An observational study in Osteoarthritis, Knee and Bone Diseases, sponsored by Assiut University. Not yet recruiting. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-09-18.
Sponsored by Assiut University · Observational
This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.
Knee osteoarthritis involves microstructural alterations in subchondral and cortical bone. Conventional MRI has limitations in visualizing cortical bone due to short T2 relaxation times. Multi-echo fast field echo (mFFE) sequences can produce CT-like images of cortical bone without ionizing radiation.
This observational study will include patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis. All participants will undergo both mFFE MRI and CT of the knee. The accuracy of mFFE MRI in detecting cortical bone degenerative changes will be compared with CT as the reference standard.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 80 is below the median of 100 across 486 observational studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis attending the Diagnostic and Interventional Radiology Department at Assiut University Hospital.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients aged 40 years or older with knee osteoarthritis who will undergo both multi-echo fast field echo (mFFE) MRI and CT of the knee for comparison of cortical bone evaluation.
Diagnostic accuracy of mFFE MRI for cortical bone changes
Overall diagnostic accuracy percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
Time frame: Baseline
Sensitivity of mFFE MRI for cortical bone changes
Sensitivity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
Time frame: Baseline
Specificity of mFFE MRI for cortical bone changes
Specificity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
Time frame: Baseline
Detection of subchondral sclerosis
Number of cases in which mFFE MRI correctly identifies subchondral sclerosis compared with CT
Time frame: Baseline
Detection of osteophytes
Number of cases in which mFFE MRI correctly identifies osteophytes compared with CT
Time frame: Baseline
Detection of joint space narrowing
Number of cases in which mFFE MRI correctly identifies joint space narrowing compared with CT
Time frame: Baseline
Image quality score
Mean subjective image quality score of mFFE MRI for cortical bone visualization on a predefined scale from 1 to 5, with higher scores indicating better image quality
Time frame: Baseline
No study locations are listed for this record.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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