Drug
Tenecteplase clinical trials
Also written TNK-tPA, Metalyse and rhTNK-tPA.
- studies test it
- 93
- open now
- 34
- in phase 3
- 60
- first study started
- 2000
Keep track of what changes. Save the Tenecteplase studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
92 studies that test it; most in 2026 (12); 1 more planned to start later
| Year | Studies |
|---|---|
| 2000 | 1 |
| 2001 | 1 |
| 2003 | 1 |
| 2004 | 2 |
| 2005 | 1 |
| 2006 | 4 |
| 2007 | 2 |
| 2008 | 4 |
| 2009 | 1 |
| 2011 | 1 |
| 2012 | 2 |
| 2015 | 3 |
| 2016 | 3 |
| 2017 | 3 |
| 2018 | 2 |
| 2019 | 5 |
| 2020 | 3 |
| 2021 | 8 |
| 2022 | 7 |
| 2023 | 9 |
| 2024 | 6 |
| 2025 | 11 |
| 2026 | 12 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 4
- Phase 2
- 25
- Phase 3
- 60
- Phase 4
- 10
- No phase
- 1
What it is tested for
Each study’s main condition, where its own words name it.
- Stroke
- 10
Who runs them
Industry 15 · Other 78
Beijing Tiantan Hospital (12) · General Hospital of Shenyang Military Region (7) · Boehringer Ingelheim (7) · Genentech, Inc. (5) · Xuanwu Hospital, Beijing (4) · University of Calgary (4) · The First Affiliated Hospital of University of Science and Technology of China (3) · Xinqiao Hospital of Chongqing (2)
Often tested with
Tested in the same studies.
Tissue Plasminogen Activator (7) · Minimally Invasive Surgery (1) · Clopidogrel (1) · Reteplase (1) · NONO-42 (1) · Enoxaparin (1)
Studies
Open first, then newest update. How each study uses Tenecteplase is read from its arms, and is right about nine times in ten.
Testing it · 93
- Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular EventsRecruitingPhase 3Yongjun WangNCT07748039Written as rhTNK-tPA (0.25mg/kg)
- ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632RecruitingPhase 3University of CalgaryNCT06320431Written as Tenecteplase
- A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen WellRecruitingPhase 3Boehringer IngelheimNCT07361302Written as Tenecteplase
- Unknown Time of Onset Stroke RePerfusIon Without Advanced ImagingRecruitingPhase 3First Affiliated Hospital of Guangxi Medical UniversityNCT07475949Written as Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Tenecteplase for Acute Ischemic Stroke Within 4.5 to 6 Hours of Onset (EXIT-BT2)RecruitingPhase 4General Hospital of Shenyang Military RegionNCT06010628Written as Tenecteplase
- Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 HoursRecruitingPhase 3Xuanwu Hospital, BeijingNCT07253181Written as Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- ACT-GLOBAL Adaptive Platform Trial for StrokeRecruitingPhase 3The George InstituteNCT06352632Written as Low-dose intravenous tenecteplase
- rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time WindowRecruitingPhase 3Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT07606807Written as Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg)
- Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral AnticoagulantNot yet recruitingPhase 3Hackensack Meridian HealthNCT07621796Written as Intravenous tenecteplase (TNK)
- Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation StrokeRecruitingPhase 2/3University of MelbourneNCT05105633Written as Tenecteplase
- Tenecteplase (TNK) in the Treatment of Intracerebral Hemorrhage (ICH)Not yet recruitingPhase 1Gaurav Gupta, MDNCT06696131Written as TNK
- Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR MismatchNot yet recruitingPhase 3The First Affiliated Hospital of Zhengzhou UniversityNCT07540416Written as TNK-tPA
- Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion StrokeRecruitingPhase 3Xuanwu Hospital, BeijingNCT06658197Written as Tenecteplase
- Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-BEYONDRecruitingPhase 3Beijing Tiantan HospitalNCT06954155Written as Tenecteplase (0.25mg/kg)
- Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours of Onset With Tenecteplase (RITIS-TNK2)RecruitingPhase 2General Hospital of Shenyang Military RegionNCT07375966Written as Tenecteplase
- Repeated Intravenous Thrombolysis for Ischemic Stroke Within 3.0 Hours of Onset With Tenecteplase (RITIS-TNK)RecruitingPhase 2General Hospital of Shenyang Military RegionNCT07375953Written as Tenecteplase
- Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Tenecteplase in Medium Vessel Occlusion (MeVO) for Acute Ischemic StrokeRecruitingPhase 3Beijing Tiantan HospitalNCT07047014Written as Tenecteplase (0.25mg/kg)
- Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 HoursRecruitingPhase 4Xuanwu Hospital, BeijingNCT07203625Written as Tenecteplase thrombolysis
- Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time WindowNot yet recruitingPhase 3First Hospital of China Medical UniversityNCT07476898Written as Tenecteplase (0.25mg/kg)
- Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical ThrombectomyNot yet recruitingPhase 3Chuansheng ZhaoNCT07471282Written as Tenecteplase (0.0938mg/kg)
See all 93 studies that test Tenecteplase →
As the comparator · 1 — what is tested is compared with Tenecteplase
Codes
What other systems call Tenecteplase · ClinicalTrials.gg INT006808
- MeSH (NLM) D000077785TenecteplaseConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) WGD229O42WTENECTEPLASEConfirmed FDA, NLM, Wikidata
- RxNorm 259280Confirmed FDA, Wikidata
- Wikidata Q1644947tenecteplaseConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C29489TenecteplaseOne source FDA
- DrugBank DB00031One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000077785 | Tenecteplase | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | WGD229O42W | TENECTEPLASE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 259280 | — | Confirmed FDA, Wikidata |
| Wikidata | Q1644947 | tenecteplase | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C29489 | Tenecteplase | One source FDA |
| DrugBank | DB00031 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.