Bone Neoplasms clinical trials
The registry lists 258 studies for Bone Neoplasms across more than 10 countries. 68 are recruiting or about to start. 130 of them are mainly about Bone Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Paranasal Sinus Neoplasms: 318 studies, 86 open.
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Status
Who runs them
Istituto Ortopedico Rizzoli (11) · M.D. Anderson Cancer Center (10) · Hoffmann-La Roche (8) · InSightec (6) · Stanford University (5) · National Cancer Institute (NCI) (5) · Memorial Sloan Kettering Cancer Center (5) · Assiut University (4)
What is being tested here
Drugs under test in Bone Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Doxorubicin | 2 | 1 | 4 |
| Dinutuximab | 2 | 1 | 2 |
| Zanzalintinib | 2 | 0 | 2 |
| Cisplatin | 2 | 1 | 2 |
| Oncolytic HSV-1 R130 | 2 | 0 | 2 |
| Tetrachloroethane | 2 | 0 | 2 |
| Irinotecan | 1 | 0 | 3 |
| Gemcitabine | 1 | 0 | 3 |
| Regorafenib | 1 | 0 | 2 |
| Dotmp SM-153 | 1 | 0 | 2 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 5 open · Antimetabolites 2 open · Immune checkpoint inhibitors 5 · Alkylating agents 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Narlumosbartmab Combined With Neoadjuvant Chemotherapy in Bone-derived Malignancies With Osteolytic Lesions and Multinucleated Giant Cells · Peking University People's Hospital
- Nov 2026Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma · Memorial Sloan Kettering Cancer Center
- Dec 2026Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients · Universitaire Ziekenhuizen KU Leuven
- Dec 2026Stress and Anxiety Before Biopsy, After Biopsy Results, and During Treatment in Patients With Suspected Bone or Soft Tissue Cancer · Istanbul University
- Dec 2026Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors · University of Southern California
- Dec 2026Proximal Femur Reconstruction Following Resection of Primary Bone Tumors: Analysis of the Clinical and Radiographic Results · Costantino Errani
- Dec 2026Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery · Istituto Ortopedico Rizzoli
- Jan 2027U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures · Precision IO Group
- Jan 2027In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors · University of Southern California
- Feb 2027Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas · Memorial Sloan Kettering Cancer Center
Who these studies take
Of the 52 Bone Neoplasms studies recruiting now, 33 (63%) set no upper age limit and 13 (25%) stop at 75 or younger. 23 (44%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 12 (23%) | 12 (23%) |
| 18 | 49 (94%) | 49 (94%) |
| 30 | 51 (98%) | 51 (98%) |
| 40 | 48 (92%) | 48 (92%) |
| 50 | 47 (90%) | 47 (90%) |
| 65 | 45 (87%) | 45 (87%) |
| 75 | 45 (87%) | 45 (87%) |
| 85 | 38 (73%) | 38 (73%) |
Across all 258 studies, recruiting or not: 27% stop at 75 or younger and 20% at 65; 50% take children; 2% are for women only and 1% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Bone Neoplasms studies take
Of 20 phase 1 interventional studies under Bone Neoplasms, half reached primary completion within 51 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 51 mo34–108 · 20 studies | — | — |
| Interventional, no phase | 50 mo14–65 · 40 studies | — | 51 mo17–70 · 34 studies |
| Observational | 192 mo41–… · 37 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 258. Browse all 258 → or search them.
- Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary MetastasesRecruitingNCT03093909Phase 11 country
- Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root InvolvementRecruitingNCT07707024Not applicable1 country
- Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated ConditionsRecruitingNCT031602741 country
- Iscador® P (Mistletoe) Immunotherapy for Recurrent Resectable Osteogenic SarcomaRecruitingNCT05726383Phase 21 country
- Combination Immunotherapy Targeting SarcomasNot yet recruitingNCT04433221Phase 1/21 country
- Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting SarcomasNot yet recruitingNCT03356782Phase 1/21 country
- Medical Payment Case Management for Financial Toxicity in Patients With Primary Bone Tumors: A Randomized Controlled TrialRecruitingNCT07888244Not applicable1 country
- XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue SarcomaRecruitingNCT06571734Phase 21 country
- LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic OncologyEnrolling by invitationNCT03244020Phase 41 country
- Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors.Not yet recruitingNCT07853105Phase 1/21 country
- A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)RecruitingNCT07193550Phase 21 country
- Financial Toxicity in Patients With Resected Soft Tissue and Bone SarcomasRecruitingNCT072156111 country
- Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image GuidanceRecruitingNCT076361482 countries
- Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise Service (AYA-ONE): A Pilot InterventionRecruitingNCT07662239Not applicable1 country
- Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal MetastasesRecruitingNCT03965234Phase 1/21 country
- Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's LymphomaRecruitingNCT07514819Not applicable1 country
- A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation TherapyRecruitingNCT068598011 country
- Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With SarcomaRecruitingNCT064090131 country
- Stress and Anxiety Before Biopsy, After Biopsy Results, and During Treatment in Patients With Suspected Bone or Soft Tissue CancerRecruitingNCT077274341 country
- "Exercise Intervention to Increase Physical Activity in Young Sarcoma Survivors (Sport Ist Herzenssache)"Not yet recruitingNCT07729059Not applicable
- U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK ProceduresRecruitingNCT07325578Not applicable1 country
- Bone Cancer Surgery Prospective DatabaseNot yet recruitingNCT076691031 country
- The Effect of Acute Normovolemic Hemodilution in Bone Tumor SurgeryRecruitingNCT06459141Not applicable1 country
- Neoadjuvant Radiotherapy and Surgery for High-Risk Localized Ewing SarcomaNot yet recruitingNCT076204311 country
- EVERolimus and LenvAtinib Versus Everolimus for Bone SarcomaNot yet recruitingNCT07619950Phase 2
- Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone MetasRecruitingNCT05419518Phase 21 country
- Preoperative Immunonutrition in Patients With Bone and Soft Tissue SarcomasRecruitingNCT07609329Not applicable1 country
- Proximal Femur Reconstruction Following Resection of Primary Bone Tumors: Analysis of the Clinical and Radiographic ResultsRecruitingNCT064865061 country
- Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With SarcomaRecruitingNCT06129903Not applicable1 country
- Samarium Optimized for Long-lasting Analgesia in Cancerous End-stage Bone PainRecruitingNCT07197645Phase 11 country
- Treatment of Truncated ALK-positive Bone Cancer Using Crizotinib (Xalkori) or Alectinib (Alecensa)Not yet recruitingNCT07560410Phase 1/21 country
- Mg OSTEOCRETE Post-Treatment OutcomesRecruitingNCT067201421 country
- Assessment of Healing and Function After Reconstruction Surgery for Bone SarcomasRecruitingNCT034424651 country
- Effectiveness Of Radiofrequency Ablation And Stabilization In Metastatic Spine Lesions By Positron Emission Computed Tomography (PET-CT) ConfirmationRecruitingNCT067162941 country
- Assessment of the Functional Outcome and Quality of Life in Sarcoma PatientsRecruitingNCT05051059Not applicable1 country
- Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the BoneRecruitingNCT050332881 country
- Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas PatientsRecruitingNCT04698785Phase 21 country
- Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone SarcomasRecruitingNCT04055220Not applicable1 country
- An Electronic Health Record (EHR)-Based Comprehensive Bone and Soft Tissue Tumor RegistryRecruitingNCT026779611 country
- Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage SurgeryRecruitingNCT057796701 country
- Evaluation of Tumor Resection and Reconstruction With Prosthetic ImplantsNot yet recruitingNCT07337018
- The Effect of Preoperative Intravenous Ferric Derisomaltose and EPO and Tranexamic Acid in Patients With Preoperative Anemia or Iron Deficiency in Bone TumorNot yet recruitingNCT07314424Phase 4
- In Vivo Lung Perfusion for Pulmonary Metastases of SarcomaRecruitingNCT02811523Phase 11 country
- Efficacy of Pre-operative Prehabilitation in Patients With Limb SarcomaRecruitingNCT04515459Phase 21 country
- Radiotherapy Treatments for Neoplasms of the LimbsRecruitingNCT063352511 country
- Investigation Into the Safety and Efficacy of ICG-Labeled Fluorescence Imaging Technology in Guiding the Resection of Bone and Soft Tissue TumorsNot yet recruitingNCT069791151 country
- Definitive Radiation for High-Risk Spine MetastasesRecruitingNCT06165419Phase 21 country
- Tissue Expression of Krüppel-Like Factors 4 and 7 in Bone TumorsRecruitingNCT069358641 country
- A Substudy of the Effect of Acute Normovolemic Hemodilution in Bone Tumor SurgeryRecruitingNCT06881498Not applicable1 country
- Observational Study, for Quality Assessment, of Sarcoma in European and Latin American Multidisciplinary NETWORKRecruitingNCT041819708 countries