An interventional study of Neuromuscular Electrical Stimulation (Sensory) and Neuromuscular Electrical Stimulation in Insulin Resistance, sponsored by University of Texas, El Paso. Recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-09.
Sponsored by University of Texas, El Paso · Not applicable, Interventional, and Prevention
Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55/15/30% CHO/PRO/FAT) prior to collection of pre-intervention data of insulin sensitivity. Individuals will then participate in an 8-week electrical stimulation intervention (30min/day, 3x/week) and randomized into placebo/control, NMES, resistance training combined with NMES (RT +NMES), or resistance training (RT) group (n=20 per group), followed by collection of post-intervention data. The control group will receive electrical stimulation up to sensory level, the NMES group will receive stimulation up to tolerable intensity to induce visible muscle contraction, the RT+ NMES will receive stimulation up to tolerable intensity during resistance training, and the RT group will only receive exercise training. Control and NMES group will self administer stimulation at home. Pre-and post-intervention data includes measurements for body composition, resting metabolic rate, VO2max, insulin sensitivity, and comprehensive blood work.
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
This study's planned enrollment of 80 is above the median of 40 across 1,536 interventional studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →University of Texas, El Paso is the lead sponsor of 20 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will receive stimulation only up to sensory level.
Device: Neuromuscular Electrical Stimulation (Sensory)
Participants will receive stimulation up to maximum tolerable level.
Device: Neuromuscular Electrical Stimulation
Participants will receive exercise training with stimulation up to sensory level.
Device: Neuromuscular Electrical Stimulation (Sensory) · Other: Resistance Training
Participants will receive exercise training with stimulation up to maximum tolerable intensity.
Device: Neuromuscular Electrical Stimulation · Other: Resistance Training
Group will receive Electrical Stimulation up to sensory level
Also known as: Control
Group will receive Electrical Stimulation up to maximum tolerable level
Also known as: NMES Group
Group will receive exercise training.
Also known as: Control
Glycemic Control
Insulin Sensitivity will be measured through repeated blood sampling during an Oral Glucose Tolerance Test and Continuous Glucose Monitoring
Time frame: 8 weeks
Respiratory Exchange Ratio
Respiratory Exchange Ratio will be used to quantify substrate utilization (fats vs carbohydrates) through the use of indirect calorimetry of in vivo gas exchange
Time frame: 8 Weeks
Amount of lean mass
Amount of lean mass will be measured by dual energy x-ray absortiometry
Time frame: 8 weeks
Plan to share: No
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University of Texas, El Paso