Headache Disorders, Primary clinical trials
The registry lists 42 studies for Headache Disorders, Primary across more than 10 countries. 13 are recruiting or about to start. 19 of them are mainly about Headache Disorders, Primary (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-17. Counting its 5 narrower conditions too, such as Migraine Disorders: 1,927 studies, 384 open.
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Who runs them
Second Affiliated Hospital, School of Medicine, Zhejiang University (2) · Danish Headache Center (2) · University Hospital, Montpellier (2) · Hospital Clínico Universitario de Valladolid (2) · Assiut University (2) · Tashkent Medical Academy (1) · Tepecik Training and Research Hospital (1) · Charite University, Berlin, Germany (1)
What is being tested here
Drugs under test in Headache Disorders, Primary studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Islet Amyloid Polypeptide | 1 | 0 | 1 |
| Erenumab | 0 | 0 | 1 |
| Galcanezumab | 0 | 1 | 1 |
| Nitroglycerin | 0 | 0 | 1 |
| Sumatriptan | 0 | 0 | 1 |
| Naproxen | 0 | 0 | 1 |
| Doxycycline | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches · Texas Tech University Health Sciences Center
- Jun 2027Pericranial and General Sensitivity in Patients With Primary Headache · Universitat Internacional de Catalunya
- Oct 2027Prevalence of Primary Headache in Multiple Sclerosis Patients · Assiut University
Who these studies take
Of the 9 Headache Disorders, Primary studies recruiting now, 1 (11%) set no upper age limit and 5 (56%) stop at 75 or younger. 4 (44%) take children under 18. 1 (11%) are for women only and 0 (0%) for men only; 3 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (33%) | 3 (33%) |
| 18 | 8 (89%) | 7 (78%) |
| 30 | 8 (89%) | 7 (78%) |
| 40 | 8 (89%) | 7 (78%) |
| 50 | 7 (78%) | 7 (78%) |
| 65 | 6 (67%) | 6 (67%) |
| 75 | 4 (44%) | 4 (44%) |
| 85 | 4 (44%) | 4 (44%) |
Across all 42 studies, recruiting or not: 60% stop at 75 or younger and 55% at 65; 24% take children; 5% are for women only and 0% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 42 of 42. search them.
- Prevalence of Primary Headache in Multiple Sclerosis PatientsNot yet recruitingNCT07826221
- Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With HeadachesRecruitingNCT07309874Not applicable1 country
- China HeadAche DIsorders RegiStryRecruitingNCT053349271 country
- A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With MigraineRecruitingNCT07454798Not applicable1 country
- Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in MigraineRecruitingNCT06716489Not applicable1 country
- Pericranial and General Sensitivity in Patients With Primary HeadacheEnrolling by invitationNCT075142081 country
- Serum Uric Acid in Adolescents With Primary Headache: A Case-Control StudyNot yet recruitingNCT07460830
- Amylin-Induced Migraine Attacks Without AuraNot yet recruitingNCT07340788Not applicable1 country
- China Headache and Vertigo Registry StudyRecruitingNCT049399221 country
- International Headache Registry StudyRecruitingNCT054182181 country
- Triggers And Risk Factors to Develop a Reversible Cerebral Vasoconstriction SyndromeRecruitingNCT04179383Not applicable1 country
- Monoclonal Antibody Duration of REsponse in MIgraine After Treatment InterruptionRecruitingNCT052329421 country
- Digital-technology Based Interventions on Treatment of Migraine.RecruitingNCT05458817Not applicable1 country
- Effectiveness of Eye Mask and Headset in Primary HeadacheCompletedNCT04178252Not applicable1 country
- Treatment of Chronic Cluster Headache with TENS and ONSCompletedNCT05023460Not applicable1 country
- Pediatric Headche Assessment Using HIT 6CompletedNCT065988131 country
- Paracervical Injection for Headache in the Emergency DepartmentTerminatedNCT04109885Phase 21 country
- Efficacy of Erenumab in Chronic Cluster HeadacheCompletedNCT04970355Phase 21 country
- Feasibility of a Developmentally-tailored Mobile App for Tracking Mood and Pain in Children With MigraineWithdrawnNCT05337930Not applicable1 country
- Headache in Undergraduate Students and Biopsychosocial StatusCompletedNCT058437601 country
- Observational Prospective Study on the Presence of Typical Migraine Features in Nummular Headache Patients: The Numamig StudyCompletedNCT042999581 country
- Gender Differences and Features of the Clinical Course of Primary HeadachesStatus unknownNCT057606251 country
- Oxygen Therapy for HeadacheCompletedNCT055111551 country
- A Study of LY2951742 (Galcanezumab) in Participants With Cluster HeadacheCompletedNCT02797951Phase 312 countries
- Efficacy of Greater Occipital Nerve Radiofrequency for Refractory Migraine TreatmentCompletedNCT051990641 country
- Primary Headaches and Irritable Bowel Syndrome.Status unknownNCT050575331 country
- The Effect of Aerobic Exercise Training for Migraine Prevention.CompletedNCT01972607Not applicable1 country
- 1H Magnetic Resonance Spectroscopy in Migraine PatientsCompletedNCT04220606Not applicable
- Trigeminal Brainstem MappingCompletedNCT03999060Not applicable1 country
- Effectiveness of Osteopathic Manipulative Therapy in Paediatric Patients, With High Frequency Headache.Status unknownNCT04080258Not applicable1 country
- Predicting Migraine Attacks Based on Environmental and Behavioral Changes as Detected From the SmartphoneTerminatedNCT037629021 country
- Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global AmnesiaCompletedNCT037390081 country
- Muscle Tenderness and Hardness in Migraine PatientsCompletedNCT036268051 country
- Individualized Prediction of Migraine Attacks Using a Mobile Phone App and FitbitCompletedNCT029109211 country
- Comparing Naproxen to Sumatriptan for Emergency Headache PatientsCompletedNCT00449787Phase 41 country
- Primary Headache and Psychological Factors, Mental Functioning and Attachment Modalities.Status unknownNCT03499392Not applicable1 country
- IndoProCaf Effervescent Tablets Effectiveness in Acute Treatment of Migraine and/or Episodic Tension-type Headache and Patients' Satisfaction With the Treatment in Routine Clinical PracticeCompletedNCT021152692 countries
- The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute MigraineWithdrawnNCT01653522Not applicable1 country
- A Prospective Observational Registry of Primary Headache Patients Treated With AusanilTerminatedNCT023922731 country
- Acupuncture for Pain Control in the Emergency DepartmentTerminatedNCT02013908Not applicable1 country
- The Effects of Connective Tissue Massage and Lifestyle Modifications in Adolescents Tension Type HeadacheStatus unknownNCT02549300Not applicable1 country
- A Pilot Study of Migraine and Appetite Behaviour in ChildrenCompletedNCT009308521 country