An interventional study of Pterygium Excision with Conjunctival Autograft in Pterygium and Corneal Astigmatism, sponsored by Mughal Eye Trust Hospital. Enrolling by invitation at 1 site in Pakistan. Open to participants aged 30 Years to 70 Years. Per ClinicalTrials.gov, last updated 2025-09-30.
Sponsored by Mughal Eye Trust Hospital · Not applicable, Interventional, and Treatment
Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted vision (astigmatism). The condition is more frequent in people exposed to sunlight, dust, and dry environments.
The standard treatment for symptomatic pterygium is surgical removal. However, simple removal has a high chance of recurrence. To reduce this risk, surgeons commonly use a technique called conjunctival autograft transplantation, where a small piece of the patient's own conjunctiva is placed over the area after excision. This method not only lowers the recurrence rate but may also improve vision by reducing corneal irregularities.
This study is designed to measure the changes in corneal curvature (keratometric readings) before and after pterygium excision with conjunctival autograft transplantation. By comparing preoperative and postoperative measurements, the study aims to determine how much this surgery improves corneal shape and reduces astigmatism.
The hypothesis is that pterygium excision with conjunctival autograft transplantation will lead to a significant improvement in keratometric readings and reduce irregular astigmatism, thereby improving visual quality.
This research will provide local evidence of the effectiveness of this procedure and help guide treatment strategies for patients suffering from pterygium-related visual problems.
109 studies on the registry are indexed under Pterygium; 9 are open to participants now.
This study's planned enrollment of 130 is above the median of 60 across 93 interventional studies indexed under Pterygium.
Browse Pterygium studies →Mughal Eye Trust Hospital is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients will undergo surgical excision of pterygium followed by conjunctival autograft transplantation. The autograft will be harvested from the superior bulbar conjunctiva and secured at the excision site using sutures.
Procedure: Pterygium Excision with Conjunctival Autograft
Excision of primary Grade II or Grade III pterygium Conjunctival autograft harvested and transplanted at the excision site Graft secured with sutures
Change in Keratometric Readings (K1 and K2)
Keratometric readings, including the flat meridian (K1) and steep meridian (K2) of the anterior corneal surface, will be measured using a manual keratometer. The mean change in K-readings (measured in diopters) from baseline (pre-operative) to post-operative assessment will be calculated to evaluate corneal curvature improvement following pterygium excision with conjunctival autograft.
Time frame: Baseline (pre-operative) and 1 month post-operative.
Change in Astigmatism
Astigmatism will be measured using an automated refractometer. Both type (regular/irregular, with-the-rule/against-the-rule) and degree of astigmatism (in diopters) will be recorded. The reduction in astigmatism from baseline to post-operative follow-up will be assessed.
Time frame: Baseline (pre-operative) and 1 month post-operative.
Started Aug 2025 (actual). Primary completion is estimated for Feb 2026, 5 months after the start.
Of 18 interventional studies with no phase under Pterygium, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 28. This study's planned 5 months is below that.
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Mughal Eye Trust Hospital