BiologicalDrug
Microbial Collagenase clinical trials
Also written Xiaflex, Collagenase Clostridium Histolyticum, AA4500 and EN3835.
Includes 4 studies of Xiapex.
Keep track of what changes. Save the Microbial Collagenase studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
70 studies that test it; most in 2010 (9)
| Year | Studies |
|---|---|
| 2003 | 1 |
| 2007 | 5 |
| 2008 | 1 |
| 2010 | 9 |
| 2011 | 6 |
| 2012 | 7 |
| 2013 | 3 |
| 2014 | 2 |
| 2015 | 1 |
| 2016 | 6 |
| 2017 | 2 |
| 2018 | 7 |
| 2019 | 4 |
| 2020 | 4 |
| 2021 | 3 |
| 2022 | 2 |
| 2023 | 3 |
| 2024 | 2 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 50 · Other 20
Endo Pharmaceuticals (33) · Endo USA Inc., a Keenova Therapeutics Company (5) · Healthpoint (4) · Charitable Union for the Research and Education of Peyronie's Disease (3) · Smith & Nephew, Inc. (3) · Indiana Hand to Shoulder Center (2) · University of Miami (1) · Tampere University (1)
Often tested with
Tested in the same studies.
Studies
Open first, then newest update. How each study uses Microbial Collagenase is read from its arms, and is right about nine times in ten.
Testing it · 70
- Study to Assess the Long-term Safety of KN3835 in the Treatment and Retreatment of Flexible/Semi-Flexible Hammertoe (HMT)Not yet recruitingPhase 3Endo USA Inc., a Keenova Therapeutics CompanyNCT07846280Written as KN3835
- Study to Assess KN3835 in the Treatment of Flexible/Semi-Flexible Hammertoe (HMT)RecruitingPhase 3Endo USA Inc., a Keenova Therapeutics CompanyNCT07759362Written as KN3835
- Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)CompletedPhase 3Endo USA Inc., a Keenova Therapeutics CompanyNCT06151197Written as EN3835
- Delayed Dose Collagenase Clostridium Histolyticum (CCH) Protocol for Men With Peyronie's DiseaseActive, not recruitingPhase 4Charitable Union for the Research and Education of Peyronie's DiseaseNCT06649539Written as Collagenase Clostridium Histolyticum
- Investigation of Surgery, Collagenase, and Restorex for the Improvement of Peyronie'sActive, not recruitingPhase 4Charitable Union for the Research and Education of Peyronie's DiseaseNCT04786106Written as Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex] (CCH)
- Efficacy of a Novel CCH Protocol for PD Among Prior Non-respondersCompletedPhase 4Charitable Union for the Research and Education of Peyronie's DiseaseNCT05108558Written as CCH administration
- Safety and Efficacy of Collagenase Clostridium Histolyticum After Prior Intralesional PRP for Peyronie's DiseaseActive, not recruitingPhase 4University of MiamiNCT05777031Written as Collagenase Clostridium Histolyticum (CCH)
- Trial Comparing Treatment Strategies in Dupuytren's ContractureActive, not recruitingPhase 4Tampere UniversityNCT03192020Written as Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex]
- Efficacy, Safety, and Tolerability, of EN3835 vs Placebo in the Treatment of Plantar FibromatosisCompletedPhase 2Endo USA Inc., a Keenova Therapeutics CompanyNCT05152173Written as EN3835
- A Study to Assess Collagenase Clostridium Histolyticum (CCH) in the Treatment of Plantar Fasciitis (PFA)CompletedPhase 2Endo USA Inc., a Keenova Therapeutics CompanyNCT06169319Written as Collagenase Clostridium Histolyticum (CCH)
- Fasciectomy vs Collagenase Injection in Recurrent Dupuytren DiseaseActive, not recruitingPhase 4Region SkaneNCT03406338Written as Collagenase Clostridium Histolyticum
- Long-Term Safety, Efficacy, and Durability of EN3835 in the Treatment and Retreatment of Plantar FibromatosisCompletedPhase 3Endo PharmaceuticalsNCT05254457Written as EN3835
- Effectiveness of Splinting After Collagenase InjectionCompletedPhase 3Foundation for Orthopaedic Research and EducationNCT04874870Written as Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex]
- Clostridium Histolyticum Collagenase Injection for Urethral DiseaseCompletedPhase 2University of South FloridaNCT02948842Written as Clostridium Histolyticum Collagenase
- Focused Shock Wave Therapy Outcomes in Peyronie's Disease and Erectile DysfunctionWithdrawnNot applicableMayo ClinicNCT05646602Written as Collagenase Clostridium Histolyticum
- Safety and Efficacy of EN3835 in Participants With Frozen ShoulderCompletedPhase 2Endo PharmaceuticalsNCT04496167Written as EN3835
- Long-Term Study of EN3835 (CCH-aaes) in Edematous Fibrosclerotic Panniculopathy (Cellulite)CompletedPhase 3Endo PharmaceuticalsNCT03526549Written as CCH-aaes
- Injection Techniques of Collagenase Clostridium Histolyticum (CCH) for the Treatment of EFP (Cellulite)CompletedPhase 2Endo PharmaceuticalsNCT03632993Written as collagenase clostridium histolyticum (CCH)
- Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult FemalesCompletedPhase 4LuxurgeryNCT05309525Written as Collagenase Clostridium Histolyticum-Aaes
- CCH Treatment of Cellulite in the Presence of Dermal Laxity With Comparison Between Two (2) Different Injection TechniquesCompletedPhase 2Endo PharmaceuticalsNCT04580303Written as collagenase clostridium histolyticum
See all 70 studies that test Microbial Collagenase →
Given in every arm · 3 — Microbial Collagenase is usual care beside what is tested
- Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's DiseaseRecruitingNot applicableMayo ClinicNCT06065436Written as Collagenase Clostridium Histolyticum
- Study of Different Interventions to Reduce Bruising Following CCH-Aaes Treatment for Cellulite of the ButtocksCompletedPhase 2Endo PharmaceuticalsNCT05419505Written as CCH-aaes
- An Open-label Study to Assess the Safety and Effectiveness of AA4500 in Combination With the ErecAid® Esteem® Manual Vacuum Therapy System in Treating Men With Peyronie's DiseaseCompletedPhase 3Endo PharmaceuticalsNCT02267460Written as AA4500
As the comparator · 1 — what is tested is compared with Microbial Collagenase
Codes
What other systems call Microbial Collagenase · ClinicalTrials.gg INT007238
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D003012 | Microbial Collagenase | One source ClinicalTrials.gov |
| RxNorm | 898492 | — | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.