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Not yet recruitingNCT07885046Updated Oct 21, 2026

Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft

An observational study in Joint Contracture, Contracture and Cicatrix, sponsored by Universitas Sebelas Maret. Not yet recruiting. Per ClinicalTrials.gov, last updated 2026-10-21.

Sponsored by Universitas Sebelas Maret · Observational

Updated Oct 21, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
300
Sex
All
01

Study summary

The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG).

A joint contracture is a tightening of scar tissue, most often after a deep burn, that limits how far a joint can move. Surgery can release the tight scar, but the contracture may return over time. Z-plasty rearranges nearby skin to lengthen the scar, while FTSG covers the released area with full-thickness skin taken from another part of the body. Previous studies have shown conflicting results about which technique has a lower risk of the contracture returning.

This study will review the medical records of patients who had contracture release surgery of the shoulder, elbow, wrist/hand, hip, knee, or ankle at Dr. Moewardi General Hospital, Surakarta, Indonesia, between 2016 and 2026. No new treatment or procedure will be given to patients, and all patient information will be kept anonymous.

The study hypothesis is that the rate of contracture recurrence differs between patients treated with Z-plasty and those treated with FTSG. The results may help surgeons choose the most suitable technique to reduce the risk of recurrence and improve patients' movement and quality of life.

Read the detailed description

Background Deep (full-thickness) burns over joints frequently lead to scar contractures that restrict range of motion (ROM), impair function and independence in daily activities, and reduce quality of life. Approximately one-third of burn patients have at least one contracture at hospital discharge. Despite surgical release, recurrence remains a clinical problem, with a pooled recurrence rate of about 10% reported for hand burn contractures. Z-plasty (local transposition flaps that lengthen the scar axis without donor tissue) and full-thickness skin graft (FTSG; coverage of the post-release defect with full-thickness skin from a donor site) are the two most commonly used techniques for releasing extremity contractures. Comparative evidence on recurrence is inconsistent: some studies report lower recurrence after Z-plasty and others report no significant difference. This variation may reflect differences in anatomical site, contracture morphology (linear band versus broad planar defect), burn severity, operative technique, rehabilitation adherence, and length of follow-up. Evidence specific to extremity joint contractures remains limited.

Objectives The primary objective is to compare the recurrence rate of extremity joint contracture after surgical excision/release with Z-plasty versus FTSG. Secondary objectives are to describe the demographic and clinical characteristics of patients in each group, to determine the recurrence rate within each group, and to identify factors associated with contracture recurrence.

Study Design This is a single-center, observational, analytic, retrospective cohort study based on review of existing medical records. Patients are grouped according to the closure technique documented in the operative report (Z-plasty alone or FTSG alone). Treatment allocation was determined by routine clinical care; no intervention is assigned or administered as part of this study.

Setting and Study Period Department of Plastic, Reconstructive and Aesthetic Surgery, Dr. Moewardi General Hospital / Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia. Medical records from 2016 to 2026 will be reviewed. Data collection and analysis are planned for July to November 2026.

Sampling Total (consecutive) sampling will be used: all patients meeting the eligibility criteria during the study period will be included, given the limited number of cases at a single institution. No formal a priori sample size calculation is performed.

Variables The exposure is the surgical technique (Z-plasty or FTSG). The outcome is contracture recurrence, defined as loss of the corrected ROM or development of a tethering scar band requiring revision, assessed by goniometric evaluation at least 6 to 12 months postoperatively. Potential confounders recorded include age, anatomical joint involved, depth of the initial burn, duration of follow-up, adherence to postoperative rehabilitation (physiotherapy, splinting, pressure garments), and comorbidities such as diabetes mellitus.

Data Collection and Management Data will be abstracted from medical records using a standardized, investigator-designed data collection form covering de-identified patient characteristics, clinical characteristics, operative technique, pre- and postoperative ROM, and recurrence status at the last recorded follow-up. Data will be verified and cleaned for completeness and internal consistency before analysis. Patients with incomplete records or loss to follow-up before the minimum recurrence-assessment period will be excluded, so the primary analysis will be a complete-case analysis.

Statistical Analysis Descriptive (univariate) statistics will summarize participant characteristics. Recurrence proportions between the Z-plasty and FTSG groups will be compared using the chi-square test, or Fisher's exact test when any expected cell count is less than 5. If appropriate, multivariable logistic regression will be performed to adjust for potential confounders. Statistical significance is set at p \< 0.05.

Ethics The study will be submitted for approval to the Health Research Ethics Committee of Dr. Moewardi General Hospital before data collection. Only secondary data from medical records are used, no direct intervention involves participants, and all data will be anonymized to protect patient confidentiality in accordance with Indonesian medical records regulations.

02

Conditions studied

  • Joint Contracture
  • Contracture
  • Cicatrix
  • Burn Scar Contractures

Keywords

  • joint contracture
  • z-plasty
  • FTSG
  • Contracture Release
  • Contracture Recurrence
03

In context

Contracture

152 studies on the registry are indexed under Contracture; 22 are open to participants now.

This study's planned enrollment of 300 is above the median of 110 across 36 observational studies indexed under Contracture.

Browse Contracture studies →

Lead sponsor

Universitas Sebelas Maret is the lead sponsor of 28 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients of all ages with extremity joint contracture, predominantly post-burn scar contracture, who underwent surgical contracture release with either Z-plasty or full-thickness skin graft at the Department of Plastic, Reconstructive and Aesthetic Surgery, Dr. Moewardi General Hospital, a tertiary referral hospital in Surakarta, Indonesia, between 2016 and 2026. Participants are identified retrospectively from hospital medical records.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients diagnosed with joint contracture of the extremities (shoulder, elbow, wrist/hand, hip, knee, or ankle)
  • Underwent surgical excision/release of the contracture using either Z-plasty or full-thickness skin graft (FTSG) as the sole closure technique at Dr. Moewardi General Hospital between 2016 and 2026
  • Complete medical records, including preoperative data, operative report, and postoperative follow-up records of at least 6 months

Exclusion criteria

Exclusion Criteria:

  • Contracture of non-burn etiology not comparable to post-burn contracture (e.g., congenital or purely neurogenic contracture)
  • Combined surgical techniques in a single procedure (e.g., Z-plasty combined with skin graft) that prevent clear group allocation
  • Incomplete or missing medical records, or loss to follow-up before the minimum recurrence-assessment period
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
300 participants (estimated)
Patient registry
No

Groups and cohorts

  • Z-Plasty

    Patients with extremity joint contracture (shoulder, elbow, wrist/hand, hip, knee, or ankle) who underwent surgical excision/release of the contracture with Z-plasty as the sole closure technique at Dr. Moewardi General Hospital between 2016 and 2026. Z-plasty involves transposition of two opposing triangular local flaps to lengthen the scar axis and reorient the scar without donor tissue. Data are obtained retrospectively from medical records; the procedure was performed as part of routine clinical care and was not assigned by the study.

    Procedure: Z-Plasty

  • Full-Thickness Skin Graft (FTSG)

    Patients with extremity joint contracture (shoulder, elbow, wrist/hand, hip, knee, or ankle) who underwent surgical excision/release of the contracture with full-thickness skin graft (FTSG) as the sole closure technique at Dr. Moewardi General Hospital between 2016 and 2026. FTSG involves covering the post-release defect with a graft containing the epidermis and full dermis harvested from a donor site. Data are obtained retrospectively from medical records; the procedure was performed as part of routine clinical care and was not assigned by the study.

    Procedure: Full-Thickness Skin Graft

Interventions

  • ProcedureZ-Plasty

    Surgical release of extremity joint contracture using Z-plasty as the sole closure technique. After incision/excision of the contracted scar band, two opposing triangular local flaps are transposed to lengthen the scar axis and reorient the scar along relaxed skin tension lines, without the need for donor-site tissue. Performed as part of routine clinical care; not assigned by the study.

  • ProcedureFull-Thickness Skin Graft

    Surgical release of extremity joint contracture by excision of the contracted scar, followed by coverage of the resulting defect with a full-thickness skin graft (epidermis and entire dermis) harvested from a donor site, used as the sole closure technique without combined local flap transposition. Performed as part of routine clinical care; not assigned by the study.

06

What researchers measure

Primary outcomes

  1. Rate of Contracture Recurrence

    Proportion of participants with contracture recurrence in each group, defined as loss of the surgically corrected range of motion (ROM) or the development of a tethering scar band requiring revision surgery, as documented in medical records based on goniometric evaluation. Recurrence is recorded as a binary outcome (recurrence / no recurrence) and compared between the Z-plasty and FTSG groups.

    Time frame: At least 6 months after surgery (assessed at last recorded follow-up)

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No — Individual participant data will not be shared because the study uses retrospective medical record data from a single hospital, and sharing was not covered by the ethics approval (308/VII/HREC/2026) or by hospital medical record confidentiality regulations. Aggregate results will be reported in publications.

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Oct 2026; primary completion for Jan 2027, 2 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 13, 2026
First posted
Oct 21, 2026
StartEst.
Oct 13, 2026
Primary completionEst.
Jan 1, 2027
CompletionEst.
Jan 31, 2027
Last update
Oct 21, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Oct 21, 2026
Show all 1 update
  1. Oct 21, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07885046
Lead sponsor
Universitas Sebelas Maret
Responsible party
Naufal Helmi Musyaffa (Medical Student Researcher, Department of Plastic, Reconstructive and Aesthetic Surgery, Universitas Sebelas Maret) — Principal investigator
First posted
Oct 21, 2026
Start date
Oct 13, 2026 (estimated)
Primary completion
Jan 1, 2027 (estimated)
Completion
Jan 31, 2027 (estimated)
Last update
Oct 21, 2026

Study contacts

Naufal Helmi Musyaffa, MD
Contact
naufalhelmimusyaffa@gmail.com
+6282236363445
Almas Mirza Murastomo, MD., M.Ked.Klin., Sp.B.P.R.E.
study director · Universitas Sebelas Maret / Dr. Moewardi General Hospital
Naufal Helmi Musyaffa, MD
principal investigator · Universitas Sebelas Maret

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.

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