An observational study in Sigmoid Cancer and Sigmoid Diverticulosis, sponsored by Nantes University Hospital. Completed at 4 sites in France. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2026-09-01.
Sponsored by Nantes University Hospital · Observational
The aim of this present study is to compare functional results and quality of life after sigmoidectomy for diverticulitis and sigmoid cancer.
Rectal resection surgery can lead to numerous complications in term of gastrointestinal results with onset of fecal incontinence or in contrast constipation, and in term of genitourinary results with occurrence of dysuria, erectile dysfunction, or vaginal dryness. The low anterior resection syndrome is defined by the occurrence after rectal resection, of gastrointestinal symptoms like fecal incontinence or stool evacuation difficulties, which affect quality of life, despite conservation of anal sphincter. This syndrome is now well known and used in many countries.
However, there is a lack of data concerning gastrointestinal functional results after sigmoid surgery whether it is for cancer or diverticulitis. Some studies highlighted symptoms persistence in many patients after sigmoidectomy. Lately, the LARS score was used after sigmoidectomy for cancer. This study reveals symptoms of low anterior resection syndrome for 41 % of patients. The correlation between rectal resection and sigmoidectomy could be explain by the resection of the upper part of rectum in case of sigmoidectomy.
The issue of genito-urinary disorders after sigmoidectomy are poorly researched. Previous studies demonstrate a higher risk of erectile disorders after pelvic surgery and especially for cancer.
Currently, there is a lack of data on functional results and quality of life for patients who are going into sigmoid surgery, whether for cancer or diverticulitis. The aim of this longitudinal study is to compare digestive functional outcome, genitourinary outcomes and quality of life in patients who undergo sigmoid resection for diverticulitis and cancer.
Patients suffered from sigmoid cancer or symptomatic diverticulitis
Exclusion Criteria :
Sigmoid resection surgery for patients who suffer from sigmoid cancer
Procedure: Sigmoidectomy
Sigmoid resection surgery for patients who suffer from symptomatic diverticulitis
Procedure: Sigmoidectomy
The sigmoid resection surgery, realized by laparoscopy or laparotomy, with anastomosis.
LARS score
To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence.
Time frame: At the visit of preoperative
LARS score
To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence.
Time frame: At the visit of one month
LARS score
To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence.
Time frame: At the visit of three months
LARS score
To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence.
Time frame: At the visit of six months
LARS score
To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence.
Time frame: At the visit of twelve months
Bristol stool chart
A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea.
Time frame: At the visit of preoperative
Bristol stool chart
A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea.
Time frame: At the visit of one month
Bristol stool chart
A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea.
Time frame: At the visit of three months
Bristol stool chart
A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea.
Time frame: At the visit of six months
Bristol stool chart
A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea.
Time frame: At the visit of twelve months
GIQLI
Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life.
Time frame: At the visit of preoperative
GIQLI
Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life.
Time frame: At the visit of one month
GIQLI
Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life.
Time frame: At the visit of three months
GIQLI
Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life.
Time frame: At the visit of six months
GIQLI
Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life.
Time frame: At the visit of twelve months
SF-36
General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability.
Time frame: At the visit of preoperative
SF-36
General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability.
Time frame: At the visit of one month
SF-36
General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability.
Time frame: At the visit of three months
SF-36
General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability.
Time frame: At the visit of six months
SF-36
General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability.
Time frame: At the visit of twelve months
FSFI
Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function.
Time frame: At the visit of preoperative
FSFI
Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function.
Time frame: At the visit of one month
FSFI
Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function.
Time frame: At the visit of three months
FSFI
Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function.
Time frame: At the visit of six months
FSFI
Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function.
Time frame: At the visit of twelve months
ICIQ-FLUTS
Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence.
Time frame: At the visit of preoperative
ICIQ-FLUTS
Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence.
Time frame: At the visit of one month
ICIQ-FLUTS
Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence.
Time frame: At the visit of three months
ICIQ-FLUTS
Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence.
Time frame: At the visit of six months
ICIQ-FLUTS
Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence.
Time frame: At the visit of twelve months
IPSS
Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function.
Time frame: At the visit of preoperative
IPSS
Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function.
Time frame: At the visit of one month
IPSS
Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function.
Time frame: At the visit of three months
IPSS
Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function.
Time frame: At the visit of six months
IPSS
Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function.
Time frame: At the visit of twelve months
IIEF5
Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function.
Time frame: At the visit of preoperative
IIEF5
Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function.
Time frame: At the visit of one month
IIEF5
Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function.
Time frame: At the visit of three months
IIEF5
Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function.
Time frame: At the visit of six months
IIEF5
Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function.
Time frame: At the visit of twelve months
Plan to share: No
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Nantes University Hospital