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Hyperinsulinism clinical trials

The registry lists 112 studies for Hyperinsulinism across more than 10 countries. 24 are recruiting or about to start. 18 of them are mainly about Hyperinsulinism (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its 4 narrower conditions too, such as Insulin Resistance: 4,853 studies, 655 open.

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Status

Completed
64
Recruiting
18
Withdrawn
7
Active, not recruiting
6
Status unknown
5
Terminated
5

Phase

Phase 2
20
Phase 1
19
Phase 3
6
Phase 4
3
Early Phase 1
2

Where

United States
56
Netherlands
8
United Kingdom
7
Italy
6
Canada
6
Switzerland
6

Who runs them

Columbia University (10) · Children's Hospital of Philadelphia (8) · National Heart, Lung, and Blood Institute (NHLBI) (4) · Rezolute (4) · Diva De Leon (3) · Yale University (3) · Maastricht University Medical Center (3) · University Hospital, Basel, Switzerland (3)

What is being tested here

Drugs under test in Hyperinsulinism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Fluorodopa F 18204
Alpelisib203
Diazoxide116
Ersodetug123
Glucose103
Insulin, Regular, Human102
Octreotide102
Glucagon102
Human Growth Hormone102
Dapagliflozin101

Coming up

3phase 3 studies under way
8studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 8, phase 3 first

Who these studies take

Of the 18 Hyperinsulinism studies recruiting now, 5 (28%) set no upper age limit and 11 (61%) stop at 75 or younger. 5 (28%) take children under 18. 6 (33%) are for women only and 0 (0%) for men only; 8 (44%) take healthy volunteers.

Recruiting studies that take each age, of 18
AgeWomenMen
104 (22%)4 (22%)
1817 (94%)12 (67%)
3016 (89%)11 (61%)
4016 (89%)11 (61%)
5012 (67%)10 (56%)
6512 (67%)10 (56%)
758 (44%)6 (33%)
857 (39%)5 (28%)

Across all 112 studies, recruiting or not: 73% stop at 75 or younger and 57% at 65; 32% take children; 16% are for women only and 8% for men only; 36% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Hyperinsulinism studies take

Of 24 interventional studies with no phase under Hyperinsulinism, half reached primary completion within 23 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase23 mo13–90 · 24 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

Studies

Recruiting first, then most recently updated. Showing 50 of 112. Browse all 112 → or search them.