Disease Progression clinical trials
The registry lists 402 studies for Disease Progression across more than 10 countries. 112 are recruiting or about to start. 31 of them are mainly about Disease Progression (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Pathologic Complete Response: 585 studies, 183 open.
Get an email when these change. Save the Disease Progression studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (12) · National Cancer Institute (NCI) (11) · Assistance Publique - Hôpitaux de Paris (6) · Peking Union Medical College Hospital (5) · Mansoura University (5) · University of Zurich (5) · Radboud University Medical Center (5) · M.D. Anderson Cancer Center (5)
What is being tested here
Drugs under test in Disease Progression studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Colchicine | 2 | 0 | 2 |
| Capivasertib | 1 | 2 | 2 |
| Ublituximab | 1 | 0 | 2 |
| Rituximab | 1 | 0 | 1 |
| Immunoglobulins, Intravenous | 1 | 0 | 1 |
| Immunoglobulin G | 1 | 0 | 1 |
| Sacituzumab tirumotecan | 1 | 0 | 1 |
| Thioctic Acid | 1 | 0 | 1 |
| Regorafenib | 1 | 0 | 1 |
| Cemiplimab | 1 | 0 | 1 |
Drug classes tested here Antimitotic agents 3 open · Tyrosine kinase inhibitors (TKIs) 1 open · Immune checkpoint inhibitors 1 open · Proteasome inhibitors 5 · Reverse transcriptase inhibitors 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP) · Ferrer Internacional S.A.
- Nov 2026IPF Longitudinal Natural History Study · Assiut University
- Nov 2026The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action · Kaohsiung Medical University Chung-Ho Memorial Hospital
- Dec 2026Clinical Features, Current Treatment and Clinical Outcomes in Patients With INR-CAD: a Cohort Study · Peking Union Medical College Hospital
- Dec 2026A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies · RasCal Therapeutics, Inc.
- Dec 2026Combination of TATE and PD-1 Inhibitor in Liver Cancer · Teclison Ltd.
- Dec 2026Muco-active Agent Use and Clinical Outcomes After Lung Cancer Diagnosis in Chronic Obstructive Pulmonary Disease · Seoul National University
- Dec 2026The Norwegian World Health Organisation Labour Care Guide Trial (NORWEL) · Ostfold Hospital Trust
- Jan 2027Pembrolizumab Plus Autologous Dendritic Cell Vaccine in Patients with PD-L1 Negative Advanced Mesothelioma Who Have Failed Prior Therapies · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
- Jan 2027Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC · Ain Shams University
Who these studies take
Of the 74 Disease Progression studies recruiting now, 42 (57%) set no upper age limit and 16 (22%) stop at 75 or younger. 7 (9%) take children under 18. 3 (4%) are for women only and 2 (3%) for men only; 17 (23%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (5%) | 4 (5%) |
| 18 | 62 (84%) | 61 (82%) |
| 30 | 64 (86%) | 62 (84%) |
| 40 | 65 (88%) | 64 (86%) |
| 50 | 68 (92%) | 67 (91%) |
| 65 | 66 (89%) | 65 (88%) |
| 75 | 62 (84%) | 62 (84%) |
| 85 | 52 (70%) | 52 (70%) |
Across all 402 studies, recruiting or not: 18% stop at 75 or younger and 11% at 65; 20% take children; 5% are for women only and 2% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Disease Progression studies take
Of 108 observational studies under Disease Progression, half reached primary completion within 68 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 62 mo23–74 · 32 studies | — | — |
| Observational | 68 mo35–153 · 108 studies | — | 67 mo35–153 · 103 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
- LEANDIP: Lean Diabetes in Asian IndiansNov 5, 2026NCT07918170
- A Prospective Cohort Study of Multimodal Biomarkers and Progression From Mild Cognitive Impairment to DementiaOct 15, 2026NCT07876570
Studies
Recruiting first, then most recently updated. Showing 50 of 402. Browse all 402 → or search them.
- BLinatumomab and iNKT in Relapsed B-Cell ALLNot yet recruitingNCT07869368Phase 11 country
- LEANDIP: Lean Diabetes in Asian IndiansNot yet recruitingNCT07918170
- Clinical Trial of Avasopasem in Patients With Metastatic Hormone Receptor Positive Breast Cancer With Progression on a CDK 4/6 Inhibitor and Hormonal TherapyRecruitingNCT07137871Phase 11 country
- NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)RecruitingNCT023278971 country
- Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART)RecruitingNCT063061701 country
- Autoantibody Reduction Therapy for Progressive Idiopathic Pulmonary FibrosisNot yet recruitingNCT07674745Phase 21 country
- Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate CancerRecruitingNCT04692675Not applicable1 country
- A Prospective Cohort Study of Multimodal Biomarkers and Progression From Mild Cognitive Impairment to DementiaRecruitingNCT078765701 country
- Dynamic Changes and Risk Factors of Fibrosis and Steatosis Progression in Nonalcoholic Fatty Liver DiseaseRecruitingNCT036355411 country
- Multimodal Digital Biomarker Prediction of Acute Clinical DeteriorationEnrolling by invitationNCT078175501 country
- Colchicine Effect on Amyotrophic Lateral Sclerosis PatientsNot yet recruitingNCT07813858Phase 21 country
- Symptom Trajectory Approaches to ResearchNot yet recruitingNCT078048751 country
- Clinical Prediction Model for Disease Progression in Primary Membranous NephropathyNot yet recruitingNCT07785739
- TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic AtaxiasRecruitingNCT077986749 countries
- Sacituzumab Tirumotecan in Pts w/ NEPC After Progression on Prior ChemotherapyNot yet recruitingNCT07639086Phase 21 country
- Pulse Radiotherapy to Overcome Metastatic Immune System Evasion in Lung CancerRecruitingNCT06622174Phase 11 country
- AXIS MG Patient RegistryRecruitingNCT077610261 country
- Phase III Study to Evaluate the Safety, Efficacy, and Impact on Quality of Life of Capivasertib Alongside Standard-of-care Endocrine Treatment in Patients With HR+/HER2- Advanced Breast Cancer and Progression on Prior Endocrine-based TreatmentRecruitingNCT07281833Phase 33 countries
- Study on Clinical and Pathological Features of Primary Biliary Cholangitis and Risk Factors Related to Disease ProgressionNot yet recruitingNCT077338821 country
- Developing a Comprehensive Biomarker Panel for Monitoring Progression and Early Detection in ALS PatientsNot yet recruitingNCT077379772 countries
- IBD Biomarker Discovery and Validation PlatformRecruitingNCT076864061 country
- Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS StudyRecruitingNCT058512091 country
- Association Between Chronic Psychological Stress and Disease Course Outcomes in Pancreatic CancerRecruitingNCT075296261 country
- A Trial of RSC-1255 for Treatment of Patients With Advanced MalignanciesRecruitingNCT04678648Phase 11 country
- Prospective Multicenter Registry Study of Multiple System Atrophy in ChinaRecruitingNCT076440131 country
- A Multicenter Registry-Based Study Across the Spectrum of Degenerative Cervical MyelopathyNot yet recruitingNCT076416991 country
- Assessment of Retreatment With Lutathera® in Patients With New Progression of Intestinal Well-differenciated NETRecruitingNCT04954820Phase 21 country
- Construction of a Cohort of Elderly Patients With Atrial Fibrillation in Rural ChinaRecruitingNCT076110841 country
- Association Between Irrigation Fluid Absorption and Perioperative cfDNA Dynamics After TURBTRecruitingNCT075894131 country
- Screening, Characterization, and Longitudinal Follow-up of Patients With Cardiac AmyloidosisNot yet recruitingNCT075774661 country
- Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLCNot yet recruitingNCT07574684Phase 2
- First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 AstrocytomaRecruitingNCT07560865Phase 11 country
- Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With CancerRecruitingNCT05297734Not applicable1 country
- Hypertension Explored in Long-term Postpartum Follow-up in Later LifeRecruitingNCT061870121 country
- Combination of TATE and PD-1 Inhibitor in Liver CancerRecruitingNCT03259867Phase 21 country
- Tumor Budding and T1 Substaging in Urothelial Bladder CancerNot yet recruitingNCT07529639
- Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALSRecruitingNCT052040171 country
- Standardized Italian netwoRk Enrolling iNdividuals With Islet-AutoantibodiesNot yet recruitingNCT075033661 country
- Regorafenib After Treatment Failure of First Line Immune Checkpoint Inhibitor Treatment in Advanced Hepatocellular Carcinoma PatientsNot yet recruitingNCT07514455Phase 21 country
- Transformative Research in Diabetic NephropathyRecruitingNCT029869841 country
- A Clinical Trial to Evaluate EDV Nanocell Therapy With Gemcitabine and Nab-paclitaxel in Pancreatic CancerRecruitingNCT07049055Phase 1/21 country
- Evolution of Lesions in Repeated Biparametric Prostate Magnetic Resonance ImagingRecruitingNCT07369570Not applicable1 country
- FDG-PET/CT vs. CT for Monitoring Metastatic Breast CancerRecruitingNCT06877949Not applicable3 countries
- Circadian Rhythm and Other Factors in Memory Clinic PatientsRecruitingNCT059777121 country
- OPEN-IPF: Observational Prediction modEl for cliNical Outcomes in Idiopathic Pulmonary FibrosisNot yet recruitingNCT07404423
- Effects of Ublituximab on Motor Functions in Multiple SclerosisRecruitingNCT06629428Early Phase 11 country
- MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)RecruitingNCT073622251 country
- Dimensional and Developmental Profiles of Psychosis in Children and AdolescentsRecruitingNCT04370730Not applicable1 country
- Association of Nutrition and T Cell Immune Activity With Disease Progression in Nontuberculous Mycobacterial Pulmonary DiseaseNot yet recruitingNCT073637981 country
- Evolution of Endometriosis Lesions Followed by Ultrasound and Quality of Life of Patients: Factors That Influence Disease Progression in a Prospective CohortNot yet recruitingNCT072829901 country