DrugBiological
Sacituzumab tirumotecan clinical trials
Also written SKB264 and MK-2870.
- studies test it
- 95
- open now
- 79
- in phase 3
- 27
- first study started
- 2020
Keep track of what changes. Save the sacituzumab tirumotecan studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
- sac-TMT
- 21
Combined with it in one product
Studies by the year they started
91 studies that test it; most in 2026 (43); 4 more planned to start later
| Year | Studies |
|---|---|
| 2020 | 1 |
| 2022 | 2 |
| 2023 | 7 |
| 2024 | 13 |
| 2025 | 25 |
| 2026 | 43 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 7
- Phase 2
- 66
- Phase 3
- 27
- No phase
- 1
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 39 · Other 56
Merck Sharp & Dohme LLC (22) · Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (15) · Fudan University (7) · Tianjin Medical University Cancer Institute and Hospital (6) · Klus Pharma Inc. (2) · M.D. Anderson Cancer Center (2) · Latin American Cooperative Oncology Group (2) · Guangdong Association of Clinical Trials (2)
Often tested with
Tested in the same studies.
Pembrolizumab (7) · Toripalimab (5) · Tagitanlimab (5) · Anlotinib (4) · Anti-PD-1/Anti-VEGF-A Bispecific Antibody CR-001 (3) · Paclitaxel (3) · Bevacizumab (2) · Osimertinib (2)
Studies
Open first, then newest update. How each study uses sacituzumab tirumotecan is read from its arms, and is right about nine times in ten.
Testing it · 95
- A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07419295Written as Sacituzumab tirumotecan
- Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]RecruitingPhase 3Merck Sharp & Dohme LLCNCT06422143Written as sac-TMT
- A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06637423Written as Sacituzumab tirumotecan
- A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06312137Written as Sacituzumab tirumotecan
- Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06170788Written as Sacituzumab tirumotecan
- A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010)RecruitingPhase 2Merck Sharp & Dohme LLCNCT07785609Written as Sacituzumab tirumotecan
- Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06393374Written as Sacituzumab tirumotecan
- A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06312176Written as Sacituzumab tirumotecan
- A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06841354Written as Sacituzumab tirumotecan
- A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06966700Written as Sacituzumab tirumotecan
- A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06824467Written as Sacituzumab tirumotecan
- A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06952504Written as Sacituzumab Tirumotecan
- A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07216703Written as Sacituzumab Tirumotecan
- A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07318558Written as Sacituzumab tirumotecan
- A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT05319730Written as Sacituzumab tirumotecan
- A Prospective Study of Sacituzumab Tirumotecan Plus Pembrolizumab for Advanced Biliary Tract CancerRecruitingPhase 2Haitao Zhao, MDNCT07850791Written as Sacituzumab Tirumotecan (SKB264)
- Phase 2 Trial Of Sacituzumab Tirumotecan For Treatment Of Refractory Metastatic Or Unresectable Squamous Cell Carcinoma Of The Anus/RectumNot yet recruitingPhase 2M.D. Anderson Cancer CenterNCT07511023Written as Sacituzumab Tirumotecan
- A Phase II Study of SKB264 + SKB118 in Nsq-NSCLC After EGFR-TKI FailureNot yet recruitingPhase 2Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.NCT07854509Written as SKB264+SKB118
- Phase II Trial of Sacituzumab Tirumotecan in Patients With SMARCB1-Deficient Renal Medullary CarcinomaRecruitingPhase 2M.D. Anderson Cancer CenterNCT07438626Written as Sacituzumab tirumotecan
- A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) and Pembrolizumab (MK-3475A) in Participants With Bladder Cancer (MK-2870-055)Not yet recruitingPhase 3Merck Sharp & Dohme LLCNCT07829783Written as Sac-TMT
See all 95 studies that test sacituzumab tirumotecan →
Given in every arm · 13 — sacituzumab tirumotecan is usual care beside what is tested
- A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06428409Written as Sacituzumab tirumotecan
- Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06780111Written as Sacituzumab tirumotecan
- Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06469944Written as Sacituzumab Tirumotecan (sac-TMT)
- A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT07286149Written as Sacituzumab tirumotecan
- Sacituzumab Tirumotecan +/- Pembrolizumab in I/O Exposed Metastatic or Recurrent Ovarian Clear Cell CancerRecruitingPhase 2Tufts Medical CenterNCT07718854Written as Sacituzumab tirumotecan
- KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)RecruitingPhase 2Merck Sharp & Dohme LLCNCT07252739Written as Sacituzumab tirumotecan (sac-TMT)
- GB268 Monotherapy or Combination Therapy for Locally Advanced/Metastatic Breast Cancer (Phase Ib/Ⅱ)Not yet recruitingPhase 1/2Eddingpharm (Zhuhai) Co., Ltd.NCT07738341Written as Sacituzumab Tirumotecan
- SKB264 Combinatiton Therapy in Patients With Advanced or Metastatic Non-small Cell Lung Cancer.RecruitingPhase 2Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.NCT05351788Written as SKB264
- Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)Active, not recruitingPhase 2Merck Sharp & Dohme LLCNCT06788912Written as Sacituzumab tirumotecan
- Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)Active, not recruitingPhase 1Merck Sharp & Dohme LLCNCT06049212Written as Sacituzumab tirumotecan
- SKB264 +/- KL-A167 in Recurrent or Metastatic HER2-negative Breast CancerCompletedPhase 2Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.NCT05445908Written as SKB264
- A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)Active, not recruitingPhase 1/2Merck Sharp & Dohme LLCNCT06483334Written as Sacituzumab tirumotecan
- A Study of SKB264 (MK-2870; Sac-TMT) for the Treatment of Participants With Advanced or Metastatic Non-small Cell Lung Cancer (SKB264-II-04) (MK-2870-003)Active, not recruitingPhase 2Klus Pharma Inc.NCT05816252Written as SKB264
Codes
What other systems call sacituzumab tirumotecan · ClinicalTrials.gg INT014653
- UNII (FDA) 3DV5TD1VL3SACITUZUMAB TIRUMOTECANOne source FDA
- NCI Thesaurus C166409Sacituzumab TirumotecanOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | 3DV5TD1VL3 | SACITUZUMAB TIRUMOTECAN | One source FDA |
| NCI Thesaurus | C166409 | Sacituzumab Tirumotecan | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.