CClinicalTrials.gg
Status unknownNCT04080258Updated Sep 16, 2019

Effectiveness of Osteopathic Manipulative Therapy in Paediatric Patients, With High Frequency Headache.

An interventional study of Osteopathic manipulative therapy (OMTh) and Light Touch Therapy (LTT) in Headache Disorders and Primary Headache Disorder, sponsored by Antonio Francesco Urbino. Status unknown at 1 site in Italy. Open to participants aged 8 Years to 18 Years. Per ClinicalTrials.gov, last updated 2019-09-16.

Sponsored by Antonio Francesco Urbino · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Sep 2019), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
90
Allocation
Randomized
Ages
8 Years to 18 Years
Sex
All
01

Study summary

The aim of this study is to evaluate the effectiveness of osteopathic manipulative therapy, in supporting prophylactic medications in paediatric patients, with high frequency headache.

Read the detailed description

Headache is one of the most common medical complaints in childhood, with migraine and tension-type headaches (TTHs) being the most frequent diseases. The prevalence of tension-type headache (TTH) varies from 10% to 25% in school children and adolescents. Therefore a range varying from 0,1% to 5,9% of this population presents chronic tension-type headache, occuring at least 15 days on a monthly basis.

The tension-type headache is most likely multifactorial. In children, a connection seems possible between tension-type headache and psychosocial stress, psychiatric disorders, muscular stress, or oromandibular dysfunction.

The treatment of tension-type headache covers a systemic approach that includes both pharmacologic and nonpharmacologic therapies, such as biobehavioural management, and patient and family education regarding lifestyle modifications to develop and/or maintain healthy habits. Efficacy of these therapies is still unclear. Complementary therapies could be a good support to pharmacologic treatment. Osteopathic treatment results effective in some paediatric conditions, but in primary headache the possible efficacy is still unknown.

02

Conditions studied

  • Headache Disorders
  • Primary Headache Disorder

Keywords

  • Headache Disorders
  • Primary Headache
03

Who can participate

Ages eligible
8 Years to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosis of primary high-frequency headache attacks.
  • No reduction or inconsistent reduction of attacks after two months of prophylactic treatment.

Exclusion criteria

Exclusion Criteria:

Secondary headache.

04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
90 participants (estimated)

Study arms

  • Experimental
    Osteopathic Manipulative Therapy

    Osteopathic Manipulative Therapy (OMTh). Patients in the OMTh group will receive 5 Osteopathic manipulative therapies: the first at baseline, the second after 1 week, the third after 3 weeks, and then 2 more treatments on a monthly basis. The protocol will last for three months.

    Other: Osteopathic manipulative therapy (OMTh)

  • Sham comparator
    Light Touch Therapy

    Participants to the LTT group will receive the protocol at the same date of the OMTh group.

    Other: Light Touch Therapy (LTT)

Interventions

  • OtherOsteopathic manipulative therapy (OMTh)

    The Osteopathic Manipulative Therapy includes both evaluation and treatment. The evaluation is semi-structured, two osteopaths will assess the presence of somatic dysfunctions which have to include the hyoid-pharyngeal, laryngeal, temporo-mandibular and lingual areas. The therapy is based on the treatment of somatic dysfunctions with different approaches that include: the balanced ligamentous tension technique, the myofascial release, the visceral manipulation, and the balanced membranous tension technique. The OMTh lasts for 45 minutes of which 15 of evaluation and 30 of treatment.

  • OtherLight Touch Therapy (LTT)

    The Light Touch Therapy is a sham treatment consistent with the OMTh one during the phase of evaluation. The treatment retains the same areas used for osteopathic approach but avoids prolonged touch in any area of the body by moving the hands every few seconds and by flattening and softening the surface of the hands in order to minimize focal areas of force.

05

What researchers measure

Primary outcomes

  1. Number of days with headache

    Difference in number of days per month with headache

    Time frame: At baseline (T0), after 1 month (T1), at 3 months from baseline (T2) and follow-up at 6 months from baseline.

Secondary outcomes

  1. Reduction of analgesic use

    Difference in reduction of analgesic use per month

    Time frame: At baseline (T0), after 1 month (T1), at 3 months form baseline (T2) and follow-up at 6 months from baseline

  2. Reduction of functional disability (school and leisure activity)

    Days per month with functional disability.

    Time frame: At baseline (T0), after 1 month (T1), at 3 months form baseline (T2) and follow-up at 6 months from baseline

  3. Reduction of headache intensity

    Difference in intensity of pain: mild, moderate and severe

    Time frame: At baseline (T0), after 1 month (T1), at 3 months form baseline (T2) and follow-up at 6 months from baseline

  4. Adverse event

    Symptoms such as increased of pain that could occur after the Osteopathic Manipulative Therapy or Light Touch Therapy

    Time frame: From first treatment (1 week post-baseline) up to end of treatment course (3 months).

06

Study locations

1 of 1 sites recruiting
  • Centro Cefalee dell'età evolutiva - Ospedale Infantile Regina Margherita S.C. Pediatria d'Urgenza.
    Torino, 10126, Italy
    • Antonio F Urbino, Medical · Contact
    Recruiting
07

References and documents

Publications

  • Huguet A, Tougas ME, Hayden J, McGrath PJ, Chambers CT, Stinson JN, Wozney L. Systematic Review of Childhood and Adolescent Risk and Prognostic Factors for Recurrent Headaches. J Pain. 2016 Aug;17(8):855-873.e8. doi: 10.1016/j.jpain.2016.03.010. Epub 2016 Apr 19. PubMed 27102894 ↗
  • Gofshteyn JS, Stephenson DJ. Diagnosis and Management of Childhood Headache. Curr Probl Pediatr Adolesc Health Care. 2016 Feb;46(2):36-51. doi: 10.1016/j.cppeds.2015.11.003. Epub 2015 Dec 29. PubMed 26750538 ↗
  • Kroon Van Diest AM, Powers SW. Cognitive Behavioral Therapy for Pediatric Headache and Migraine: Why to Prescribe and What New Research Is Critical for Advancing Integrated Biobehavioral Care. Headache. 2019 Feb;59(2):289-297. doi: 10.1111/head.13438. Epub 2018 Nov 16. PubMed 30444269 ↗
  • Posadzki P, Lee MS, Ernst E. Osteopathic manipulative treatment for pediatric conditions: a systematic review. Pediatrics. 2013 Jul;132(1):140-52. doi: 10.1542/peds.2012-3959. Epub 2013 Jun 17. PubMed 23776117 ↗
  • Cerritelli F, Ginevri L, Messi G, Caprari E, Di Vincenzo M, Renzetti C, Cozzolino V, Barlafante G, Foschi N, Provinciali L. Clinical effectiveness of osteopathic treatment in chronic migraine: 3-Armed randomized controlled trial. Complement Ther Med. 2015 Apr;23(2):149-56. doi: 10.1016/j.ctim.2015.01.011. Epub 2015 Jan 21. PubMed 25847552 ↗
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Registry details

Key details

Study ID
NCT04080258
Lead sponsor
Antonio Francesco Urbino
Collaborators
Scuola Superiore di Osteopatia Italiana
Responsible party
Antonio Francesco Urbino (Director Pediatric Department, A.O.U. Città della Salute e della Scienza) — Sponsor-investigator
First posted
Sep 6, 2019
Start date
Jun 18, 2018
Primary completion
Jun 18, 2020 (estimated)
Completion
Dec 18, 2020 (estimated)
Last update
Sep 16, 2019

Study contacts

Donatella F Bagagiolo, Osteopath
Contact
donatella.bagagiolo@gmail.com
0039 3405587818
Antonia Versace, Medical
Contact
aversace@cittadellasalute.to.it
00390113131735
Antonio F Urbino, Medical
principal investigator · A.O.U. Città della Salute e della Scienza

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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