An observational study in Aortic Valve Regurgitation, Mitral Valve Regurgitation and Left Ventricle Dilated, sponsored by Petrovsky National Research Centre of Surgery. Recruiting at 2 sites in Russian Federation. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-11.
Sponsored by Petrovsky National Research Centre of Surgery · Observational
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.
169 studies on the registry are indexed under Aortic Valve Insufficiency; 54 are open to participants now.
This study's planned enrollment of 120 is below the median of 224 across 74 observational studies indexed under Aortic Valve Insufficiency.
Browse Aortic Valve Insufficiency studies →Petrovsky National Research Centre of Surgery is the lead sponsor of 18 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who underwent open surgical correction of aortic insufficiency with the background of severe eccentric remodeling of the left ventricle (EDV more than 250 ml). Men and women over 18 years of age.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with functional mitral regurgitation grade 0-1, 1 and 1-2 without mitral valve repair (MvR)
Other: Not applicable - observational study
Patients with mitral valve functional regurgitation of grade 2 and more severe without mitral valve repair
Other: Not applicable - observational study
Patients with functional mitral regurgitation grade 0-1, 1 and 1-2, mitral valve repaired
Other: Not applicable - observational study
Patients with mitral valve functional regurgitation of grade 2 and more severe, mitral valve repaired
Other: Not applicable - observational study
observation only
Also known as: observation
LV end-diastolic volume (EDV) decrease
Change in end-diastolic volume of the left ventricle, assessed with EchoCG after surgical correction of aortic insufficiency
Time frame: 3 and 12 months after surgery
Freedom from readmission
Freedom from readmission due to valvular problem or heart failure-related reason
Time frame: 12 months after surgery
Life quality
The patient's life quality according to the results of the EuroQol-5D-5L (EQ-5D-5L) questionnaire (0-100 points, the higher - the better).
Time frame: Upon inclusion, 10 days post-surgery, 3 month and 12 month post-surgery
LV ejection fraction (EF)
Left ventricle ejection fraction, assessed with EchoCG
Time frame: 3 and 12 month post-surgery
LV diastolic function
Left ventricle diastolic function, assessed with EchoCG
Time frame: Upon inclusion, 3 month and 12 month post-surgery
Left atrium volume index (LAVI)
Left atrium volume indexed to body surface area, assessed with EchoCG
Time frame: Upon inclusion, 3 month and 12 month post-surgery
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Petrovsky National Research Centre of Surgery