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CompletedNCT07322926Updated Jan 7, 2026

Is It So Hard To Predict Complicated Diverticulitis?

An observational study in Diverticulitis, sponsored by Haydarpasa Numune Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-07.

Sponsored by Haydarpasa Numune Training and Research Hospital · Observational

Study type
Observational
Model
Other
Time perspective
Retrospective
Enrollment
101
Ages
18 Years and older
Sex
All
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Study summary

Is It So Hard To Predict Complicated Diverticulitis?

Objective: Acute diverticulitis (AD) is a frequent cause of abdominal pain leading to emergency department visits. Many biomarkers have been identified to predict the risk of developing complicated diverticulitis. In our study, we aimed to reveal the sensitivity of these biomarkers in order to better differentiate uncomplicated AD from complicated ones.

Methods: 101 patients who were diagnosed with AD in the emergency outpatient clinic between 2018 and 2022, registered in the database of our hospital, were evaluated retrospectively. Demographic data of the patients and laboratory results at the time of admission were evaluated. Patients were classified as having non-complicated (Group I) or complicated diverticulitis (Group II) based on the World Society of Emergency Surgery (WSES) criteria. Laboratory values at admission, including albumin, white blood cell count (WBC), C-reactive protein (CRP), neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), were evaluated.

Read the detailed description

101 patients who were diagnosed with AD in the emergency outpatient clinic between 2018 and 2022, registered in the database of our hospital, were evaluated retrospectively. Demographic data of the patients and laboratory results at the time of admission were evaluated. Patients were classified as having non-complicated (Group I) or complicated diverticulitis (Group II) based on the World Society of Emergency Surgery (WSES) criteria. Laboratory values at admission, including albumin, white blood cell count (WBC), C-reactive protein (CRP), neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), were evaluated.

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Conditions studied

  • Diverticulitis

Keywords

  • Diverticulitis
  • neutrophil-to-lymphocyte ratio
  • lymphocyte-to-monocyte ratio
  • emergency
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In context

Diverticulitis

125 studies on the registry are indexed under Diverticulitis; 22 are open to participants now.

This study's enrollment of 101 is below the median of 275 across 59 observational studies indexed under Diverticulitis.

Browse Diverticulitis studies →

Lead sponsor

Haydarpasa Numune Training and Research Hospital is the lead sponsor of 33 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

101 patients who were admitted to the Haydarpaşa Numune Training and Research Hospital General Surgery Clinic with the diagnosis of first acute diverticulitis attack between the years 2018-2022 were chosen.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Admission to the Haydarpaşa Numune Training and Research Hospital General Surgery Clinic
  • First episode of acute diverticulitis
  • Diagnosis confirmed by contrast-enhanced abdominal computed tomography (CT)
  • Admission between 2018 and 2022
  • Retrospective identification from the hospital registry system

Exclusion criteria

Exclusion Criteria:

  • Recurrent episodes of diverticulitis
  • History of prior colorectal surgery
  • Symptom duration longer than 7 days before admission
  • Inconsistent physical examination findings with laboratory or imaging results
  • Age under 18 years
  • confirmed
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Histologically or cytologically confirmed

The diagnosis was confirmed by looking at a sample under a microscope: tissue from a biopsy or surgery (histology), or cells from a fluid or needle sample (cytology).

Your pathology report is the document that shows this.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

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Study design

Observational model
Other
Time perspective
Retrospective
Enrollment
101 participants (actual)
Patient registry
No

Groups and cohorts

  • Patient with left colonic diverticulitis

    no intervention

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What researchers measure

Primary outcomes

  1. Number of participants diagnosed with complicated acute diverticulitis according to the WSES classification

    Acute diverticulitis severity will be classified using the World Society of Emergency Surgery (WSES) diverticulitis grading system based on contrast-enhanced abdominal computed tomography (CT) findings at the time of admission. Patients will be categorized as having uncomplicated diverticulitis (WSES grades 1a and 1b) or complicated diverticulitis (WSES grades 2, 3, and 4). The primary outcome is the number of participants diagnosed with complicated diverticulitis.

    Time frame: Time frame is the length of stay usually between 1-14 days

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Study locations

1 site
  • Haydarpasa Numune Research and Training Hospital
    Istanbul, 34668, Turkey (Türkiye)
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References and documents

Publications

  • Chabok A, Andreasson K, Nikberg M. Low risk of complications in patients with first-time acute uncomplicated diverticulitis. Int J Colorectal Dis. 2017 Dec;32(12):1699-1702. doi: 10.1007/s00384-017-2912-7. Epub 2017 Oct 16. PubMed 29038965 ↗
  • Feingold D, Steele SR, Lee S, Kaiser A, Boushey R, Buie WD, Rafferty JF. Practice parameters for the treatment of sigmoid diverticulitis. Dis Colon Rectum. 2014 Mar;57(3):284-94. doi: 10.1097/DCR.0000000000000075. No abstract available. PubMed 24509449 ↗
  • Zaborowski AM, Winter DC. Evidence-based treatment strategies for acute diverticulitis. Int J Colorectal Dis. 2021 Mar;36(3):467-475. doi: 10.1007/s00384-020-03788-4. Epub 2020 Nov 6. PubMed 33156365 ↗
  • Biondo S, Golda T, Kreisler E, Espin E, Vallribera F, Oteiza F, Codina-Cazador A, Pujadas M, Flor B. Outpatient versus hospitalization management for uncomplicated diverticulitis: a prospective, multicenter randomized clinical trial (DIVER Trial). Ann Surg. 2014 Jan;259(1):38-44. doi: 10.1097/SLA.0b013e3182965a11. PubMed 23732265 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 7, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07322926
Lead sponsor
Haydarpasa Numune Training and Research Hospital
Responsible party
Naz Tayyar (Resident, Haydarpasa Numune Training and Research Hospital) — Principal investigator
First posted
Jan 7, 2026
Start date
Sep 1, 2023
Primary completion
Jan 24, 2024
Completion
Jan 25, 2024
Last update
Jan 7, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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