CClinicalTrials.gg
TerminatedNCT02392273Updated Dec 28, 2016

A Prospective Observational Registry of Primary Headache Patients Treated With Ausanil

An observational study in Primary Headache Disorders, sponsored by VR1 Corporation. Terminated at 1 site in United States. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-12-28.

Sponsored by VR1 Corporation · Observational

Why this study was terminated
Study unable to recruit
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
20
Ages
18 Years to 80 Years
Sex
All
01

Study summary

This study is an observational study with the primary objective to assess the safety and tolerability of Ausanil in the treatment of primary headache disorders. The secondary objective is to assess headache pain, functional outcome, time loss to headache and patient satisfaction with Ausanil treatment.

02

Conditions studied

  • Primary Headache Disorders

Keywords

  • migraine
  • cluster headache
  • primary headache
  • Ausanil
  • capsicum annuum
03

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients in a Clinical headache practice (outpatient) with a diagnosis of a primary headache disorder.

Inclusion criteria

  • Men and women aged 18 to 80 years
  • Primary Headache disorder as per International Classification of Headache Disorders-11
  • Ausanil naive
  • Signed dated informed consent
  • Females of childbearing potential must be using adequate contraception during study period.
  • Willing and able to comply with registry requirements to document headache response

Exclusion criteria

Exclusion Criteria:

  • Known allergy to Ausanil or any of its ingredients
  • Active bronchial asthma that in the opinion of the investigator would interfere with use of Ausanil
  • Nasal obstruction due to any cause or extensive nasal surgery resulting in scarring or other such impact on nasal mucosa that might lead to heightened sensitivity to Ausanil in the opinion of the investigator.
  • Pregnant or breast feeding females
  • History of addictive behavior
  • Any severe or chronic unstable medical or psychiatric condition
  • Active nasal infection or inflammation
  • Unable or unwilling to provide informed consent
  • Suffer from atypical, basilar or hemiplegic migraine that is new onset or unstable.
04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
20 participants (actual)
Patient registry
No

Interventions

  • DrugAusanil

    Patients with Primary Headache disorders will receive Ausanil in the context of usual and routine clinical care.

    Also known as: capsicum annuum

05

What researchers measure

Primary outcomes

  1. Incidence of Adverse Events (all cause)

    Patient/Physician reporting

    Time frame: 8 weeks

  2. Incidence of Adverse Events causally related to Ausanil

    Patient/Physician reporting

    Time frame: 8 weeks

  3. Serious Adverse Events

    Patient/Physician reporting

    Time frame: 8 weeks

Secondary outcomes

  1. Headache Response to Ausanil

    Change in Headache severity on a four point scale (0-3) will be measured at 5 minutes, one hour, two hours and twenty four hours

    Time frame: 24 hours

  2. Functional Assessment

    Improvement in ability to function after Headache treatment

    Time frame: 24 Hours

  3. Patient satisfaction for Treatment

    Patients will be asked to rate their satisfaction with treatment on a 7 point scale (very dissatisfied to very satisfied)

    Time frame: 24 hours

  4. Time Loss to headache

    How many hours of function were lost as result of the headache?

    Time frame: 24 hours

  5. Use of Rescue Medication

    Frequency of Rescue medication will be tabulated

    Time frame: 24 hours

  6. Sting severity and duration

    How long does the sting associated with Ausanil treatment last?

    Time frame: one hour

06

Study locations

1 site
  • Atlantic Health System/Overlook Medical Center Medical Arts Center
    Summit, New Jersey 07901, United States
07

Registry details

Key details

Study ID
NCT02392273
Lead sponsor
VR1 Corporation
Responsible party
Sponsor
First posted
Mar 18, 2015
Start date
Feb 2015
Primary completion
Dec 2016 (estimated)
Completion
Jan 2017 (estimated)
Last update
Dec 28, 2016

Study contacts

Seth Stoller, MD
principal investigator · Atlantic Health System

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is terminated, as verified in Dec 2016. You cannot join it, but the record below documents what was studied.

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