Blood Loss, Surgical clinical trials
The registry lists 213 studies for Blood Loss, Surgical across more than 10 countries. 40 are recruiting or about to start. 156 of them are mainly about Blood Loss, Surgical (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Who runs them
Assiut University (7) · HemoSonics LLC (6) · Bayer (4) · Cairo University (4) · CytoSorbents, Inc (3) · Egymedicalpedia (3) · GATT Technologies BV (3) · Ain Shams University (3)
What is being tested here
Drugs under test in Blood Loss, Surgical studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tranexamic Acid | 9 | 12 | 46 |
| Oxytocin | 1 | 0 | 6 |
| Dexmedetomidine | 1 | 1 | 3 |
| Carbetocin | 1 | 0 | 3 |
| Ascorbic Acid | 1 | 0 | 1 |
| Calcium Gluconate | 1 | 0 | 1 |
| Phenylephrine | 1 | 0 | 1 |
| Rocuronium | 1 | 0 | 1 |
| Misoprostol | 0 | 3 | 6 |
| Epinephrine | 0 | 1 | 4 |
Drug classes tested here Antifibrinolytics 9 open · Local anesthetics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027Tranexamic Acid in Adult Spinal Deformity Surgery · Phase 3 · Hospital for Special Surgery, New York
- Nov 2026Intraoperative Estimated Blood Loss, Blood Transfusion, and Postoperative Clinical Outcomes in Patients Undergoing Non Cardiac Surgery, Siriraj Hospital · Siriraj Hospital
- Nov 2026Delivering Transcutaneous Auricular Neurostimulation to Reduce Blood Loss During Dialysis AV Graft Placement Procedures · University Surgical Vascular
- Jan 2027Hemocoll, Avitene, or Bone Wax for Cancellous Bone Bleeding After Single-Ray Amputation · Adichunchanagiri Institute of Medical Sciences, B G Nagara
- Jan 2027Early Outcome of Simultaneous Bilateral Total Knee Replacement With and Without Tourniquet · Shifa International Hospital
- Feb 2027Patient Blood Management in Patients Scheduled for Cardiac Surgery · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Apr 2027Prevention of HEMOrhagic Risk in Upper MYOmeCTomy by Use of Misoprostol. · University Hospital, Clermont-Ferrand
- May 2027Study of the Hemorai Vysio Wearable Device for Monitoring Changes Related to Blood Loss in Patients During and After Surgery. · Hemorai Inc
- Jun 2027Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE · University of Maryland, Baltimore
- Aug 2027Opioid-Free Anesthesia in FESS: A Prospective ERAS Study · Filiz Kaya
Who these studies take
Of the 27 Blood Loss, Surgical studies recruiting now, 10 (37%) set no upper age limit and 14 (52%) stop at 75 or younger. 6 (22%) take children under 18. 7 (26%) are for women only and 0 (0%) for men only; 4 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (11%) | 3 (11%) |
| 18 | 24 (89%) | 17 (63%) |
| 30 | 24 (89%) | 17 (63%) |
| 40 | 24 (89%) | 17 (63%) |
| 50 | 20 (74%) | 17 (63%) |
| 65 | 18 (67%) | 16 (59%) |
| 75 | 15 (56%) | 13 (48%) |
| 85 | 12 (44%) | 10 (37%) |
Across all 213 studies, recruiting or not: 29% stop at 75 or younger and 23% at 65; 16% take children; 15% are for women only and <1% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Blood Loss, Surgical studies take
Of 24 phase 4 interventional studies under Blood Loss, Surgical, half reached primary completion within 12 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 4 | 12 mo8–25 · 24 studies | — | 12 mo8–25 · 24 studies |
| Interventional, no phase | 11 mo5–23 · 40 studies | — | 11 mo5–25 · 31 studies |
| Observational | 12 mo7–60 · 23 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Results posted2
- Oral and Intravenous Tranexamic Acid in Lumbar Spine SurgeryNov 10, 2026NCT03037515
- DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac SurgeryOct 26, 2026NCT03954314
Newly registered1
- Early Outcome of Simultaneous Bilateral Total Knee Replacement With and Without TourniquetOct 29, 2026NCT07905495
Studies
Recruiting first, then most recently updated. Showing 50 of 213. Browse all 213 → or search them.
- Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.RecruitingNCT07288489Phase 320 countries
- Early Outcome of Simultaneous Bilateral Total Knee Replacement With and Without TourniquetEnrolling by invitationNCT07905495Not applicable1 country
- Hemocoll, Avitene, or Bone Wax for Cancellous Bone Bleeding After Single-Ray AmputationRecruitingNCT07788846Not applicable1 country
- Tranexamic Acid to Reduce Blood Loss After Varus Derotation OsteotomyNot yet recruitingNCT07672158Phase 31 country
- Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority TrialRecruitingNCT07636421Phase 41 country
- Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing SinusoscopyNot yet recruitingNCT07866274Phase 2
- Study of the Hemorai Vysio Wearable Device for Monitoring Changes Related to Blood Loss in Patients During and After Surgery.Not yet recruitingNCT07826637Not applicable1 country
- DDAVP Effect by TEG6 in Cardiac SurgeryRecruitingNCT071799911 country
- Quantra QPlus in Pediatric Cardiovascular ProceduresNot yet recruitingNCT075972781 country
- Opioid-Free Anesthesia in FESS: A Prospective ERAS StudyRecruitingNCT078123891 country
- Patient Blood Management in Patients Scheduled for Cardiac SurgeryRecruitingNCT066371371 country
- Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBEEnrolling by invitationNCT064508341 country
- TEG Use in Children Undergoing Procedures With High Anticipated Blood LossNot yet recruitingNCT05379530Not applicable
- Prophylactic Intravenous Calcium Gluconate to Decrease Blood Loss at Time of Cesarean Delivery in Pregnant Patients at High Risk for Uterine AtonyRecruitingNCT07217899Phase 21 country
- The Efficacy of Carbitocin in Reduction of Blood Loss During MyomectomyNot yet recruitingNCT07721623Early Phase 1
- TEAPOT Study MultisiteRecruitingNCT07565753Early Phase 11 country
- Topical Tranexamic Acid to Reduce Blood Loss During Cesarean DeliveryRecruitingNCT07362992Early Phase 11 country
- Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement ProjectNot yet recruitingNCT076296481 country
- Phenylephrine Tumescence for Hemostasis in Surgery for Burn InjuryRecruitingNCT01731444Phase 11 country
- Delivering Transcutaneous Auricular Neurostimulation to Reduce Blood Loss During Dialysis AV Graft Placement ProceduresRecruitingNCT06647017Not applicable1 country
- Tranexamic Acid in Adult Spinal Deformity SurgeryRecruitingNCT03553186Phase 31 country
- TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot StudyRecruitingNCT06580509Early Phase 11 country
- PVI vs ESP Block for Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery.RecruitingNCT07550114Not applicable1 country
- Prevention of HEMOrhagic Risk in Upper MYOmeCTomy by Use of Misoprostol.RecruitingNCT06882824Not applicable1 country
- The Intraoperative Technical Errors of Robotic vs. Laparoscopic Radical Right HemiclectomyNot yet recruitingNCT07138859Not applicable1 country
- Enucleation of Pancreatic Tumor by Blocking Abdominal Trunk and Superior Mesenteric ArteryRecruitingNCT06164769Not applicable1 country
- To Compare the Effects of Oxytocin and Carbetocin on Intraoperative Hemodynamic Changes in Cesarean Section Surgeries.RecruitingNCT06956365Not applicable1 country
- Usability of Pericardial Flushing with the Haermonics Pure System After Cardiac SurgeryNot yet recruitingNCT06521164Not applicable
- Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding ScoreRecruitingNCT06725732Early Phase 11 country
- The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.RecruitingNCT06427707Phase 2/31 country
- Decreasing Postoperative Blood Loss and Seizures by Timing of Intravenous Tranexamic Acid 2 Pilot TrialNot yet recruitingNCT06622564Phase 31 country
- Effectiveness of a Intraoperative Blood Recovery System in Cardiovascular Surgery in BrazilRecruitingNCT06601582Not applicable1 country
- Role of TXA in Patients Undergoing Breast Free Flap ReconstructionRecruitingNCT06428682Phase 41 country
- Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizing Muscle RelaxantsRecruitingNCT06399445Phase 41 country
- B-lynch Transverse Compression SutureRecruitingNCT06359886Not applicable1 country
- Platelet Count and Function After Usage of Two Different Cell Saver Devices During Liver Transplant SurgeryNot yet recruitingNCT06357455Not applicable1 country
- Tranexamic Acid During Excisional Burn SurgeryRecruitingNCT05507983Phase 31 country
- Analysis of Intraoperative Bleeding Characteristics in Laparoscopic PancreaticoduodenectomyRecruitingNCT061286031 country
- Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal DeformationsRecruitingNCT04697498Not applicable1 country
- Extended Cold Stored Apheresis Platelets in Cardiac Surgery PatientsRecruitingNCT05220787Phase 1/21 country
- Oral and Intravenous Tranexamic Acid in Lumbar Spine SurgeryCompletedNCT03037515Phase 41 country
- Combined Intravenous and Irrigation Tranexamic Acid During Percutaneous NephrolithotomyCompletedNCT07582341Phase 41 country
- DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac SurgeryTerminatedNCT03954314Phase 36 countries
- Safe and Timely Antithrombotic Removal - Ticagrelor (STAR-T)CompletedNCT04976530Not applicable2 countries
- Safe and Timely Antithrombotic Removal (STAR) RegistryActive, not recruitingNCT050771246 countries
- Effect of Regional Anesthesia Techniques on Perioperative Blood Loss in Femoral Neck Fracture SurgeryCompletedNCT077020841 country
- Tranexamic Acid for Reduction of Transfusion in Abdominal SurgeryCompletedNCT06414031Phase 31 country
- A Phase III Study of Hemofence for Hemostasis in Patients With Uncontrolled Exudative Hemorrhage During Spinal Or Orthopedic SurgeryCompletedNCT07824024Phase 31 country
- Major Vascular Injuries in Elective Thoracic Surgery: A 10-Year Single-Center ExperienceCompletedNCT07100509
- Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus SurgeryCompletedNCT06848764Not applicable1 country