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Status unknownNCT05036031TEA-ACLFUpdated Sep 5, 2021

Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study

An observational study in Acute-On-Chronic Liver Failure, Liver Cirrhosis and Liver Transplant; Complications, sponsored by RenJi Hospital. Status unknown. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-09-05.

Sponsored by RenJi Hospital · Observational

The sponsor has not verified this record recently (last verified Sep 2021), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
500
Ages
18 Years to 80 Years
Sex
All
01

Study summary

The definition and diagnostic criteria of acute-on chronic liver failure (ACLF) differed evidently between the East and the West due to the difference in the underlying etiology. Liver transplantation is the most effective treatment to reverse the progress of ACLF and improve the survival rate of patients. The purpose of this study is to explore the accuracy of the two diagnostic criteria of EASL-CLIF and APASL ACLF in assessing the survival rate of patients with liver cirrhosis after LT.

Read the detailed description

A retrospective collection and analysis of the preoperative conditions of patients with LT due to cirrhosis in a single center from January 2015 to June 2020 would be conducted, including epidemiological characteristics, etiology, clinical indicators, and short-term (28 days, 90 days) and long-term (1 year, 3 years) survival after LT.

02

Conditions studied

  • Acute-On-Chronic Liver Failure
  • Liver Cirrhosis
  • Liver Transplant; Complications

Keywords

  • Acute-On-Chronic Liver Failure
  • EASL-CLIF criteria
  • APASL criteria
03

In context

Liver Cirrhosis

1,642 studies on the registry are indexed under Liver Cirrhosis; 358 are open to participants now.

This study's planned enrollment of 500 is above the median of 151 across 587 observational studies indexed under Liver Cirrhosis.

Browse Liver Cirrhosis studies →

Lead sponsor

RenJi Hospital is the lead sponsor of 535 studies on the registry; 244 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

patients underwent liver transplantation for cirrhosis at Renji Hospital, School of Medicine, Shanghai Jiao Tong University, China between January 2015 and June 2020 were considered for inclusion.

Inclusion criteria

  • patients underwent liver transplantation for cirrhosis
  • The diagnosis of ACLF followed APASL and EASL-CLIF definition.

Exclusion criteria

Exclusion Criteria:

  • Patients with malignant tumor or underwent living donor liver transplantation (LDLT) were excluded.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
500 participants (estimated)
Patient registry
No

Groups and cohorts

  • EASL-CLIF ACLF patients
  • APASL ACLF patients
  • Non-ACLF patients
06

What researchers measure

Primary outcomes

  1. 3 years overall survival

    Time frame: Up to ~3 years

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 5, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05036031
Lead sponsor
RenJi Hospital
Responsible party
Sponsor
First posted
Sep 5, 2021
Start date
Sep 1, 2021 (estimated)
Primary completion
Oct 1, 2021 (estimated)
Completion
Oct 31, 2021 (estimated)
Last update
Sep 5, 2021

Study contacts

Hao Feng, MD., Ph.D.
Contact
surgeonfeng@live.com
008615000901110
Qiang Xia
study chair · Dept. Liver Surgery, Renji Hospital, School of Medicine, SJTU
Hao Feng
principal investigator · Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.

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