred by physicians having diagnostic evaluation or treatment for GERD.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Referred GERD patients willing to participate in long term follow-up (5 years)

Exclusion criteria

Exclusion Criteria:

  • Potential participants will be excluded if unwilling or unable to complete surveillance questionnaires through this registry
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
2,000 participants (estimated)
Target follow-up
5 Years
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. Demographic and clinical data obtained via chart review and questionnaires

    Establish a registry with collected data related to patients undergoing diagnostic evaluation and treatment of GERD and its associated diseases in multiple academic and community settings.

    Time frame: 5 years

07

Study locations

9 sites
08

References and documents

Individual participant data

Plan to share: Yes — Research projects will be submitted to host (currently JHU) and accepted project will be granted access to read only de-identified database.

Supporting information: Study protocol, Informed consent form

Time frame: minimum 6 years

Access criteria: Project submission to PI and or Heartburn Registry management team then if project accepted, security clearance and enrollment in REDCap and tutorial completions.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 26, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03853772
Collaborators
EndoGastric Solutions
Responsible party
Sponsor
First posted
Feb 26, 2019
Start date
Apr 27, 2019
Primary completion
Dec 2027 (estimated)
Completion
Dec 2028 (estimated)
Last update
Aug 26, 2026

Study contacts

Marcia Canto, MD
principal investigator · Johns Hopkins University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

No contact was published for this record. The registry link below has the sponsor’s details.

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