Pathologic Complete Response clinical trials
The registry lists 138 studies for Pathologic Complete Response across more than 10 countries. 57 are recruiting or about to start. 20 of them are mainly about Pathologic Complete Response (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Pathologic Complete Response studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Sixth Affiliated Hospital, Sun Yat-sen University (6) · Henan Cancer Hospital (4) · Tang-Du Hospital (3) · Assistance Publique - Hôpitaux de Paris (3) · The Netherlands Cancer Institute (3) · Fudan University (2) · Shanghai Pulmonary Hospital, Shanghai, China (2) · Centre Leon Berard (2)
What is being tested here
Drugs under test in Pathologic Complete Response studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Trastuzumab | 3 | 0 | 5 |
| Paclitaxel | 2 | 1 | 6 |
| Toripalimab | 2 | 0 | 3 |
| Trastuzumab rezetecan | 2 | 0 | 2 |
| Tretinoin | 2 | 0 | 2 |
| Pembrolizumab | 1 | 0 | 3 |
| Cyclophosphamide | 1 | 3 | 3 |
| Olaparib | 1 | 1 | 2 |
| Oxaliplatin | 1 | 1 | 2 |
| Albumin-Bound Paclitaxel | 1 | 0 | 2 |
Drug classes tested here Immune checkpoint inhibitors 7 open · Tyrosine kinase inhibitors (TKIs) 3 open · Antimitotic agents 2 open · Alkylating agents 1 open · PARP inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Nimotuzumab Combined With Toripalimab and Chemotherapy for Locally Advanced Tonsillar Cancer · Tang-Du Hospital
- Dec 2026Neoadjuvant Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer(CONTROL-01) · The Affiliated Hospital of Qingdao University
- Dec 2026Treatment Patterns and Survival Outcomes in High-Grade Osteosarcoma: A Multicenter Retrospective Study · MedPacto, Inc.
- Dec 2026Perioperative Systemic Therapies in Muscle-Invasive Bladder Cancer (GUARDIANS) · LMU Klinikum
- Dec 2026Node-Sparing Short-Course Radiotherapy (25 Gy/5 Fractions) Combined With Chemoimmunotherapy as Neoadjuvant Treatment for Locally Advanced Esophageal Squamous Cell Carcinoma:A Prospective Single-Arm, Phase II Study · Sixth Affiliated Hospital, Sun Yat-sen University
- Dec 2026Application of MRI Radiomics Features in Neoadjuvant Therapy of Head and Neck Squamous Cell Carcinoma · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Feb 2027Study of Pembrolizumab Following Surgery in Patients With Microsatellite Instability High (MSI-H) Solid Tumors · Memorial Sloan Kettering Cancer Center
- Feb 2027Surgery After Verifying Existing Disease in Locally Advanced Operable Lung Cancer: A Pilot Study · Centre hospitalier de l'Université de Montréal (CHUM)
- Apr 2027Chemoradiation and Consolidation Chemotherapy With or Without Oxaliplatin for Distal Rectal Cancer and Watch and Wait · Hospital Alemão Oswaldo Cruz
- Jun 2027Dynamic Multi-omics Integration Model to Predict Neoadjuvant Therapy Response in Locally Advanced Rectal Cancer · Sixth Affiliated Hospital, Sun Yat-sen University
Who these studies take
Of the 43 Pathologic Complete Response studies recruiting now, 22 (51%) set no upper age limit and 15 (35%) stop at 75 or younger. 4 (9%) take children under 18. 10 (23%) are for women only and 1 (2%) for men only; 1 (2%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (2%) | 1 (2%) |
| 18 | 38 (88%) | 31 (72%) |
| 30 | 40 (93%) | 32 (74%) |
| 40 | 41 (95%) | 32 (74%) |
| 50 | 41 (95%) | 32 (74%) |
| 65 | 41 (95%) | 32 (74%) |
| 75 | 34 (79%) | 28 (65%) |
| 85 | 21 (49%) | 17 (40%) |
Across all 138 studies, recruiting or not: 30% stop at 75 or younger and 8% at 65; 9% take children; 28% are for women only and 1% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 138. Browse all 138 → or search them.
- Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal CancerRecruitingNCT07472868Phase 31 country
- Treatment Patterns and Survival Outcomes in High-Grade Osteosarcoma: A Multicenter Retrospective StudyRecruitingNCT078783641 country
- Perioperative Systemic Therapies in Muscle-Invasive Bladder Cancer (GUARDIANS)RecruitingNCT078559261 country
- SHR-A1811 Versus Trastuzumab Plus Pertuzumab in ctDNA-Positive HER2-Positive Early Breast Cancer After Pathologic Complete ResponseNot yet recruitingNCT07856303Phase 21 country
- Lifestyle, Exercise, And Nutrition (LEAN) Trial on Pathologic Complete Response in TNBCRecruitingNCT07066189Not applicable1 country
- Perioperative Adebrelimab for Locally Advanced Cervical CancerNot yet recruitingNCT07811375Phase 21 country
- Node-Sparing Short-Course Radiotherapy (25 Gy/5 Fractions) Combined With Chemoimmunotherapy as Neoadjuvant Treatment for Locally Advanced Esophageal Squamous Cell Carcinoma:A Prospective Single-Arm, Phase II StudyRecruitingNCT07808853Phase 21 country
- Application of MRI Radiomics Features in Neoadjuvant Therapy of Head and Neck Squamous Cell CarcinomaRecruitingNCT067555671 country
- Response-adapted Postoperative Radiotherapy In Locally Advanced Head and Neck CancerNot yet recruitingNCT07780877Phase 21 country
- Surgery After Verifying Existing Disease in Locally Advanced Operable Lung Cancer: A Pilot StudyNot yet recruitingNCT06743555Phase 11 country
- Supervised Exercise During Neoadjuvant Chemotherapy for Breast CancerNot yet recruitingNCT07764341Not applicable1 country
- Oral Paclitaxel Solution With Immunotherapy and Concurrent SBRT as Neoadjuvant Treatment for Older Adults With NSCLCRecruitingNCT07754812Phase 41 country
- Penpulimab Combined With Chemotherapy for Patients With Locally Advanced Hypopharyngeal CarcinomaNot yet recruitingNCT07752394Phase 21 country
- Single-dose Preoperative Partial Breast Irradiation in Low-risk Breast Cancer PatientsRecruitingNCT05350722Not applicable2 countries
- Phase II Study Evaluating the Efficacy and Safety of the Combination of Tagraxofusp and Venetoclax in Treatment-naive Blastic Plasmacytoid Dendritic Cell Neoplasm PatientsRecruitingNCT07007052Phase 21 country
- Circulating cfDNA and HPV as Prognostic Biomarkers for First-Line Recurrent Metastatic Cervical CancerNot yet recruitingNCT07673211
- Intermittent Hypoxic Training as Neoadjuvant Therapy for Lung Squamous Cell CarcinomaNot yet recruitingNCT07618793Phase 21 country
- Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gynecologic, Breast, or Lung Solid TumorsRecruitingNCT07586826Phase 21 country
- Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gastrointestinal Solid TumorsRecruitingNCT07586813Phase 21 country
- I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast CancerRecruitingNCT01042379Phase 21 country
- Vebectotamab Vedotin Combined With Pucotelimab in the Treatment of Locally Advanced Laryngeal CarcinomaNot yet recruitingNCT07538206Phase 1/2
- Neoadjuvant Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer(CONTROL-01)RecruitingNCT06647680Phase 21 country
- Relugolix + Enzalutamide Study in High-Risk Prostate CancerRecruitingNCT06130995Phase 11 country
- Adebrelimab Combined With Chemotherapy for the Esophageal Squamous Cell CarcinomaRecruitingNCT07430579Not applicable1 country
- Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone SarcomasRecruitingNCT04055220Not applicable1 country
- NECTAR Study: Neoadjuvant Toripalimab + 9MW2821 for Local UTUCNot yet recruitingNCT07412171Phase 21 country
- Short-Course Radiotherapy Combined With Chemotherapy and Immunotherapy in Mid-Low Locally Advanced Rectal CancerNot yet recruitingNCT07397442Phase 21 country
- Nimotuzumab Combined With Toripalimab and Chemotherapy for Locally Advanced Tonsillar CancerRecruitingNCT07353723Phase 21 country
- T Cell Lymphoma -Stratified Therapy After Response to First-line Treatment-CRRecruitingNCT073538401 country
- 40.2Gy Versus 49.2Gy Radiotherapy in Low-Risk Target Volume for Chemosensitive Stage II Nasopharyngeal CarcinomaRecruitingNCT07328854Phase 31 country
- Reduced-dose Versus Conventional-dose Intensity-modulated Radiation Therapy for Locally Advanced Nasopharyngeal Carcinoma With Remission After Induction Chemotherapy and ImmunotherapyRecruitingNCT07328841Phase 31 country
- Dynamic Multi-omics Integration Model to Predict Neoadjuvant Therapy Response in Locally Advanced Rectal CancerRecruitingNCT063643711 country
- Neoadjuvant Chemotherapy Combined With Preoperative Radiotherapy for Locally Advanced Breast CancerNot yet recruitingNCT07164872Not applicable
- Efficacy of Neoadjuvant Subcutaneous Trastuzumab-Pertuzumab in Algerian Women With Locally Advanced HER2 Positive Breast CancerRecruitingNCT071661851 country
- Two-cycle and Three-cycle Induction Therapy With Modified TPF Regimen Combined and Camrelizumab for LANPCRecruitingNCT06811844Phase 21 country
- SHR-A1811 Plus Pertuzumab in the Neoadjuvant Treatment of HER2 Positive BCRecruitingNCT06927180Phase 21 country
- Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Stage III NSCLCRecruitingNCT061118073 countries
- Improving Response to Chemotherapy by Adding Physical Exercise in the Neoadjuvant Setting of Breast Cancer PatientsRecruitingNCT05976815Not applicable1 country
- DESCARTES: De-ESCAlation of RadioTherapy in Patients With Pathologic Complete rESponse to Neoadjuvant Systemic TherapyRecruitingNCT05416164Not applicable1 country
- Prognostic Analysis of Esophageal Cancer with Complete Pathological Response After Neoadjuvant TherapyNot yet recruitingNCT068894021 country
- Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for Acute Leukemia PatientsRecruitingNCT04314219Phase 31 country
- Comparing the Efficacy of Nab-PH+Pyrrolitinib and TCbHP in the Neoadjuvant Treatment of HER2 Positive BCRecruitingNCT05918328Phase 21 country
- Darsilide Combined With AI, Trastuzumab and Patuzumab in the Neoadjuvant Treatment of HR+/HER2+ Breast CancerRecruitingNCT06276868Phase 21 country
- Chemoradiation and Consolidation Chemotherapy With or Without Oxaliplatin for Distal Rectal Cancer and Watch and WaitRecruitingNCT05000697Not applicable3 countries
- Neoadjuvant Study With Pyrotinib and Trastuzumab and Abraxane in Patients With HER2-enriched Breast CancerRecruitingNCT05659056Phase 21 country
- The Prognostic Value of the Degree of Pathological Response of Induction Chemotherapy for NPCRecruitingNCT061826571 country
- Watch and Wait as Treatment for Patients With Rectal CancerRecruitingNCT03125343Not applicable1 country
- Multiparametric Quantitative MRI and Response to Neoadjuvant Radiotherapy for Soft-tissue SarcomaRecruitingNCT05684874Not applicable1 country
- Phase I Study of KN044 in Locally Advanced/Metastatic Solid TumorsRecruitingNCT04126590Phase 11 country
- Deep Learning Signature for Predicting Complete Pathological Response to Neoadjuvant Chemoimmunotherapy in Non-small Cell Lung CancerRecruitingNCT059257511 country