Digestive System Diseases clinical trials
The registry lists 406 studies for Digestive System Diseases across more than 10 countries. 79 are recruiting or about to start. 93 of them are mainly about Digestive System Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 189 narrower conditions too, such as Colorectal Neoplasms: 49,135 studies, 11,300 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Gilead Sciences (9) · Assistance Publique - Hôpitaux de Paris (6) · Exact Sciences Corporation (6) · M.D. Anderson Cancer Center (5) · Mirum Pharmaceuticals, Inc. (5) · Boston Scientific Corporation (4) · Hoffmann-La Roche (4) · Celgene (4)
What is being tested here
Drugs under test in Digestive System Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 3 open · Immune checkpoint inhibitors 3 open · Corticosteroids 1 open · Local anesthetics 1 open · Antimetabolites 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Study to Evaluate Tobevibart+Elebsiran in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide · Phase 3 · Vir Biotechnology, Inc.
- Jul 2027Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia · Phase 3 · GCS Ramsay Santé pour l'Enseignement et la Recherche
- Jul 2027Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery · Phase 3 · M.D. Anderson Cancer Center
- Oct 2027Domperidone in Treating Patients With Gastrointestinal Disorders · Phase 3 · M.D. Anderson Cancer Center
- Nov 2026A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection · Vir Biotechnology, Inc.
- Nov 2026Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients · Jiangxi Provincial Cancer Hospital
- Nov 2026Organoid Models of Hepatocellular Carcinoma · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Nov 2026Development and Prospective Validation of an AI-Based Diagnostic Model for Hepato-Pancreato-Biliary Diseases · Second Affiliated Hospital, School of Medicine, Zhejiang University
- Dec 2026Feasibility, Safety, and Potential Efficacy of Fecal Microbiota Transplantation (FMT) for Gastrointestinal Dysfunction in Children Following Hematopoietic Cell Transplant (HCT). · St. Jude Children's Research Hospital
- Dec 2026NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study · University of Nottingham
Who these studies take
Of the 58 Digestive System Diseases studies recruiting now, 24 (41%) set no upper age limit and 19 (33%) stop at 75 or younger. 17 (29%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 11 (19%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (19%) | 11 (19%) |
| 18 | 50 (86%) | 49 (84%) |
| 30 | 48 (83%) | 47 (81%) |
| 40 | 48 (83%) | 47 (81%) |
| 50 | 48 (83%) | 47 (81%) |
| 65 | 48 (83%) | 47 (81%) |
| 75 | 44 (76%) | 43 (74%) |
| 85 | 34 (59%) | 33 (57%) |
Across all 406 studies, recruiting or not: 36% stop at 75 or younger and 21% at 65; 21% take children; 2% are for women only and 1% for men only; 22% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Digestive System Diseases studies take
Of 42 phase 2 interventional studies under Digestive System Diseases, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 36 mo14–73 · 15 studies | — | — |
| Phase 2 | 31 mo20–55 · 42 studies | — | — |
| Phase 3 | 39 mo23–63 · 30 studies | — | — |
| Interventional, no phase | 21 mo6–57 · 77 studies | — | 29 mo11–63 · 63 studies |
| Observational | 43 mo18–102 · 56 studies | — | 46 mo18–114 · 45 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Effects of nVNS on Stress Reactivity in IBSNov 9, 2026NCT07926945
Studies
Recruiting first, then most recently updated. Showing 50 of 406. Browse all 406 → or search them.
- Effects of nVNS on Stress Reactivity in IBSNot yet recruitingNCT07926945Not applicable1 country
- Evaluation of Patients With Gastrointestinal DiseaseRecruitingNCT050413741 country
- A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in GermanyRecruitingNCT071023681 country
- Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe RegionsRecruitingNCT07654283Phase 26 countries
- A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASHRecruitingNCT06419374Phase 325 countries
- A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)RecruitingNCT06318169Phase 327 countries
- TheraSphere Japan Pre-Market StudyRecruitingNCT07377487Not applicable1 country
- Product Surveillance RegistryRecruitingNCT0152427641 countries
- Phase 2 Study of AHB-137 in HBeAg Negative Chronic Hepatitis B (CHB) Participants in Asia Pacific RegionRecruitingNCT07370207Phase 27 countries
- Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal CancerRecruitingNCT07222800Phase 317 countries
- Colonoscopy vs Stool Testing for Older Adults With Colon PolypsRecruitingNCT05612347Not applicable2 countries
- Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBSRecruitingNCT07197944Phase 314 countries
- Organoid Models of Hepatocellular CarcinomaRecruitingNCT06929845Not applicable1 country
- Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in ChildrenRecruitingNCT07222943Not applicable1 country
- Immune Responses to GlutenEnrolling by invitationNCT05209568Not applicable1 country
- Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal ResectionsRecruitingNCT07351071Not applicable1 country
- Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi AnalgesiaNot yet recruitingNCT07076641Phase 31 country
- Understanding New Cachexia Subtypes Through Observational Epidemiological ResearchRecruitingNCT077763531 country
- Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA TreatmentRecruitingNCT07213323Not applicable1 country
- Healthy Stool Volunteer Donors for Fecal Microbiota Transplantation TrialsRecruitingNCT06478823Not applicable1 country
- Development and Prospective Validation of an AI-Based Diagnostic Model for Hepato-Pancreato-Biliary DiseasesNot yet recruitingNCT07716670
- Feasibility, Safety, and Potential Efficacy of Fecal Microbiota Transplantation (FMT) for Gastrointestinal Dysfunction in Children Following Hematopoietic Cell Transplant (HCT).RecruitingNCT05664113Phase 11 country
- NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort StudyRecruitingNCT069567031 country
- The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe ItchingNot yet recruitingNCT07678645Phase 21 country
- Trans-nasal Endoscopy for Bariatric PatientsRecruitingNCT06200961Not applicable1 country
- Non-invasive Liver Screening Using FibroScan Device for Liver Disease Patients for the Steatosis/Fibrosis DatabaseRecruitingNCT028979081 country
- Study of Teprenone in the Treatment of Glucocorticoid-Induced Drug-Related Gastrointestinal InjuryNot yet recruitingNCT07654049Not applicable
- Intestinal OrganoidsRecruitingNCT05294107Not applicable1 country
- Prediction Model for MINS After Major Hepatobiliary SurgeryRecruitingNCT073350421 country
- Enabling Microbiomics- Driven Personalized NutritionEnrolling by invitationNCT066570011 country
- Advanced GastroInstestinal(GI) Surgery Training in Residency and Fellowship.RecruitingNCT074943181 country
- Evaluation of Hepato-Pancreato-BiliaryRecruitingNCT075654541 country
- Exclude or Expose in Irritable Bowel Syndrome: What Works for Whom and How?RecruitingNCT06940596Not applicable1 country
- Outcomes After Liver and Biliary Resection at a High-Volume CenterNot yet recruitingNCT075568351 country
- FMT for the Prevention of Infectious Complications in Patients With Moderately Severe and Severe Acute PancreatitisRecruitingNCT07464392Not applicable1 country
- AI-Driven Multimodal Imaging Integration for Diagnosis and Prognostication of Digestive System DiseasesRecruitingNCT070874181 country
- GpCRC Pediatric Gastroparesis Registry 2RecruitingNCT059813001 country
- Gastroparesis Registry 4RecruitingNCT058468021 country
- Study of Gastric Motility in Eosinophilic GastritisRecruitingNCT052294321 country
- Endoscopic Retrograde CholangiopancreatographyRecruitingNCT074901321 country
- Biochemical Response and Clinical Outcomes in Patients With PBCRecruitingNCT074497931 country
- Long-term Health Outcomes of Screen Detected and Potential Celiac Disease PatientsNot yet recruitingNCT073661511 country
- Video Tutorial and Oral Explanation Vs Oral Explanation Alone in Colonoscopy PreparationRecruitingNCT07355777Not applicable1 country
- Undiluted and Diluted NutritionNot yet recruitingNCT07352150Not applicable1 country
- Multidisciplinary Evaluation of Elderly Patients With Digestive Cancer (EPODIG-G)RecruitingNCT05066139Not applicable1 country
- Time to Post-operative Recovery of Serum Albumin as a Predictor of Outcome in Major Hepato Pancreato Biliary SurgeriesRecruitingNCT072630611 country
- Benefit of Transcutaneous Auricular Vagus Nerve Stimulation in Improving Quality of Life in First Line Treatment of Ovarian Cancer:RecruitingNCT06817161Phase 31 country
- Impact of Specific Oligomeric Supplementation in Oncologic Patients Undergoing Radiotherapy With Malnutrition or at Risk.Enrolling by invitationNCT070351321 country
- VALidation of Imaging-based Liver Biomarkers in PEDiatric PatientsRecruitingNCT072029101 country
- Efficacy and Safety of Bezafibrate 400 mg and Bezafibrate 200 mg as Adjunctive Treatments in Patients With Primary Biliary Cholangitis and Non-optimal Biochemical Response to Ursodeoxycholic Acid TherapyRecruitingNCT06443606Phase 31 country