An interventional study of standardized treatment algorithm in Diverticulitis, sponsored by Ente Ospedaliero Cantonale, Bellinzona. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by Ente Ospedaliero Cantonale, Bellinzona · Not applicable, Interventional, and Treatment
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary. This study will evaluate whether a more standardized approach to treatment can reduce unnecessary antibiotic use without increasing the risk of treatment failure.
The study will compare patients treated before and after the new treatment approach is introduced in participating Swiss hospitals. Information on treatment, hospital admissions, complications and recurrence of diverticulitis will be collected. Patients will be followed for up to 24 months.
125 studies on the registry are indexed under Diverticulitis; 22 are open to participants now.
This study's planned enrollment of 800 is above the median of 120 across 63 interventional studies indexed under Diverticulitis.
Browse Diverticulitis studies →Ente Ospedaliero Cantonale, Bellinzona is the lead sponsor of 38 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Diverticulitis of the right or transverse colon
-.Alternative diagnosis explaining the participant's symptoms
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants with acute uncomplicated diverticulitis who receive antibiotic treatment according to the standardized treatment approach.
Other: standardized treatment algorithm
Participants with acute uncomplicated diverticulitis who are managed without antibiotics according to the standardized treatment approach.
Other: standardized treatment algorithm
A standardized treatment approach based on clinical findings, laboratory results, comorbidities, immunosuppression status, and CT findings is introduced to support treatment decisions in patients with acute uncomplicated diverticulitis. Depending on these factors, patients may be managed with or without antibiotics.
Treatment failure
Treatment failure is defined as a composite outcome including progression to complicated diverticulitis requiring percutaneous abscess drainage or surgery, delayed initiation of antibiotics after initial management without antibiotics, or unplanned hospital admission following initial outpatient treatment.
Time frame: Within 90 days after diagnosis
Antibiotic use
Proportion of participants receiving antibiotics
Time frame: Within 90 days after diagnosis
Adherence to the standardized treatment approach
Proportion of participants whose management is consistent with the standardized treatment approach.
Time frame: At the initial treatment decision
Outpatient versus inpatient management
Proportion of participants initially managed as outpatients versus inpatients.
Time frame: At the initial treatment decision
Hospital admission
Proportion of participants readmitted to hospital.
Time frame: Within 30 days after diagnosis
Recurrence of diverticulitis
Proportion of participants experiencing recurrence of diverticulitis.
Time frame: Within 24 months after diagnosis
No study locations are listed for this record.
Start is estimated for Oct 2026; primary completion for Apr 2027, 6 months later.
Of 16 interventional studies with no phase under Diverticulitis, half reached primary completion within 36 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 57. This study's planned 6 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Ente Ospedaliero Cantonale, Bellinzona