Diverticulitis clinical trials
The registry lists 125 studies for Diverticulitis across more than 10 countries. 22 are recruiting or about to start. 71 of them are mainly about Diverticulitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Diverticulitis, Colonic too: 145 studies, 29 open.
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Who runs them
University Hospitals Cleveland Medical Center (5) · Herlev Hospital (4) · McGill University Health Centre/Research Institute of the McGill University Health Centre (3) · Dr. Falk Pharma GmbH (3) · Uppsala University (3) · University of Washington (3) · University of Roma La Sapienza (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2)
What is being tested here
Drugs under test in Diverticulitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Mesalamine | 0 | 3 | 4 |
| Metronidazole | 0 | 0 | 3 |
| Amoxicillin | 0 | 0 | 2 |
| Clavulanic Acid | 0 | 0 | 2 |
| Probiotic | 0 | 1 | 2 |
| Tigecycline | 0 | 0 | 2 |
| Ceftriaxone | 0 | 0 | 2 |
| Lidocaine | 0 | 0 | 2 |
| Prebiotics | 0 | 0 | 1 |
| Bupivacaine | 0 | 0 | 1 |
Drug classes tested here Local anesthetics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026Quality of Life in Acute Complicated and Chronic Recurrent Left-sided Diverticulitis · Kepler University Hospital
- Feb 2027Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial · University of Washington
- Mar 2027Anastomotic Leakage After Colorectal Surgery. · Minia University
- Apr 2027Improving the Treatment of Acute Uncomplicated Diverticulitis in Routine Care · Ente Ospedaliero Cantonale, Bellinzona
- Apr 2027Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study · True Bearing Diagnostics, Inc.
- Apr 2027Clinical Trial With MBK-01, Intestinal Microbiota Capsules, for the Treatment of Patients With Recurrent Diverticulitis · Mikrobiomik Healthcare Company S.L.
Who these studies take
Of the 16 Diverticulitis studies recruiting now, 10 (63%) set no upper age limit and 1 (6%) stop at 75 or younger. 3 (19%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (19%) | 3 (19%) |
| 18 | 16 (100%) | 16 (100%) |
| 30 | 16 (100%) | 16 (100%) |
| 40 | 16 (100%) | 16 (100%) |
| 50 | 16 (100%) | 16 (100%) |
| 65 | 16 (100%) | 16 (100%) |
| 75 | 15 (94%) | 15 (94%) |
| 85 | 13 (81%) | 13 (81%) |
Across all 125 studies, recruiting or not: 6% stop at 75 or younger and 1% at 65; 13% take children; 1% are for women only and 1% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Diverticulitis studies take
Of 22 observational studies under Diverticulitis, half reached primary completion within 40 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 36 mo12–57 · 16 studies | — | — |
| Observational | 40 mo16–101 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 125. Browse all 125 → or search them.
- Anastomotic Leakage After Colorectal Surgery.RecruitingNCT071446831 country
- Improving the Treatment of Acute Uncomplicated Diverticulitis in Routine CareNot yet recruitingNCT07824180Not applicable
- APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)RecruitingNCT07492134Phase 21 country
- Bowel Function/QoL After Elective Sigmoidectomy vs. Conservative Management for Recurrent Uncomplicated DiverticulitisRecruitingNCT039949781 country
- Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL StudyRecruitingNCT075793121 country
- Anastomotic Bleeding in Colorectal Anastomosis Relating to the Placement of the Stapler Spike to the Staple LineRecruitingNCT075060051 country
- Quality of Life in Acute Complicated and Chronic Recurrent Left-sided DiverticulitisRecruitingNCT05942833Not applicable2 countries
- Percutaneous Drainage Versus Antibiotic Therapy for Acute Diverticulitis With Abscess.Not yet recruitingNCT07352605Not applicable
- Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute DiverticulitisNot yet recruitingNCT070270071 country
- Clinical Trial With MBK-01, Intestinal Microbiota Capsules, for the Treatment of Patients With Recurrent DiverticulitisRecruitingNCT06687382Phase 21 country
- Surgical Site Infection Outcomes in Natural Orifice Intracorporeal Anastomosis and Extraction (NICE) Procedure - The NICE TrialEnrolling by invitationNCT069572361 country
- Comparison of NOM for ACLD Between Medical and Surgical WardRecruitingNCT062656491 country
- Screening for Hepatitis Virus B Protein X (HBx) in Colitis-associated Cancer (CAC)Not yet recruitingNCT068330211 country
- RObotic Versus LAparoscopic Colectomy for DIverticulitis.RecruitingNCT058293431 country
- FIT in DiverticulitisRecruitingNCT062107241 country
- Damage Control Surgery Over the World in Acute Diverticulitis (DACOSAD)RecruitingNCT064283702 countries
- The COLD2B Multicenter, Two-arm Prospective Cohort StudyNot yet recruitingNCT063885381 country
- Surgical Italian Guide for the Management of Complicated Acute Diverticulitis Emergency Setting (SIGMA-D). A Prospective Observational Multicenter Study on Behalf of the Italian Society of Colorectal Surgery (SICCR).RecruitingNCT063440781 country
- Incidence and Outcome of Acute Diverticulitis in FinlandRecruitingNCT051625601 country
- Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (SUDD)RecruitingNCT05596214Phase 21 country
- The Damage Control Strategy for the Treatment of Perforated Diverticulitis of the Sigmoid Colon With Diffuse PeritonitisRecruitingNCT042208401 country
- Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)RecruitingNCT052578631 country
- Developing a Decision Tool for Diverticulitis in the Emergency Department Using UltrasoundCompletedNCT058322421 country
- Scandinavian Diverticulitis Trial SCANDIV-IICompletedNCT042542241 country
- Comparison of Quality of Life and Functionnal Resultats After Sigmodectomy Between Diverticulitis and CancerCompletedNCT047292831 country
- Investigation of Medical Management to Prevent Episodes of Diverticulitis TrialCompletedNCT05681559Not applicable1 country
- FMT in Uncomplicated DiverticulitisActive, not recruitingNCT05373784Early Phase 11 country
- Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) TrialActive, not recruitingNCT04095663Not applicable1 country
- Is It So Hard To Predict Complicated Diverticulitis?CompletedNCT073229261 country
- Informativeness to Digital Rectal ExaminationCompletedNCT01727388Phase 31 country
- Clinical Database of Colorectal Robotic SurgeryActive, not recruitingNCT040131521 country
- Point of Care 3D Ultrasound for Various Applications: A Pilot StudyCompletedNCT028315561 country
- Vacuum Assisted Therapy in Emergent Contaminated Abdominal SurgeriesCompletedNCT02127164Not applicable1 country
- Trial Assessing the Efficacy of a Short Course of Intravenous Antibiotic Followed by Oral Antibiotic in Uncomplicated Acute DiverticulitisCompletedNCT00917592Phase 41 country
- Effect of Gum Arabic on Gastrointestinal Transit and PermeabilityCompletedNCT03742076Not applicable1 country
- Management of Diverticulitis in the Emergency DepartmentCompletedNCT040439881 country
- Endoscopic Management Of Controlled Colo-cutaneous Fistula As A Complication of Acute Sigmoid Diverticulitis: A Randomized Controlled TrialCompletedNCT05834985Not applicable1 country
- Acute Uncomplicated Diverticulitis and Conservative Treatment: Accuracy of Inflammatory Indexes for Failure Prediction: Observational Prospective Cohort Study. (AUDRIP Trial)Status unknownNCT058336981 country
- A National Study of Clinical Results After Emergency Operation for Perforated DiverticulitisCompletedNCT033325501 country
- Multicenter Survey About Acute Uncomplicated Diverticulitis ManagementStatus unknownNCT057840641 country
- DEBUT: Diverticulitis Evaluation of Patient Burden, Utilization, and TrajectoryCompletedNCT027767871 country
- Acute Diverticulitis and Advanced Colonic Neoplasia. When to Perform Colonoscopy (ADACOLON Study)CompletedNCT03557216Not applicable1 country
- Prior Abdominal Surgery: A Potential Risk Factor for Colonic Diverticulosis or DiverticulitisCompletedNCT053849251 country
- General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)CompletedNCT006225571 country
- Supplementation With Lacobacillus Reuteri ATCC PTA 4659 in Patients Affected by Acute Uncomplicated DiverticulitisCompletedNCT03656328Not applicable1 country
- Confocal Laser Endomicrospy in Colonic Diverticular DiseaseCompletedNCT041731821 country
- Predictive Time-to-Event Model for Major Medical Complications After ColectomyStatus unknownNCT051505481 country
- Single Port Colic Laparoscopic SurgeryCompletedNCT01959087Not applicable1 country
- Rifaximin Delayed Release for the Prevention of Recurrent Acute Diverticulitis and Diverticular Complications.TerminatedNCT03469050Phase 2/36 countries
- Does Caffeine Reduce Postoperative Bowel Paralysis After Elective Colectomy?TerminatedNCT02510911Not applicable1 country