Hyperinsulinism clinical trials
The registry lists 105 studies for Hyperinsulinism across more than 10 countries. 24 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-22.
Status
- Completed
- 59
- Recruiting
- 19
- Status unknown
- 7
- Withdrawn
- 6
- Active, not recruiting
- 4
- Not yet recruiting
- 3
Phase
- Phase 2
- 23
- Phase 1
- 19
- Phase 3
- 5
- Phase 4
- 2
- Early Phase 1
- 2
Where
- United States
- 55
- United Kingdom
- 8
- Israel
- 6
- Germany
- 5
- Canada
- 4
- Italy
- 4
Who runs them
Columbia University (9) · Children's Hospital of Philadelphia (8) · National Heart, Lung, and Blood Institute (NHLBI) (4) · Rezolute (4) · Yale University (3) · Diva De Leon (3) · Sheba Medical Center (2) · Vanderbilt University Medical Center (2)
Studies
Recruiting first, then most recently updated. Showing 50 of 105 — search for more.
- Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksRecruitingNCT033742151 country
- Graded Insulin Suppression Test P&FRecruitingNCT06592261Phase 11 country
- Alpelisib Challenge Test (ACT)RecruitingNCT07778524Phase 11 country
- Umbilical Cord GlucoseNot yet recruitingNCT07795047Not applicable
- Human Models of Selective Insulin Resistance: Alpelisib, Part IRecruitingNCT06354088Phase 11 country
- A Phase 3 Study of Ersodetug in Patients With Tumor HyperinsulinismRecruitingNCT06881992Phase 35 countries
- Effect of Insulin Lowering on LipogenesisRecruitingNCT07403604Phase 11 country
- Application of FreeStyle Libre 2 for Evaluating Glycemic Variability Characteristics in Patients With Extreme Glucose Metabolism PhenotypesNot yet recruitingNCT07564518
- Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant TherapyRecruitingNCT05989347Phase 11 country
- Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS DiagnosisRecruitingNCT059502821 country
- 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic HypoglycemiaAvailableNCT019161481 country
- Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast CancerRecruitingNCT05455619Phase 1/21 country
- Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 DiabetesRecruitingNCT05543083Not applicable1 country
- Effects of Antipsychotics on Brain Insulin Action in FemalesRecruitingNCT06251635Not applicable1 country
- Human Models of Selective Insulin Resistance: Pancreatic ClampNot yet recruitingNCT06558422Phase 11 country
- Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)RecruitingNCT064781211 country
- Utility of 18FDOPA PET/MRI for Focal HyperinsulinismRecruitingNCT05088798Phase 21 country
- Intermediate-Size Cohort EAP for Ersodetug in Patients With Inadequately Controlled Hypoglycemia Related to a TumorAvailableNCT07262970
- Noninvasive Evaluation of Fetal Hyperinsulinemia With Ultrasound RadiomicsRecruitingNCT063439741 country
- Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOSRecruitingNCT068894541 country
- Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes MellitusRecruitingNCT05662189Not applicable1 country
- Fluorodopa F 18 in Congenital Hyperinsulinism and InsulinomaRecruitingNCT02021604Phase 11 country
- The Movie Theater StudyRecruitingNCT06444984Not applicable1 country
- A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer.RecruitingNCT05753657Early Phase 11 country
- Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 DiabetesCompletedNCT00065676Phase 21 country
- Prevalenza Della Insulino Resistenza e Correlate Malattie Cardiovascolari Nella città di NapoliCompletedNCT077855181 country
- Diazoxide Suppression Test P&F StudyTerminatedNCT06606327Phase 11 country
- Effect of a Sugar Replacement on Blood Glucose Levels in Healthy AdultsActive, not recruitingNCT06714552Not applicable1 country
- Acute Microbial SwitchCompletedNCT05764200Not applicable1 country
- Reprometabolic Syndrome Mediates Subfertility in ObesityActive, not recruitingNCT02653092Not applicable1 country
- Pancreatic Clamp in NAFLDCompletedNCT05724134Phase 11 country
- RZ358 Treatment for Congenital HyperinsulinismActive, not recruitingNCT06208215Phase 313 countries
- Glycemic Effect of Diazoxide in NAFLDCompletedNCT05729282Phase 11 country
- Link Between the Peripheral Mononuclear Cells' Capacity to Induce Insulin Resistance and HyperinsulinemiaCompletedNCT05329337Not applicable1 country
- A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 DiabetesCompletedNCT04118374Not applicable1 country
- Continuous Glucose Monitoring in Neonatal HyperinsulinismTerminatedNCT063639291 country
- Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin ResistanceWithdrawnNCT04062890Phase 2
- An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital HyperinsulinismCompletedNCT04538989Phase 211 countries
- Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital HyperinsulinismCompletedNCT04172441Phase 2/34 countries
- Hyperinsulinemia in Prediabetes Mediated by Interleukin-1βCompletedNCT05854251Phase 21 country
- Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric HypoglycemiaCompletedNCT02996812Phase 11 country
- Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of InfancyCompletedNCT01070758Phase 41 country
- Increasing Insulin Resistance as a Predictor of Impending BacteremiaCompletedNCT049926891 country
- Effect of Alpelisib in Healthy VolunteersCompletedNCT05733455Phase 11 country
- A Two-Period Open-label Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital HyperinsulinismCompletedNCT03777176Phase 34 countries
- NUTRACORE, Glycaemic Index and AppetiteCompletedNCT05528874Not applicable1 country
- Developing a Physiological Understanding of High Duration ActivityActive, not recruitingNCT05135234Not applicable1 country
- Effect of Hibiscus Sabdariffa BeverageStatus unknownNCT05774613Not applicable1 country
- Vitamin E Efficacy in HI/HAWithdrawnNCT04984798Phase 21 country
- Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia SyndromeCompletedNCT03797222Not applicable1 country