An interventional study of High-dose prebiotic and Low-dose prebiotic in Diverticulitis, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-07-10.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Other
The study aims to determine the effect of gum arabic on gut bacteria and GI function.
To compare the effect of placebo, low-dose prebiotic, or high-dose prebiotic on gut microbiota composition and function, GI transit and permeability, and assess development of symptoms or a change in pre-existing symptoms present, in patients with recent history of clinically diagnosed diverticulitis which has been successfully treated.
125 studies on the registry are indexed under Diverticulitis; 22 are open to participants now.
This study's enrollment of 27 is below the median of 120 across 63 interventional studies indexed under Diverticulitis.
Browse Diverticulitis studies →Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.
Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A planned gap after a treatment, so that its effects can lessen before the study treatment or a study assessment. Ask the study team and the doctor who prescribed it before changing any medicine.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Washout period
A planned gap after a treatment, so that its effects can lessen before the study treatment or a study assessment. Ask the study team and the doctor who prescribed it before changing any medicine.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
10 gm gum arabic (powder) with 2 gm fiber powder daily for at least 6 weeks
Dietary Supplement: High-dose prebiotic
5 gm gum arabic (powder) with 2 gm fiber powder daily for at least 6 weeks
Dietary Supplement: Low-dose prebiotic
2 gm powdered fiber daily for at least 6 weeks
Dietary Supplement: Placebo
This is a spray-dried powder, yellowish-white in color, that is dissolvable.
Also known as: Acacia, gum acacia, acacia gum, gum arabic, arabic gum
This is a spray-dried powder, yellowish-white in color, that is dissolvable.
Also known as: Acacia, gum acacia, acacia gum, gum arabic, arabic gum
Powder fiber supplement, yellowish-white in color, that is dissolvable.
Also known as: Dextrin fiber powder
Colonic Transit time
The scintigraphic method is used to measure colonic transit. An isotope is adsorbed on activated charcoal particles and delivered to the colon in a delayed release capsule. Anterior and posterior gamma images are taken hourly. The geometric center (GC) is the weighted average of counts in the different colonic regions. The scale ranges from 1 to 5; a high GC implies faster colonic transit, a GC of 1 implies all isotope is in the ascending colon, and a GC of 5 implies all isotope is in the stool. Units: units on a scale
Time frame: Change is being assessed between baseline and 6 weeks
Intestinal Permeability
To determine intestinal permeability, urine will be collected for 24 hours after drinking a sugar solution. The 0- to 2-hour urine most closely reflects small intestinal permeability and the 8- to 24-hour urine reflects colonic permeability. HPLC-tandem mass spectrometry will be used for detection of the sugars.
Time frame: Change is being assessed between baseline and 6 weeks
This study is completed, as verified in Jul 2023. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Prebiotics