An observational study in Myopia, Hyperopia and Astigmatism, sponsored by Sohag University. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years to 99 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-15.
Sponsored by Sohag University · Observational
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.
Refractive errors are among the most common ocular conditions affecting visual acuity. Corneal epithelial thickness has been suggested to play a role in the optical properties of the eye and may vary among different refractive states. This observational study aims to evaluate corneal epithelial thickness mapping using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. Patients will be assessed and categorized according to their refractive status, and epithelial thickness measurements will be obtained and analyzed. The study seeks to investigate potential correlations between epithelial thickness distribution and different types of refractive errors to enhance understanding of corneal biomechanics in refractive conditions.
1,159 studies on the registry are indexed under Myopia; 225 are open to participants now.
This study's planned enrollment of 360 is above the median of 150 across 204 observational studies indexed under Myopia.
Browse Myopia studies →Sohag University is the lead sponsor of 1,230 studies on the registry; 636 are open to participants now.
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Adult participants (≥18 years) with refractive errors, including myopia, hyperopia, and astigmatism, as well as emmetropic subjects, recruited from the Ophthalmology Department and undergoing anterior segment optical coherence tomography (AS-OCT) examination.
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Exclusion Criteria:
All participants diagnosed with refractive errors (myopia, hyperopia, astigmatism) and emmetropia will be included in the study. All subjects will undergo anterior segment optical coherence tomography (AS-OCT) for corneal epithelial thickness mapping. Participants will then be analyzed according to their refractive status.
Measurement of corneal epithelial thickness using AS-OCT
Corneal epithelial thickness will be measured using anterior segment optical coherence tomography (AS-OCT). Measurements will include central and regional epithelial thickness values in microns in patients with different refractive errors.
Time frame: At baseline during a single study visit when participants undergo AS-OCT examination.
Comparison of epithelial thickness between myopic and hyperopic eyes
Corneal epithelial thickness will be compared between myopic and hyperopic eyes using AS-OCT measurements.
Time frame: At baseline (single visit)
Comparison of epithelial thickness in eyes with and without astigmatism
Corneal epithelial thickness will be evaluated and compared between eyes with astigmatism and those without astigmatism using AS-OCT.
Time frame: At baseline (single visit)
Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison
Epithelial thickness will be assessed across different corneal regions and compared between both eyes to evaluate inter-eye asymmetry.
Time frame: At baseline (single visit)
Comparison of epithelial thickness in low and high refractive errors
Corneal epithelial thickness profiles will be compared between low and high degrees of myopia and hyperopia using AS-OCT measurements.
Time frame: At baseline (single visit)
Plan to share: No — Individual participant data will not be shared.
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This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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