Contracture clinical trials
The registry lists 79 studies for Contracture across more than 10 countries. 18 are recruiting or about to start. 55 of them are mainly about Contracture (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-21. Counting its narrower condition Dupuytren Contracture too: 151 studies, 35 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Riphah International University (4) · Endo Pharmaceuticals (3) · Ottawa Hospital Research Institute (3) · Bournemouth University (2) · Universitat Internacional de Catalunya (2) · University of Sao Paulo (2) · University of South Carolina (2) · Eva Ponten (2)
What is being tested here
Drugs under test in Contracture studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Azacitidine | 1 | 0 | 1 |
| Microbial Collagenase | 0 | 1 | 3 |
| Ketotifen | 0 | 0 | 1 |
| Xiapex | 0 | 1 | 1 |
| Oxymorphone | 0 | 0 | 1 |
| Botulinum toxin type A | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Dec 2026Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy · Shirley Ryan AbilityLab
- Jan 2027Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft · Universitas Sebelas Maret
Who these studies take
Of the 11 Contracture studies recruiting now, 3 (27%) set no upper age limit and 6 (55%) stop at 75 or younger. 3 (27%) take children under 18. 1 (9%) are for women only and 0 (0%) for men only; 2 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (18%) | 2 (18%) |
| 18 | 6 (55%) | 6 (55%) |
| 30 | 6 (55%) | 5 (45%) |
| 40 | 6 (55%) | 5 (45%) |
| 50 | 6 (55%) | 5 (45%) |
| 65 | 6 (55%) | 5 (45%) |
| 75 | 5 (45%) | 5 (45%) |
| 85 | 5 (45%) | 5 (45%) |
Across all 79 studies, recruiting or not: 51% stop at 75 or younger and 44% at 65; 24% take children; 8% are for women only and 10% for men only; 37% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Contracture studies take
Of 30 interventional studies with no phase under Contracture, half reached primary completion within 13 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 13 mo3–55 · 30 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin GraftOct 21, 2026NCT07885046
Studies
Recruiting first, then most recently updated. Showing 50 of 79. Browse all 79 → or search them.
- Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin GraftNot yet recruitingNCT07885046
- Study of GalaFLEX LITE™ Scaffold in Treatment of Capsular Contracture After Breast Implant AugmentationRecruitingNCT05945329Not applicable1 country
- Collagenase Injection for Contracture ManagementNot yet recruitingNCT07693556Early Phase 11 country
- Pseudomonas Aeruginosa Injection Combined With Polyvinylpyrrolidone-Iodine in Immediate Breast Reconstruction Surgery With ImplantsEnrolling by invitationNCT07460297Not applicable1 country
- Knee Flexionater to Avoid Motion Restoring SurgeryRecruitingNCT07454356Not applicable1 country
- Pilot Test of Caregiver Training Protocol for Brachial Plexus Birth InjuryRecruitingNCT06623357Not applicable1 country
- Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral PalsyEnrolling by invitationNCT06377085Phase 11 country
- Preoperative Serial Casting, Education, and Therapy for Dupuytren's ContractureNot yet recruitingNCT07024576Not applicable1 country
- Effectiveness of Rehabilitation Protocol in Patients With Shortened Posterior Leg MusclesRecruitingNCT06308380Not applicable1 country
- Glenohumeral Internal Rotation Deficit Among Professional AthletesRecruitingNCT064169171 country
- Early Intervention in Infants With Cerebral PalsyRecruitingNCT04250454Not applicable1 country
- Effect of Stretching Exercises on Plantar FasciaNot yet recruitingNCT06370741Not applicable
- Comparison of Dry Needling and IASTM on Hamstring Tightness in Posterior Pelvic TiltRecruitingNCT05931120Not applicable1 country
- Effect of Cryoneurolysis on Pain in Patients With Hand Contracture.RecruitingNCT060516561 country
- Determining the Reliability and Validity of a New Method for Measuring Upper Extremity Joint Range of Motion in Burn Patients Using a Tracking SystemNot yet recruitingNCT05881876
- Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's ContractureRecruitingNCT05440240Phase 41 country
- The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.RecruitingNCT055185651 country
- How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.RecruitingNCT055062281 country
- Pre-expanded Flap Versus Free Flap for Postburn Neck ContractureCompletedNCT07865689Not applicable1 country
- The Effect Of Myofascial Release Technique On Respiratory Parameters in Subjects With Short Hamstring MuscleCompletedNCT04193683Not applicable1 country
- Cyclops Syndrome After Anterior Cruciate Ligament ReconstructionTerminatedNCT05008731Phase 31 country
- Anterior Heel Wedge to Treat Flexion Contracture After Total Knee ArthroplastyCompletedNCT07620145Early Phase 11 country
- Trial Comparing Treatment Strategies in Dupuytren's ContractureActive, not recruitingNCT03192020Phase 41 country
- Dynamic Stretching vs. Foam Rolling: Effects on Hamstring Flexibility and Muscle Oxygenation in Tight HamstringsCompletedNCT07024017Not applicable1 country
- Prevention of Capsular Contracture in Postmastectomy Patients Undergoing Implant-based ReconstructionsActive, not recruitingNCT06785610Not applicable1 country
- A Prospective Trial of Virtual Home Rehabilitation After Burn InjuryCompletedNCT03475654Not applicable1 country
- Development, Validation and Evaluation of the Feasibility of the Observational Risk Assessment of Contractures (Longitudinal Evaluation) Tool: The ORACLE StudyCompletedNCT060429071 country
- Effects of Paraffin Wax Therapy vs METs in Post Burn Hand ContracturesCompletedNCT06198062Not applicable1 country
- Sonographic Study of Hip Joint in Hockey PlayersCompletedNCT057884191 country
- Extracorporeal Shockwave Therapy vs Mesotherapy in the Treatment of Myofascial Pain Syndrome: a Case-control StudyCompletedNCT06246591Not applicable1 country
- Neurodynamics vs. Stretching in Soccer Players With Short Hamstring SyndromeCompletedNCT05866913Not applicable1 country
- Effect of Mobilization With Movement on Weight Bearing Ankle Dorsiflexion Range of MotionStatus unknownNCT05844072Not applicable1 country
- Immediate and 24-hour Effects of HyperVolt, Body Tempering, and Cupping Compared to Stretching on Hamstring FlexibilityStatus unknownNCT05793242Not applicable1 country
- High Doses of Total End Range Time Offer Better Results Than Low Doses Treating Proximal Interphalangeal Joint StiffnessCompletedNCT05625451Not applicable1 country
- Reducing Recurrent Knee Flexion Contracture by Correcting Leg Length Discrepancy After Total Knee Arthroplasty for OACompletedNCT02861521Not applicable1 country
- Elastography and Thermography Plantar Fasciopathy Assessment After Radiofrequency Stimulation in a Sporty PopulationStatus unknownNCT05460117Not applicable1 country
- Novel Splinting Technique Using 3D ModelsStatus unknownNCT05351060Not applicable1 country
- Percutaneous Microelectrolysis in Agility, Joint Range and StrengthCompletedNCT04334772Not applicable1 country
- Functional DN for Shortened HS MuscleCompletedNCT04668092Not applicable1 country
- Pilot Study of Azficel-T for the Treatment of Restrictive Burn ScarsTerminatedNCT01858753Phase 21 country
- BOND Study: the Benefit Of Night Splinting in Dupuytrens'WithdrawnNCT03031080Not applicable1 country
- Mulligan's Bent Leg Raise Technique in Healthy FemalesCompletedNCT04716205Not applicable1 country
- Effects of Diacutaneous Fibrolysis on Flexibility and Active Neuromuscular ResponseStatus unknownNCT04827082Not applicable1 country
- Effect of Low Amplitude Vibration Therapy on Flexibility of Hamstring Muscle in Athletes of PakistanCompletedNCT04784741Not applicable1 country
- Effects of Diacutaneous Fibrolysis on Passive Neuromuscular ResponseStatus unknownNCT04778293Not applicable1 country
- Evaluation of the Immediate Effect and Safety of DMA™ Novel Muscle Stimulation TechnologyCompletedNCT04296201Not applicable1 country
- Gait Asymmetry Assessed Using Portable Gait Analysis SystemCompletedNCT024891881 country
- Classic and Sham Massage on Psychological and Physical Functional Variables in AthletesCompletedNCT03178604Not applicable1 country
- Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of ConsciousnessCompletedNCT03008486Phase 21 country
- Immediate Effects of Superficial Heat Associated With Elongation in the Posttraumatic Elbow ContractureCompletedNCT03179098Not applicable1 country