Aortic Valve Insufficiency clinical trials

The registry lists 169 studies for Aortic Valve Insufficiency across more than 10 countries. 54 are recruiting or about to start. 71 of them are mainly about Aortic Valve Insufficiency (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.

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Status

Completed: 62
Recruiting: 39
Status unknown: 22
Active, not recruiting: 16
Terminated: 12
Not yet recruiting: 11

Phase

Phase 4: 7
Phase 3: 3
Phase 1: 2
Phase 2: 2

Where

United States: 41
Germany: 24
China: 21
Italy: 20
Canada: 15
France: 15

Who runs them

Abbott Medical Devices (8) · Edwards Lifesciences (7) · JenaValve Technology, Inc. (6) · The Cleveland Clinic (5) · Biostable Science & Engineering (4) · JC Medical, Inc., an affiliate of Edwards Lifesciences LLC (3) · Suzhou Hearthill Medical Technology Co.,LTD (3) · Assistance Publique - Hôpitaux de Paris (3)

What is being tested here

Drugs under test in Aortic Valve Insufficiency studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Losartan	1	0	1
Propofol	0	1	3
Isoflurane	0	1	3
Sevoflurane	0	1	3
Warfarin	0	0	1
Metoprolol	0	0	1
Sacubitril valsartan	0	0	1
Rivaroxaban	0	0	1
Aspirin	0	0	1
Antithrombin III	0	0	1

Drug classes tested here Inhaled anesthetics 3

Coming up

0phase 3 studies under way

14studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Dec 2026Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes · University Hospital, Lille
Dec 2026A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease · McGill University Health Centre/Research Institute of the McGill University Health Centre
Dec 2026TAVR for Aortic Regurgitation Under TTE Guidance · Chinese Academy of Medical Sciences, Fuwai Hospital
Dec 2026TAVR for Aortic Regurgitation Under TEE Guidance · Chinese Academy of Medical Sciences, Fuwai Hospital
Dec 2026Early Aortic vaLve surgEry Versus wAtchful waitiNg Strategy in Severe Asymptomatic aOrtic reguRgitation · Na Homolce Hospital
Jan 2027Evaluation of Safety and Effectiveness of the EMBLOK EPS Compared With No Cerebral Embolic Protection During TAVR · Emblok, Inc.
Mar 2027Impact of Anesthesia, Positive Pressure Ventilation and Modality of Imaging on the Echocardiographic Assessment of the Severity of Aortic Regurgitation · University of Liege
Jun 2027ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™ · JenaValve Technology, Inc.
Jun 2027Towards a More Standardized Bicuspid Aortic Valve Repair: Rationale and Design of CONTOUR Trial - a Randomized Trial · University Hospital Augsburg
Jun 2027Identification of Genetic Causes of Calcific Aortic Valve Disease · Beth Israel Deaconess Medical Center

Who these studies take

Of the 39 Aortic Valve Insufficiency studies recruiting now, 31 (79%) set no upper age limit and 2 (5%) stop at 75 or younger. 4 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (10%) take healthy volunteers.

Recruiting studies that take each age, of 39
Age	Women	Men
10	3 (8%)	3 (8%)
18	30 (77%)	30 (77%)
30	32 (82%)	32 (82%)
40	32 (82%)	32 (82%)
50	34 (87%)	34 (87%)
65	36 (92%)	36 (92%)
75	37 (95%)	37 (95%)
85	35 (90%)	35 (90%)

Across all 169 studies, recruiting or not: 7% stop at 75 or younger and 5% at 65; 14% take children; 1% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Aortic Valve Insufficiency studies take

Of 44 interventional studies with no phase under Aortic Valve Insufficiency, half reached primary completion within 57 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	57 mo26–74 · 44 studies	—	—
Observational	86 mo37–132 · 34 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Started recruiting2

Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world PracticeOct 30, 2026NCT07068633
SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY TrialOct 30, 2026NCT07872020

Newly registered1

SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY TrialOct 13, 2026NCT07872020

Studies

Recruiting first, then most recently updated. Showing 50 of 169. Browse all 169 → or search them.