Astigmatism clinical trials
The registry lists 417 studies for Astigmatism across more than 10 countries. 50 are recruiting or about to start. 184 of them are mainly about Astigmatism (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
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Status
Who runs them
Alcon Research (51) · CooperVision International Limited (CVIL) (34) · Bausch & Lomb Incorporated (19) · Johnson & Johnson Vision Care, Inc. (16) · CooperVision, Inc. (9) · Beaver-Visitec International, Inc. (8) · Abbott Medical Optics (8) · Stanford University (8)
What is being tested here
Drugs under test in Astigmatism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Hyaluronic Acid | 1 | 0 | 1 |
| Propylene Glycol | 1 | 0 | 1 |
| Riboflavin | 0 | 0 | 1 |
| Dextrans | 0 | 0 | 1 |
| Proxymetacaine | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026P1 Toric Vs. Max 1day · Southern College of Optometry
- Dec 2026Evaluation of Orthokeratology Lenses With a 5MM Optic Zone Diameter · CooperVision International Limited (CVIL)
- Dec 2026A Planned Study at Multiple Sites is Being Done to Compare the Results of Two Types of Trifocal Toric Intraocular Lenses Used in Cataract Surgery · Biotech Healthcare Holding Gmbh
- Dec 2026A Clinical Trial Assessing the Safety and Effectiveness of Orthokeratology Lenses in Patients With Myopia and Myopic Astigmatism · Menicon Co., Ltd.
- Dec 2026Wear Experience With Daily Disposable Contact Lenses for Astigmatism Over a Long-Wear Day · Ohio State University
- Dec 2026Nomogram for Astigmatism Correction of KLEx · Tianjin Eye Hospital
- Jan 2027Improving Visual Quality in Patients With Irregular Corneas Using Asymmetrical Toric Intraocular Lenses · Johannes Kepler University of Linz
- Jan 2027Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens Surgery · Center For Sight
- Feb 2027Spectacle Prescribing in Early Childhood · University of Arizona
- Feb 2027Clinical Performance and Outcomes After Toric Lens Transition · CooperVision International Limited (CVIL)
Who these studies take
Of the 32 Astigmatism studies recruiting now, 12 (38%) set no upper age limit and 15 (47%) stop at 75 or younger. 5 (16%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 10 (31%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (13%) | 4 (13%) |
| 18 | 16 (50%) | 16 (50%) |
| 30 | 27 (84%) | 27 (84%) |
| 40 | 26 (81%) | 26 (81%) |
| 50 | 23 (72%) | 23 (72%) |
| 65 | 18 (56%) | 18 (56%) |
| 75 | 17 (53%) | 17 (53%) |
| 85 | 15 (47%) | 15 (47%) |
Across all 417 studies, recruiting or not: 36% stop at 75 or younger and 33% at 65; 12% take children; 0% are for women only and 0% for men only; 35% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Astigmatism studies take
Of 183 interventional studies with no phase under Astigmatism, half reached primary completion within 12 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 12 mo4–26 · 183 studies | 7 mo2–19 · 106 studies | 18 mo11–48 · 77 studies |
| Observational | 21 mo8–92 · 35 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting2
- Evaluation of Two Monthly Silicone Hydrogel Multifocal Toric in Soft Contact Lens WearersNov 4, 2026NCT07829419
- Evaluation of Orthokeratology Lenses With a 5MM Optic Zone DiameterOct 22, 2026NCT07751172
Stopped1
- Revive Toric RWE StudyWithdrawnOct 16, 2026NCT06785194
Newly registered3
- P1 Toric Vs. Max 1dayNov 4, 2026NCT07914959
- The EYERISING StudyNov 2, 2026NCT07909720
- Clinical Performance and Outcomes After Toric Lens TransitionOct 27, 2026NCT07898995
Studies
Recruiting first, then most recently updated. Showing 50 of 417. Browse all 417 → or search them.
- Clinical Performance and Outcomes After Toric Lens TransitionNot yet recruitingNCT07898995Not applicable1 country
- The EYERISING StudyNot yet recruitingNCT07909720Not applicable2 countries
- Evaluation of Two Monthly Silicone Hydrogel Multifocal Toric in Soft Contact Lens WearersRecruitingNCT07829419Not applicable1 country
- Clareon TruPlus StudyRecruitingNCT07502456Not applicable1 country
- Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens SurgeryRecruitingNCT07140653Phase 41 country
- Evaluation of Orthokeratology Lenses With a 5MM Optic Zone DiameterRecruitingNCT07751172Not applicable2 countries
- Wear Experience With Daily Disposable Contact Lenses for Astigmatism Over a Long-Wear DayRecruitingNCT07303920Not applicable1 country
- Effect of a Myopia Control Lens on the Astigmatism in ChildrenNot yet recruitingNCT07810725Not applicable
- Study of a Phakic Implantable Collamer Lens (ICL)Not yet recruitingNCT07790965Not applicable
- Evaluation of Mesopic Visual Acuity and Patient Satisfaction Following Ray-Tracing-Guided LASIKRecruitingNCT07790185Phase 41 country
- Study of an Implantable Collamer Lens (ICL)Not yet recruitingNCT07791381Not applicable
- SMILE Surgery in One Eye Compared to Ray Tracing-guided LASIK Surgery in the Fellow EyeRecruitingNCT07721714Phase 41 country
- Accuracy of Corneal Astigmatism in Different Region ModesRecruitingNCT032995301 country
- Corneal Biomechanics and Surgically Induced Astigmatism in Pseudoexfoliation SyndromeRecruitingNCT077222471 country
- Effect of WRAD Lens on Axial Growth and Refraction in Low-hyperopic Chinese ChildrenNot yet recruitingNCT07682974Not applicable
- Effect of Dry Eye Treatment on Corneal Astigmatism MeasurementsRecruitingNCT07657858Not applicable1 country
- Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive ErrorsNot yet recruitingNCT076471461 country
- Nomogram for Astigmatism Correction of KLExRecruitingNCT07605221Not applicable1 country
- Optimizing the Ocular Surface With Systane COMPLETE Pre- and Post-operatively in Patients With Dry Eye Planning for Cataract Surgery: An Extension Study of Optimizing the Ocular Surface With Systane COMPLETE in Patients With Dry Eye Planning for Cataract SurgeryRecruitingNCT06886373Phase 41 country
- Postoperative Rotational Dynamics of Three Toric Intraocular Lens DesignsRecruitingNCT07453992Not applicable1 country
- A Study to Investigate the Safety and Effectiveness of the Technolas® TENEO 317 Model 2 Excimer Laser for Laser In Situ Keratomileusis (LASIK) Surgery to Treat Myopia or Myopic AstigmatismNot yet recruitingNCT07377474Not applicable
- Improving Visual Quality in Patients With Irregular Corneas Using Asymmetrical Toric Intraocular LensesRecruitingNCT07294716Not applicable1 country
- Wavefront-guided LASIK Surgery Compared to Ray Tracing-Guided LASIK SurgeryRecruitingNCT07078799Not applicable1 country
- Assessing the Turkish DDIVAT for Visual Acuity MeasurementNot yet recruitingNCT07240480
- A Planned Study at Multiple Sites is Being Done to Compare the Results of Two Types of Trifocal Toric Intraocular Lenses Used in Cataract SurgeryRecruitingNCT07232615Not applicable3 countries
- Clinical Evaluation of WaveLight Plus LASIKRecruitingNCT071277571 country
- A Three-Phase Contralateral Comparison of Ray-Tracing Guided LASIK Versus Three Other Refractive Surgery Platforms to Correct Myopia or Myopia With AstigmatismRecruitingNCT07201298Not applicable1 country
- Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft TransplantationEnrolling by invitationNCT07198126Not applicable1 country
- Performance of Large Language Models for Structured Recognition and Refractive PredictionRecruitingNCT071838911 country
- Effectiveness, Stability and Influence Factors of Femtosecond Laser Assisted Cataract SurgeryRecruitingNCT070819191 country
- A Clinical Trial Assessing the Safety and Effectiveness of Orthokeratology Lenses in Patients With Myopia and Myopic AstigmatismNot yet recruitingNCT07047924Not applicable1 country
- Algorithm-assisted Subjective Refraction Program Dedicated to ChildrenRecruitingNCT07046065Not applicable1 country
- Observational Study - TA- 2025-1Enrolling by invitationNCT070078971 country
- Rotation of Hydrophobic Acrylic Lenses - Rayner RA0800C & Alcon Clareon & Hoya Nanex & Hoya Vivinex XY1-EM & RayOne EMV Toric & PODEYE ToricRecruitingNCT03803852Not applicable1 country
- The Objective of This Study is to Evaluate the Perfomance of a Photorefraction Device for Screening Ametropia in Children. Eligible Participants Will Undergo Multiple Refractive Error Measurements, Visual Acuity and Strabismus Assessments During a Single Evaluation Visit.RecruitingNCT06882408Not applicable1 country
- Effectiveness and Safety of Limbal Relaxing Incisions for Correcting Post Phacoemulsification High AstigmatismNot yet recruitingNCT06896357Phase 1
- Correlation Between Preoperative Refraction and Anterior Segment Parameters With ICL VaultEnrolling by invitationNCT05670626Not applicable1 country
- A Prospective, Randomized Clinical Study of Two Phakic Toric Implantable LensesRecruitingNCT06839898Not applicable2 countries
- Application of Phototherapeutic Keratectomy Mode to Mark the Axis of AstigmatismRecruitingNCT06694051Not applicable1 country
- An Evaluation of LASIK, SMILE and PRK Surgery in PhysiciansRecruitingNCT025764831 country
- A Prospective Clinical Investigation to Evaluate the Safety and Performance of 877PTY Toric IOL for Visual Correction of Corneal AstigmatismEnrolling by invitationNCT065788841 country
- Comparative Functional Vision Outcomes: DAILIES TOTAL1 Toric vs. Spherical Lenses in Asian Astigmatic PatientsRecruitingNCT06230263Not applicable1 country
- A Study of Artificial Intelligence Assisted Small Incision Lenticule Extraction (SMILE) for Surgical Design and Influencing FactorsRecruitingNCT062293011 country
- Femtosecond Laser Arcuate Keratotomy Versus Toric Intraocular Lens Implantation in Cataract SurgeryRecruitingNCT06215807Not applicable1 country
- Total Corneal Astigmatism Prevalence in Cataract PatientsNot yet recruitingNCT061488571 country
- Using the VisuMax Femtosecond Laser System to Perform SMILE Optimized for Presbyopia by Modulation of Postoperative Spherical AberrationEnrolling by invitationNCT05684237Not applicable1 country
- Evaluation of Different Lenticule Diameters in Myopic Astigmatism Correction With SMILE ProceduresRecruitingNCT06062004Not applicable1 country
- Software Refraction With Mobilerone Versus RetinoscopyRecruitingNCT06059521Not applicable1 country
- EyeQue VisionCheck 510(k) Clinical TrialNot yet recruitingNCT06044688Not applicable
- Dresden Corneal Disease and Treatment StudyRecruitingNCT042511431 country