Aortic Valve Disease clinical trials

The registry lists 234 studies for Aortic Valve Disease across more than 10 countries. 70 are recruiting or about to start. 139 of them are mainly about Aortic Valve Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 6 narrower conditions too, such as Aortic Valve Stenosis: 1,692 studies, 498 open.

Get an email when these change. Save the Aortic Valve Disease studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.

Watch these studies

See an example email

Example · made-up studies

Breast cancer · Recruiting: 2 came in, 3 changed

What changed in your saved searches, Oct 31 – Nov 6:

A study of drug A after surgery for early breast cancer

Came in · now Recruiting

Drug B with hormone therapy in advanced breast cancer

Changed

· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

Exercise during chemotherapy

Now Active, not recruiting

One email a week for all your saved searches. Stop any time.

Status

Completed: 89
Recruiting: 46
Active, not recruiting: 26
Status unknown: 26
Not yet recruiting: 19
Terminated: 19

Phase

Phase 4: 12
Phase 2: 8
Phase 3: 5

Where

United States: 47
Germany: 44
China: 26
France: 26
Italy: 24
Netherlands: 23

Who runs them

Edwards Lifesciences (13) · Abbott Medical Devices (8) · Corcym S.r.l (7) · JenaValve Technology, Inc. (5) · Medical University of Vienna (4) · Assiut University (4) · Rigshospitalet, Denmark (3) · Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec (3)

What is being tested here

Drugs under test in Aortic Valve Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Rivaroxaban	1	0	3
Apixaban	1	2	3
Vericiguat	1	0	1
Dexamethasone phosphate	1	0	1
Dexamethasone	1	0	1
Olanzapine	1	0	1
Clopidogrel	0	0	4
Warfarin	0	0	3
Aspirin	0	0	3
Colchicine	0	1	1

Drug classes tested here Factor Xa inhibitors 2 open

Coming up

2phase 3 studies under way

21studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Dec 2026Colchicine and Inflammation in Aortic Stenosis · Phase 3 · Radboud University Medical Center
Nov 2026Avalus Ultra Post-Approval Study (PAS) · Medtronic Cardiac Surgery
Dec 2026Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR · EnCompass Technologies, Inc.
Dec 2026Real World Data Collection on the INSPIRIS RESILIA Aortic Valve · Edwards Lifesciences
Dec 2026COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction · Edwards Lifesciences
Dec 2026Evaluation of the Viability and Safety of Early Discharge Protocol After TAVI Implantation · Fundación EPIC
Dec 2026Prospective Long-Term Outcomes of a Standardized Ross Procedure · Baylor Research Institute
Dec 2026Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation · Nanjing First Hospital, Nanjing Medical University
Dec 2026Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients · University of Turku
Dec 2026Soft Foam Dressings for Pressure Injury Prevention of Cardiac Surgery · Shih,Wen-Chi

Who these studies take

Of the 46 Aortic Valve Disease studies recruiting now, 34 (74%) set no upper age limit and 5 (11%) stop at 75 or younger. 4 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (7%) take healthy volunteers.

Recruiting studies that take each age, of 46
Age	Women	Men
10	4 (9%)	4 (9%)
18	34 (74%)	34 (74%)
30	37 (80%)	37 (80%)
40	38 (83%)	38 (83%)
50	41 (89%)	41 (89%)
65	45 (98%)	45 (98%)
75	42 (91%)	42 (91%)
85	38 (83%)	38 (83%)

Across all 234 studies, recruiting or not: 7% stop at 75 or younger and 3% at 65; 12% take children; 0% are for women only and 0% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Aortic Valve Disease studies take

Of 61 interventional studies with no phase under Aortic Valve Disease, half reached primary completion within 41 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	41 mo20–61 · 61 studies	—	—
Observational	49 mo23–97 · 56 studies	—	49 mo23–147 · 47 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Newly registered1

Long-Term Performance of Kingstron X-LINK Compared With Commercial BioprosthesesNov 6, 2026NCT07921797

Studies

Recruiting first, then most recently updated. Showing 50 of 234. Browse all 234 → or search them.